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Coombsův test

Hemagglutination test in which Coombs` reagent (antiglobulin, or anti-human globulin rabbit immune serum) is added to detect incomplete (non-agglutinating, univalent, blocking) antibodies coating erythrocytes. The direct test is applied to red cells which have been coated with antibody in vivo (e.g., in hemolytic disease of newborn, autoimmune hemolytic anemia, and transfusion reactions). The indirect test is applied to serum to detect the presence of antibody (e.g., in detection of incompatibility in cross-matching tests, detection and identification of irregular antibodies, and in detection of antibodies not identifiable by other means).
MSH

A laboratory test to identify antibodies that can bind to the surface of red blood cells or platelets and destroy them. This test is used to diagnose certain blood disorders in which patients make antibodies to their own red blood cells or platelets. It is also used to determine blood type.
NCI

Hemagglutination test in which Coombs` reagent (antiglobulin, or anti-human globulin rabbit immune serum) is added to detect incomplete (non-agglutinating, univalent, blocking) antibodies coating erythrocytes. The direct test is applied to red cells which have been coated with antibody in vivo (e.g., in hemolytic disease of newborn, autoimmune hemolytic anemia, and transfusion reactions). The indirect test is applied to serum to detect the presence of antibody (e.g., in detection of incompatibility in cross-matching tests, detection and identification of irregular antibodies, and in detection of antibodies not identifiable by other means). (MeSH)
NCI

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nervus lingualis

A sensory branch of the MANDIBULAR NERVE, which is part of the trigeminal (5th cranial) nerve. The lingual nerve carries general afferent fibers from the anterior two-thirds of the tongue, the floor of the mouth, and the mandibular gingivae.
MSH

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střídmost

Abstinence from alcohol.
MSH

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noha – dermatózy

Skin diseases of the foot, general or unspecified.
MSH

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kyselina polyglutamová

A peptide that is a homopolymer of glutamic acid.
MSH

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koronární jednotky

The hospital unit in which patients with acute cardiac disorders receive intensive care.
MSH

advanced and highly specialized care provided to medical or surgical patients with coronary disorders whose conditions are life-threatening and require comprehensive care and constant monitoring; it is usually administered in specially equipped units of a hospital.
CSP

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lipolýza

The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
MSH

decomposition or splitting up of fats or lipids.
CSP

The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]
GO

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péče o umírající

Medical and nursing care of patients in the terminal stage of an illness.
MSH

treatment of patients who are suffering from fatal, incurable illnesses; terminal patient care deals heavily with issues such as pain management and addressing the emotional and psychological needs of patient and family.
CSP

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anémie hemolytická kongenitální nesférocytární

Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. Common causes include deficiencies in GLUCOSE-6-PHOSPHATE ISOMERASE; PYRUVATE KINASE; and GLUCOSE-6-PHOSPHATE DEHYDROGENASE.
MSH

group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte; in some cases, pyruvate kinase deficiency has been demonstrated; in other cases, glucose-6-phosphate dehydrogenase deficiency has been demonstrated.
CSP

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formazany

Colored azo compounds formed by the reduction of tetrazolium salts. Employing this reaction, oxidoreductase activity can be determined quantitatively in tissue sections by allowing the enzymes to act on their specific substrates in the presence of tetrazolium salts.
MSH

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polyradikuloneuropatie

Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.
MSH

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kosmetické přípravky

Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body`s structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
MSH

Cosmetics are products you apply to your body to clean it, make it more attractive or change the way it looks. They include

  • Hair dyes
  • Makeup
  • Perfumes
  • Skin-care creams

Products such as dandruff shampoo, fluoride toothpaste and antiperspirant deodorant are both cosmetics and drugs. A good way to tell if you`re buying a cosmetic that is also a drug is to see if the first ingredient listed is an “active ingredient.” The active ingredient is the chemical that makes the product effective, and the manufacturer must have proof that it`s safe for its intended use. To find out all the ingredients in a cosmetic you use, check the container. Manufacturers are required to list them. Labels such as “natural” and “hypoallergenic” have no official meaning. Companies can use them to mean whatever they want.

Food and Drug Administration


MEDLINEPLUS

A substance that is intended to be applied to the body to promote attractiveness without affecting the body`s structure or functions.
NCI

An article intended to be rubbed, poured, sprinkled, or sprayed on or introduced into or otherwise applied to the human body for cleansing, beautifying, promoting attractiveness or altering the appearance.
NCI

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kyselina lithocholová

A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
MSH

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tetradekanoylforbolacetát

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
MSH

A substance being studied in the treatment of leukemias and lymphomas. It is also being studied in the treatment of other types of cancer. Tetradecanoylphorbol acetate affects many cell actions and may cause tumor cells to die. It is a type of phorbol ester.
NCI

A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43661&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43661&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C866″ NCI Thesaurus)
PDQ

A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)
NCI

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aneuploidie

The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
MSH

chromosomal constitution of cells which deviate from the normal by the addition or subtraction of chromosomes or chromosome pairs.
CSP

The occurrence of one or more extra or missing chromosomes leading to an unbalanced chromosome complement, or any chromosome number that is not an exact multiple of the haploid number (which is 46).
NCI

A chromosomal abnormality in which there is an addition or loss of chromosomes within a set (e.g., 23 + 22 or 23 + 24).
NCI

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syndrom fragilního X

A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
MSH

X-linked recessive disorder characterized by mental retardation and large head, jaw, ears, and testes; premutation alleles in unaffected carriers give rise to significantly amplified repeats in affected progeny.
CSP

Fragile X syndrome is the most common form of inherited mental retardation. A problem with a specific gene causes the disease. Normally, the gene makes a protein you need for brain development. But the mutation causes a person to make little or none of the protein, which results in the symptoms of Fragile X.

People with only a small change in the gene might not show any signs of Fragile X. People with bigger changes can have severe symptoms. These might include

  • Intelligence problems, ranging from learning disabilities to severe mental retardation
  • Social and emotional problems, such as aggression in boys or shyness in girls
  • Speech and language problems, especially in boys

Fragile X has no cure. You can treat some symptoms with educational, behavioral or physical therapy, and with medicines. Getting treatment early for Fragile X can help.

NIH: National Institute of Child Health and Human Development


MEDLINEPLUS

A genetic syndrome caused by mutations in the FMR1 gene which is responsible for the expression of the fragile X mental retardation 1 protein. This protein participates in neural development. This syndrome is manifested with mental, emotional, behavioral, physical, and learning disabilities.
NCI

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populace – surveillance

Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
MSH

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Coxsackie Viruses

cause herpangina, aseptic meningitis, pleurodynia, nyalgis, orchitis and myocarditis; divided into groups A and B on basis of disease signs in suckling mice.
CSP

Heterogeneous serotypes of various species in the genus ENTEROVIRUS, found in association with various diseases in man and other animals. The specific coxsackieviruses are distributed among the species HUMAN ENTEROVIRUS A; HUMAN ENTEROVIRUS B; and HUMAN ENTEROVIRUS C. The name is derived from a village in New York State where the virus was first identified.
MSH

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lokální počítačové sítě

Communications networks connecting various hardware devices together within or between buildings by means of a continuous cable or voice data telephone system.
MSH

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thalium – radioisotopy

Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
MSH

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anilinhydroxylasa

A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.
MSH

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fruktokinasy

A class of enzymes that catalyzes the phosphorylation of fructose in the presence of ATP. EC 2.7.1.-.
MSH

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ERDITZE ONDORENGO ODOLJARIO GARRANTZITSUA

Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
MSH

Hemorrhage defined as a blood loss in excess of 500 mL after vaginal delivery or more than 1000 mL after a cesarean delivery.
NCI

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Criglerův-Najjarův syndrom

A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.
MSH

A rare autosomal recessive inherited syndrome characterized by abnormalities in the metabolism of bilirubin. It results in the development of jaundice. It may cause brain damage in infancy.
NCI

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Krvácení v dolní části zažívacího traktu

Bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).
NCI

A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).
NCI

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elektroencefalografie – theta rytmus

Brain waves characterized by a frequency of 4-7 Hz, usually observed in the temporal lobes when the individual is awake, but relaxed and sleepy.
MSH

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hlezenní kloub

The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.
MSH

A gliding joint between the distal ends of the tibia and fibula and the proximal end of the talus. (NCI)
NCI

A gliding joint between the distal ends of the tibia and fibula and the proximal end of the talus.
NCI

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furagin

Nitrofuran derivative anti-infective agent used for urinary tract infections.
MSH

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praktolol

A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
MSH

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Cruveilhierův-Baumgartenův syndrom

Liver cirrhosis with intrahepatic portal obstruction, HYPERTENSION, and patent UMBILICAL VEINS.
MSH

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