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pilotní projekty

Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
MSH

The initial study examining a new method or treatment.
NCI

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tvrdost – testy

A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
MSH

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dihydroalprenolol

Hydrogenated alprenolol derivative where the extra hydrogens are often tritiated. This radiolabeled form of ALPRENOLOL, a beta-adrenergic blocker, is used to label the beta-adrenergic receptor for isolation and study.
MSH

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supratentoriální nádory

Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.
MSH

A benign or malignant neoplasm that occurs within the intracranial cavity above the tentorium cerebelli.
NCI

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micely

Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
MSH

aggregate of lipids in which the polar head groups face outward and the hydrophobic tails face inward.
CSP

A tiny particle made of substances that are soluble in water and that come together to form a ball-like shape. These particles can carry other substances inside them. In medicine, micelles are made in the laboratory and are used to carry drugs to body tissues and cells.
NCI

A multimolecular colloid particle, usually formed by amphipathic molecules in solution with the polar group toward the solution and the hydrophobic group toward the interior.
NCI

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Belgische haas

A strain of Oryctolagus cuniculus originating in Flanders, Belgium and perfected by English breeders.
MSH

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hypofýza – přední lalok

The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.
MSH

The glandular or anterior lobe of the pituitary gland which secretes several hormones.
NCI

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zdravotnická zařízení – plánování

Areawide planning for health care institutions on the basis of projected consumer need.
MSH

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dimethinden

A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
MSH

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chirurgické nástroje

Hand-held tools or implements used by health professionals for the performance of surgical tasks.
MSH

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mikroporézní filtry

A membrane or barrier with micrometer sized pores used for separation purification processes.
MSH

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benzethonium

Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
MSH

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plankton

Community of tiny aquatic PLANTS and ANIMALS, and photosynthetic BACTERIA, that are either free-floating or suspended in the water, with little or no power of locomotion. They are divided into PHYTOPLANKTON and ZOOPLANKTON.
MSH

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agentury pro zdravotnické systémy

Health planning and resources development agencies which function in each health service area of the United States (PL 93-641).
MSH

a department of government concerned with administering those agencies and offices having programs pertaining to health and health services.
CSP

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dipeptidy

Peptides composed of two amino acid units.
MSH

peptide that yields two molecules of amino acid on hydrolysis.
CSP

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prasata – nemoci

Diseases of domestic swine and of the wild boar of the genus Sus.
MSH

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midodrin

An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
MSH

A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
NCI

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befeniové sloučeniny

Analogs or derivatives of bephenium (N,N-dimethyl-N-(2-phenoxyethyl)benzenemethanaminium).
MSH

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Plasmodium berghei

protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.
CSP

A protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.
MSH

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srdeční frekvence fetální

The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.
MSH

The number of fetal cardiac beats per minute.
NCI

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disartikulace

Amputation or separation at a joint. (Dorland, 28th ed)
MSH

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syfilis kardiovaskulární

Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.
MSH

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Minocycline Hydrochloride

The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline`s neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.
NCI

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betain

A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
MSH

class of trimethyl derivatives of amino acids or the internal salts of quaternary ammonium bases.
CSP

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Pleomorphism

Having different forms at different stages of the life cycle.
NCI

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Hela buňky

first continuously cultured human malignant cell line, derived from a cervical carcinoma; used for virus cultivation and antitumor drug screening assays.
CSP

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
MSH

HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences. P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported. M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5. M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chromosome 11 and an arm of chromosome 19. HeLa Marker Chromosomes: One copy of Ml, one copy of M2, four-five copies of M3, and two copies of M4 as revealed by G-banding patterns.
NCI

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vzdálenost – percepce

The act of knowing or the recognition of a distance by recollective thought, or by means of a sensory process which is under the influence of set and of prior experience.
MSH

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Taenia

A genus of large tapeworms.
MSH

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mitóza

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
MSH

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division. [GOC:dph, GOC:mah, ISBN:0815316194]
GO

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
GO

The last cell cycle stage during which the replicated daughter chromosomes separate in to separate nuclei; cytokinesis then occurs to produce separate daughter cells. It is divided into Prophase, Metaphase, Anaphase, and Telophase.
NCI

The process by which a single parent cell divides to make two new daughter cells. Each daughter cell receives a complete set of chromosomes from the parent cell. This process allows the body to grow and replace cells.
NCI

The usual process of somatic reproduction of cells consisting of a sequence of modifications of the nucleus that result in the formation of two daughter cells with exactly the same chromosome and DNA content as that of the original cell. It is the process by which the body grows and replaces cells and is divided into four phases. In Prophase, paired chromosomes form, nuclear membrane disappears, the achromatic spindle appears, and polar bodies form. In Metaphase, chromosomes are arranged in the equatorial plane of the central spindle to form the monaster and chromosomes separate into exactly similar halves. In Anaphase, the two groups of daughter chromosomes separate and move along the fibers of the central spindle, each toward one of the asters, forming the diaster. In Telophase, the daughter chromosomes resolve themselves into a reticulum, the daughter nuclei are formed, and the cytoplasm divides forming two complete daughter cells.
NCI

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žlučové pigmenty

Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.
MSH

pigments that give a characteristic color to bile including: bilirubin, biliverdine, and bilicyanin.
CSP

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