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anilinhydroxylasa

A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.
MSH

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ferredoxin-NADP-reduktasa

An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of NADP. EC 1.18.1.2 was formerly listed as EC 1.6.7.1 and EC 1.6.99.4.
MSH

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páteř – nádory

A primary or metastatic neoplasm that occurs within the spinal canal including the spinal cord and surrounding paraspinal spaces.
NCI

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Criglerův-Najjarův syndrom

A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.
MSH

A rare autosomal recessive inherited syndrome characterized by abnormalities in the metabolism of bilirubin. It results in the development of jaundice. It may cause brain damage in infancy.
NCI

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lawrencium

Lawrencium. A radioactive actinide discovered in 1961. It has the atomic symbol Lr, atomic number 103, and atomic weight of 257. There are two isotopes with mass number 257 or 258, and mass number 256.
MSH

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parodontální chobot

An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.
MSH

An abnormal deepening of a gingival sulcus associated with destruction of the supporting periodontal tissue.
NCI

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hlezenní kloub

The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.
MSH

A gliding joint between the distal ends of the tibia and fibula and the proximal end of the talus. (NCI)
NCI

A gliding joint between the distal ends of the tibia and fibula and the proximal end of the talus.
NCI

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fétus – makrozomie

A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.
MSH

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slezina – nemoci

condition in which there is a deviation from or interruption of the normal structure or function of the spleen.
CSP

Your spleen is an organ above your stomach and under your ribs on your left side. It is about as big as your fist. The spleen is part of your lymphatic system, which fights infection and keeps your body fluids in balance. It contains white blood cells that fight germs. Your spleen also helps control the amount of blood in your body, and destroys old and damaged cells.

Certain diseases might cause your spleen to swell. You can also damage or rupture your spleen in an injury, especially if it is already swollen. If your spleen is too damaged, you might need surgery to remove it. You can live without a spleen. Other organs, such as your liver, will take over some of the spleen`s work. Without a spleen, however, your body will lose some of its ability to fight infections.


MEDLINEPLUS

A disorder of the spleen.
NCI

A non-neoplastic or neoplastic disorder affecting the spleen. Examples include infection, hemangioma, lymphoma, leukemia and angiosarcoma.
NCI

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Cruveilhierův-Baumgartenův syndrom

Liver cirrhosis with intrahepatic portal obstruction, HYPERTENSION, and patent UMBILICAL VEINS.
MSH

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legionářská nemoc

An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.
MSH

Legionnaires` disease is a type of pneumonia caused by bacteria. You usually get it by breathing in mist from water that contains the bacteria. The mist may come from hot tubs, showers or air-conditioning units for large buildings. The bacteria don`t spread from person to person.

Symptoms of Legionnaires` disease include fever, chills, a cough and sometimes muscle aches and headaches. Other types of pneumonia have similar symptoms. You will probably need a chest x-ray to diagnose the pneumonia. Lab tests can detect the specific bacteria that cause Legionnaires` disease.

The bacteria are more likely to make you sick if you

  • Are older than 65
  • Smoke
  • Have a lung disease
  • Have a weak immune system

Legionnaires` disease is serious and can be life-threatening. However, most people recover with antibiotic treatment.

Centers for Disease Control and Prevention


MEDLINEPLUS

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peroxidy

A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley`s Condensed Chemical Dictionary, 11th ed)
MSH

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anthralin

An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.
MSH

A natural anthraquinone derivative, anti-psoriatic and anti-inflammatory Anthralin (dithranol) controls skin growth by reducing DNA synthesis and mitotic activity in the hyperplastic epidermis, restoring a normal rate of cell proliferation and keratinization. Used topically in the treatment of psoriasis, dermatoses, and alopecia areata, it is also used in biomedical research due to its effect on EGFR autophosphorylation. (NCI04)
NCI

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fibrocystická nemoc prsu

A common condition marked by benign (not cancer) changes in breast tissue. These changes may include irregular lumps or cysts, breast discomfort, sensitive nipples, and itching. These symptoms may change throughout the menstrual cycle and usually stop after menopause.
NCI

A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.
MSH

Fibrosis associated with cyst formation in the breast parenchyma. — 2003
NCI

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Saint Helena Islands

Islands in the South Atlantic Ocean, about midway between South America and Africa. (NCI)
NCI

Islands in the South Atlantic Ocean, about midway between South America and Africa. (CIA World Factbook 2002)
NCI

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kurkumin

A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
MSH

A yellow pigment of the spice turmeric that is being studied in cancer prevention.
NCI

A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as tumeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent`s observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43115&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43115&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C401″ NCI Thesaurus)
PDQ

A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent`s observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04)
NCI

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implantace nitrooční čočky

Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.
MSH

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petechie

Pinpoint, unraised, round red spots under the skin caused by bleeding.
NCI

Pinpoint, flat, round red spots under the skin caused by bleeding
CHV

Purple or red pinpoint spots in the skin or mucous membranes caused by minor hemorrhage.
NCI

Pinhead size (3 mm) skin discolorization due to hemorrhage.
MSH

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antinukleární protilátky

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren`s syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
MSH

autoimmune, pathological antibodies against histones, DNA, nuclear RNA, or other components of the cell nucleus.
CSP

An autoimmune antibody that is directed against structures within the nucleus of the cell.
NCI

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finanční podpora

The provision of monetary resources including money or capital and credit; obtaining or furnishing money or capital for a purchase or enterprise and the funds so obtained. (From Random House Unabridged Dictionary, 2d ed.)
MSH

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státní lékařství

A system of medical care regulated, controlled and financed by the government, in which the government assumes responsibility for the health needs of the population.
MSH

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cyklohexanoly

Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
MSH

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leucin

An essential branched-chain amino acid important for hemoglobin formation.
MSH

essential branched-chain amino acid important for hemoglobin formation.
CSP

Amino acid with side chain -CH2CH(CH3)2.
NCI

One of nine essential amino acids in humans (provided by food), Leucine is important for protein synthesis and many metabolic functions. Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. Leucine is available in many foods and deficiency is rare. (NCI04)
NCI

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farynx – nemoci

Pathological processes involving the PHARYNX.
MSH

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antigen-protilátka komplex

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
MSH

product of an antigen antibody reaction; may also contain complement.
CSP

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hasicí látky

Materials applied to fabrics, bedding, furniture, plastics, etc. to retard their burning; many may leach out and cause allergies or other harm.
MSH

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steroid-21-hydroxylasa

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
MSH

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cystafos

Proposed as an adjuvant to cancer chemotherapy; may have radiation protective properties.
MSH

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leukémie pre-B-buněčná

A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.
MSH

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fenoxybenzamin

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
MSH

A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
NCI

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