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sigmoideum – nemoci

Pathological processes in the SIGMOID COLON region of the large intestine (INTESTINE, LARGE).
MSH

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menopauza předčasná

The premature cessation of menses (MENSTRUATION) when the last menstrual period occurs in a woman under the age of 40. It is due to the depletion of OVARIAN FOLLICLES. Premature MENOPAUSE can be caused by diseases; OVARIECTOMY; RADIATION; chemicals; and chromosomal abnormalities.
MSH

Ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive.
NCI

A loss of ovarian function in women under 40.
NCI

A disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive.
NCI

A condition in which the ovaries stop working and menstrual periods stop before age 40. Natural menopause usually occurs around age 50. A woman is said to be in menopause when she hasn`t had a period for 12 months in a row. Symptoms of menopause include hot flashes, mood swings, night sweats, vaginal dryness, trouble concentrating, and infertility. Premature menopause can be caused by some cancer treatments, surgery to remove the ovaries, and certain diseases or genetic conditions.
NCI

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kyselina dithionitrobenzoová

A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate.
MSH

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pankreas – transplantace

The transference of a pancreas from one human or animal to another.
MSH

transferring pancreatic cells or tissue, or whole pancreas, within an individual or between individuals of the same or different species; for specific pancreatic islet cells use PANCREATIC ISLET CELL TRANSPLANTATION.
CSP

The pancreas is an organ that makes insulin and enzymes that help the body digest and use food. A pancreas transplant is surgery to place a healthy pancreas from a donor into a person with a diseased pancreas. A common reason for this type of damage is diabetes. Pancreas transplants can enable people with type 1 diabetes to give up insulin shots. An experimental procedure called islet cell transplantation transplants only the parts of the pancreas that make insulin.

People who have transplants must take drugs to keep their body from rejecting the new pancreas for the rest of their lives. They must also have regular follow-up care.


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gonany

Steroids containing the fundamental tetracyclic unit with no methyl groups at C-10 and C-13 and with no side chain at C-17. The concept includes both saturated and unsaturated derivatives.
MSH

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biliverdin

1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone. Biosynthesized from hemoglobin as a precursor of bilirubin. Occurs in the bile of AMPHIBIANS and of birds, but not in normal human bile or serum.
MSH

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retroviry opic

Classes of retroviruses for which monkeys or apes are hosts. Those isolated from the West African green monkey and the Asian rhesus macaque monkey are of particular interest because of their similarities to viruses causing cancer and acquired immunodeficiency syndrome (AIDS) in humans.
MSH

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rtuť – otrava

acute or chronic disease produced by exposure to mercury or toxic mercury compounds.
CSP

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DNA-polymerasa I

A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3`-5` and 5`-3` exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
MSH

An enzyme that plays major roles in DNA metabolism. The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair. DNA polymerase alpha is most active in dividing cells, and is primarily involved with lagging strand synthesis.
NCI

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kyselina pantothenová

A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
MSH

A water-soluble vitamin ubiquitously found in plants and animal tissues with antioxidant property. Vitamin B5 is a component of coenzyme A (CoA) and a part of the vitamin B2 complex. Vitamin B5 is a growth factor and is essential for various metabolic functions, including the metabolism of carbohydrates, proteins, and fatty acids. This vitamin is also involved in the synthesis of cholesterol, lipids, neurotransmitters, steroid hormones, and hemoglobin.
NCI

Water-soluble vitamin that is a component of coenzyme A and phosphopantetheine, which are involved in fatty acid metabolism. (DRI)
NCI

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Pantothenic acid helps some enzymes use foods and make many substances used in the body and protects cells against damage from peroxides. It is found in almost all plant and animal foods. Pantothenic acid is water-soluble (can dissolve in water) and must be taken in every day.
NCI

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granulom

A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
MSH

relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
CSP

small lump caused by inflammation
CHV

An inflammatory reaction usually caused by infectious organisms, foreign bodies, or cholesterol deposits. It is characterized by the presence of epithelioid histiocytes and chronic inflammation. Often times giant cells are present. Necrosis is sometimes observed.
NCI

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biologické vědy

All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
MSH

The division of the natural sciences that is concerned with the phenomenon of life and vital processes.
NCI

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stárnutí kůže

The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
MSH

Your skin changes as you age. You might notice wrinkles, age spots and dryness. Your skin also becomes thinner and loses fat, making it less plump and smooth. It might take longer to heal, too.

Sunlight is a major cause of skin aging. You can protect yourself by staying out of the sun when it is strongest, using sunscreen with an SPF of 15 or higher, wearing protective clothing, and avoiding sunlamps and tanning beds. Cigarette smoking also contributes to wrinkles. The wrinkling increases with the amount of cigarettes and number of years a person has smoked.

Many products claim to revitalize aging skin or reduce wrinkles, but the Food and Drug Administration has approved only a few for sun-damaged or aging skin. Various treatments soothe dry skin and reduce the appearance of age spots.

NIH: National Institute on Aging


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metabolic aspects

Used with organs, cells and subcellular fractions, organisms, and diseases for biochemical changes and metabolism. It is used also with drugs and chemicals for catabolic changes (breakdown of complex molecules into simpler ones). For anabolic processes (conversion of small molecules into large), BIOSYNTHESIS is used. For enzymology, pharmacokinetics, and secretion use the specific subheadings.
MSH

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dolicholmonofosfátmannosa

A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.
MSH

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Paragonimus westermani

A species of lung fluke infecting humans and other animals, and found chiefly in Asia and the Far East.
MSH

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skupinová struktura

The informal or formal organization of a group of people based on a network of personal relationships which is influenced by the size and composition, etc., of the group.
MSH

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ptáci – nemoci

Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc.
MSH

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viry pomalé – infekce

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES.
MSH

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methakryláty

Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.
MSH

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doxycyklin

A synthetic TETRACYCLINE derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (MALARIA, FALCIPARUM).
MSH

A drug used to treat many types of bacterial infections. It stops the growth of bacteria by keeping them from making proteins. It is a type of antibiotic.
NCI

a kind of antibiotics
CHV

A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42494&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42494&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C457″ NCI Thesaurus)
PDQ

A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.
NCI

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paraquat

A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.
MSH

poisonous dipyridilium compound used as a contact herbicide.
CSP

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guanylcyklasa

An enzyme that catalyzes the conversion of GTP to 3`,5`-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.
MSH

Guanylate cyclase (GC) is an enzyme that converts GTP to the second messenger cyclic GMP (cGMP). There are two forms: plasma membrane GCs that are receptors for hormones, and intracellular soluble GCs that are activated by the gaseous second messenger nitric oxide (NO). EC 4.6.1.2
NCI

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močový měchýř – nádory

new abnormal urinary bladder tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

Tumors or cancer of the URINARY BLADDER.
MSH

A benign or malignant, primary or metastatic neoplasm of the bladder. – 2003
NCI

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sociální žádoucnost

A personality trait rendering the individual acceptable in social or interpersonal relations. It is related to social acceptance, social approval, popularity, social status, leadership qualities, or any quality making him a socially desirable companion.
MSH

personality trait rendering the individual acceptable in social or interpersonal relations; related to social acceptance, social approval, popularity, social status, or leadership qualities
CSP

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methohexital

An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
MSH

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léky – hodnocení

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
MSH

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Parkinsonova nemoc postencefalitická

Parkinsonism following encephalitis, historically seen as a sequella of encephalitis lethargica (Von Economo Encephalitis). The early age of onset, the rapid progression of symptoms followed by stabilization, and the presence of a variety of other neurological disorders (e.g., sociopathic behavior; TICS; MUSCLE SPASMS; oculogyric crises; hyperphagia; and bizarre movements) distinguish this condition from primary PARKINSON DISEASE. Pathologic features include neuronal loss and gliosis concentrated in the MESENCEPHALON; SUBTHALAMUS; and HYPOTHALAMUS. (From Adams et al., Principles of Neurology, 6th ed, p754)
MSH

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Haemonchus

A genus of parasitic nematode worms which infest the duodenum and stomach of domestic and wild herbivores, which ingest it with the grasses (POACEAE) they eat. Infestation of man is accidental.
MSH

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blood flow measurement

techniques used to measure velocity and amount of blood flow and circulation in the living system.
CSP

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