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dermotoxiny

Specific substances elaborated by plants, microorganisms or animals that cause damage to the skin; they may be proteins or other specific factors or substances; constituents of spider, jellyfish or other venoms cause dermonecrosis and certain bacteria synthesize dermolytic agents.
MSH

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kyselina 4-aminobenzoová

A member of the VITAMIN B COMPLEX. It used to be common in SUNSCREENING AGENTS until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.
MSH

An organic acid with UV absorption and antifibrotic properties. When exposed to light, aminobenzoic acid (para-aminobenzoic acid or PABA) absorbs UV light and emits excess energy via a photochemical reaction that may cause damage to DNA. Because DNA defects contribute to skin cancer, aminobenzoic acid is no longer widely used in sunscreen formulations. Aminobenzoic acid may also increase oxygen uptake at the tissue level and may enhance monoamine oxidase (MAO) activity to promote the degradation of serotonin, which in excess, may lead to fibrotic changes.
NCI

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Bacteria that live in the intestines need para-aminobenzoic acid to survive. Para-aminobenzoic acid is found in grains and foods from animals. It is being studied as a radiosensitizer (a substance that makes tumor cells more sensitive to radiation therapy) and in the treatment of certain skin disorders.
NCI

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Bacteria that live in the intestines need aminobenzoic acid to survive. Aminobenzoic acid is found in grains and foods from animals. It is being studied as a radiosensitizer (a substance that makes tumor cells more sensitive to radiation therapy) and in the treatment of certain skin disorders.
NCI

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autonomní vlákna postgangliová

nerve fibers which project from cell bodies of autonomic ganglia to synapses on target organs.
CSP

Nerve fibers which project from cell bodies of autonomic ganglia to synapses on target organs. (MeSH)
NCI

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proestrus

A phase of the ESTROUS CYCLE that precedes ESTRUS. During proestrus, the Graafian follicles undergo maturation.
MSH

The estrous cycle phase in which there is heightened follicular activity. [GOC:dph, ISBN:0721662544 “Dorland`s Illustrated Medical Dictionary”]
GO

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Indri

Species in the genus Propithecus.
MSH

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dextroamfetamin

The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
MSH

d-form of amphetamine; it is a central nervous system stimulant and a sympathomimetic; it has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children; dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase; it is also a drug of abuse and a psychotomimetic.
CSP

A synthetic substance related to natural sympathomimetic amines and the synthetic agent amphetamine. In the central nervous system (CNS), dextroamphetamine induces the release of dopamine within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria. As a CNS stimulant, this agent may increase blood pressure and reduce appetite. Similar to other amphetamines, dextroamphetamine has a high potential for abuse, dependence, and addiction if used in large doses over extended periods of time. (NCI04)
NCI

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kalcimycin

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
MSH

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azakosterol

Diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase, which causes the accumulation of desmosterol.
MSH

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prolaps

The protrusion of an organ or part of an organ into a natural or artificial orifice.
MSH

abnormal lowering of an organ or a part
CHV

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Infekční otitis externa, blíže neurčená

A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer`s ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.
NCI

A bacterial infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer`s ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and pain in the ear and ear drainage.
NCI

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diagnóza stomatologická

Examination of the mouth and teeth toward the identification and diagnosis of intraoral disease or manifestation of non-oral conditions.
MSH

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potrat neúplný

Premature loss of PREGNANCY in which not all the products of CONCEPTION have been expelled.
MSH

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Babesia microti

A species of protozoa infecting humans via the intermediate tick vector IXODES scapularis. The other hosts are the mouse PEROMYSCUS leucopus and meadow vole MICROTUS pennsylvanicus, which are fed on by the tick. Other primates can be experimentally infected with Babesia microti.
MSH

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Propidium Iodide

A fluorescent nucleic acid dye which binds only to double-stranded nucleic acids. It has a molecular weight of 668.4, an absorbance maximum of 535nm, and an emission maximum of 617 nm. It is commonly used to determine the DNA content of a cell or to discriminate viable from non-viable cells.
NCI

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injekce intraarteriální

Injection, intraarterial


HL7V3.0

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diazepam

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
MSH

benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action; its actions are mediated by enhancement of amma-aminobutyric acid activity; it is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
CSP

antianxiety drug
CHV

A drug used to treat mild to moderate anxiety and tension and to relax muscles. It is a type of benzodiazepine.
NCI

A benzodiazepine derivative with anti-anxiety, sedative, hypnotic and anticonvulsant properties. Diazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic system and the hypothalamus. This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability.
NCI

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úrazy – dispozice

Tendency toward involvement in accidents. Implies certain personality characteristics which predispose to accidents.
MSH

tendency toward involvement in accidents; implies certain personality or other characteristics which predispose to accidents.
CSP

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bakteriolýza

rupture of bacterial cells due to mechanical force, chemical action, or the lytic growth of bacteriophages.
CSP

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prostaglandinové endoperoxidy syntetické

Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
MSH

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hmyzí hormony

Hormones secreted by insects. They influence their growth and development. Also synthetic substances that act like insect hormones.
MSH

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Dictyocaulus – infekce

Infection with nematodes of the genus DICTYOCAULUS. In deer, cattle, sheep, and horses the bronchi are the site of infestation.
MSH

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kyseliny octové

Acetic acid and its derivatives which may be formed by substitution reactions. Mono- and di-substituted, as well as halogenated compounds have been synthesized.
MSH

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síran barnatý

A compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield.
MSH

The sulfate salt of barium, an alkaline, divalent metal. Barium sulfate is quite insoluble in water, and is used as a radiopaque agent to diagnose gastrointestinal medical conditions. Barium sulfate is taken by mouth or given rectally. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=483042&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=483042&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28859″ NCI Thesaurus)
PDQ

The sulfate salt of barium, an alkaline, divalent metal. Barium sulfate is quite insoluble in water, and is used as a radiopaque agent to diagnose gastrointestinal medical conditions. Barium sulfate is taken by mouth or given rectally. (NCI04)
NCI

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ochranné látky

Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
MSH

A class of agents used in prophylactic or curative therapy to attenuate the negative side effects of toxins or drugs. Protective agents belong to various chemical classes, acting through various pharmacological mechanisms. They may neutralize exogenous poisons, coat mucosa for protection against physical or chemical damage, offer antioxidant protection against free radicals or ionizing radiation, or induce endogenous detoxifying enzymes. (NCI04)
NCI

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insulin – rezistence

Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
MSH

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diethylpyrokarbonát

Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.
MSH

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acetylprokainamid

A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
MSH

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Bayesova věta

A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihoods of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
MSH

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prothionamid

Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.
MSH

A thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH-NAD, which competitively inhibits 2-trans-enoyl-ACP reductase (inhA), an enzyme essential for mycolic acid synthesis. This results in increased cell wall permeability and decreased resistance against cell injury eventually leading to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.
NCI

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inteligenční testy

Standardized tests that measure the present general ability or aptitude for intellectual performance.
MSH

standardized tests which measure a wide range of abilities, including verbal, numerical and social competence; includes Stanford-Binet test, Wechsler-Bellevue scale and Wechsler Intelligence scale.
CSP

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