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hodnotící studie

Works consisting of studies determining the effectiveness or utility of processes, personnel, and equipment.
MSH

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sacharosa

A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.
MSH

nonreducing disaccharide, composed of glucose and fructose linked via their anomeric carbons.
CSP

A disaccharide consisting of glucose and fructose. The linkage is alpha with respect to the glucose and beta with respect to the fructose.
NCI

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fykokyanin

The metal-free blue phycobilin pigment in a conjugated chromoprotein of blue-green algae. It functions as light-absorbing substance together with chlorophylls.
MSH

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glucarpidase

A bacterial enzyme that breaks down proteins and other substances, including methotrexate. It is being studied in the treatment of toxic effects caused by methotrexate. It may also help activate certain drugs to kill cancer cells. It is a type of chemoprotective agent and a type of prodrug activator.
NCI

A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.
NCI

A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because carboxypeptidase-G2 rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for carboxypeptidase-G2-catalyzed activation of a co-administered prodrug at the site of the tumor. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41665&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41665&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C346″ NCI Thesaurus)
PDQ

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Kentucky

A state in the north central United States. Its capital is Frankfort.
NCI

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exotropie

A form of ocular misalignment where the visual axes diverge inappropriately. For example, medial rectus muscle weakness may produce this condition as the affected eye will deviate laterally upon attempted forward gaze. An exotropia occurs due to the relatively unopposed force exerted on the eye by the lateral rectus muscle, which pulls the eye in an outward direction.
MSH

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sulfátadenylyltransferasa

An enzyme that catalyzes the activation of sulfate ions by ATP to form adenosine-5`-phosphosulfate and pyrophosphate. This reaction constitutes the first enzymatic step in sulfate utilization following the uptake of sulfate. EC 2.7.7.4.
MSH

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physiopathological

Used with organs and diseases for disordered function in disease states.
MSH

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karcinom skirhotický

An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)
MSH

An infiltrating adenocarcinoma characterized by the presence of desmoplastic stromal reaction.
NCI

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kyseliny ketoglutarové

A family of compounds containing an oxo group with the general structure of 1,5-pentanedioic acid. (From Lehninger, Principles of Biochemistry, 1982, p442)
MSH

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oční banky

Centers for storing various parts of the eye for future use.
MSH

An eye bank procures and distributes eyes for transplant, education and research. To promote patient safety, donated eyes and donor medial histories are evaluated based on strict Eye Bank Association of America Medical Standards


HL7V3.0

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estery kyseliny sírové

Organic esters of sulfuric acid.
MSH

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pilotní projekty

Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
MSH

The initial study examining a new method or treatment.
NCI

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karfecilin

The phenyl ester of CARBENICILLIN that, upon oral administration, is broken down in the intestinal mucosa to the active antibacterial. It is used for urinary tract infections.
MSH

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polycystické ledviny – nemoci

hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed cysts within the kidney; there is an autosomal recessive form appearing in childhood and a later appearing autosomal dominant form; a similar acquired disease sometimes accompanies end-stage renal disease.
CSP

A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.
NCI

Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.
MSH

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nervus facialis

The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and salivary glands, and convey afferent information for taste from the anterior two-thirds of the tongue and for touch from the external ear.
MSH

seventh cranial nerve; has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root, which together provide efferent innervation to the muscles of facial expression and to the lacrimal and salivary glands, and convey afferent information for taste from the anterior two-thirds of the tongue and for touch from the external ear.
CSP

The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and salivary glands, and convey afferent information for taste from the anterior two-thirds of the tongue and for touch from the external ear. (MeSH)
NCI

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supratentoriální nádory

Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.
MSH

A benign or malignant neoplasm that occurs within the intracranial cavity above the tentorium cerebelli.
NCI

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hypofýza – přední lalok

The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.
MSH

The glandular or anterior lobe of the pituitary gland which secretes several hormones.
NCI

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chrupavka

A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
MSH

nonvascular form of connective tissue composed of chondrocytes embedded in a matrix of type II collagen and chondroitin sulfate; divided into three types: hyaline cartilage, fibrocartilage, and yellow or elastic white fibrocartilage.
CSP

A tough, flexible tissue that lines joints and gives structure to the nose, ears, larynx, and other parts of the body.
NCI

Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage.
FMA

A type of connective tissue composed of chondrocytes and an extracellular matrix, composed of collagen, elastin, and ground substance. There are three types of cartilage; namely elastic, hyaline, and fibrocartilage.
NCI

A tough, elastic, fibrous connective tissue found in various parts of the body, such as the joints, outer ear, and larynx.
CHV

Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage.
UWDA

A type of connective tissue composed of chondrocytes and an extracellular matrix, composed of collagen, elastin, and ground substance. There are three types of cartilage; namely elastic, hyaline, and fibrocartilage.
NCI

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znalostní báze

A database or other collection of knowledge expressed in a formal knowledge representation language.
NCI

Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
MSH

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fakulta

The teaching staff and members of the administrative staff having academic rank in an educational institution.
MSH

The body of teachers and administrators at a school.
NCI

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chirurgické nástroje

Hand-held tools or implements used by health professionals for the performance of surgical tasks.
MSH

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plankton

Community of tiny aquatic PLANTS and ANIMALS, and photosynthetic BACTERIA, that are either free-floating or suspended in the water, with little or no power of locomotion. They are divided into PHYTOPLANKTON and ZOOPLANKTON.
MSH

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sumci

Common name of the order Siluriformes. This order contains many families and over 2,000 species, including venomous species. Heteropneustes and Plotosus genera have dangerous stings and are aggressive. Most species are passive stingers.
MSH

snout contains 1-4 pairs barbels, small eyes, flattened head, adipose fin; streamlined body shape, either without scales or is covered by heavy, bony plates.
CSP

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porodní doba druhá

The period of OBSTETRIC LABOR that is from the complete dilatation of the CERVIX UTERI to the expulsion of the FETUS.
MSH

A stage during labor and childbirth when the cervix is effaced totally and remains dilated until the birth of the baby.
NCI

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Fasciola

A genus of trematode liver flukes of the family Fasciolidae. Two species of this genus are F. hepatica and F. gigantica. The parasites are found in the liver and gallbladder and associated ducts in mammals and occasionally man. F. gigantica occurs rarely in man.
MSH

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prasata – nemoci

Diseases of domestic swine and of the wild boar of the genus Sus.
MSH

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Plasmodium berghei

protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.
CSP

A protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.
MSH

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proteinkinasa CDC28, S cerevisiae

A protein kinase encoded by the Saccharomyces cerevisiae CDC28 gene and required for progression from the G1 PHASE to the S PHASE in the CELL CYCLE.
MSH

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laktoferrin

An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the type III secretion system used by bacteria to export virulence proteins for host cell invasion.
MSH

iron binding protein found in the specific granules of neutrophils where it exerts an antimicrobial activity by withholding iron from ingested bacteria and fungi; occurs in many excretions and exudates.
CSP

Lactotransferrin (710 aa, ~78 kDa) is encoded by the human LTF gene. This protein is involved in the mediation of both proteolysis and iron transport.
NCI

A protein that is found in milk, tears, mucus, bile, and some white blood cells and is being studied in the treatment and prevention of cancer. It is involved in fighting against infection and inflammation and it acts as an antioxidant.
NCI

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