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léky – hodnocení

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
MSH

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nikotinamidasa

An enzyme that catalyzes the hydrolysis of nicotinamide to nicotinate and ammonia. EC 3.5.1.19.
MSH

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blood flow measurement

techniques used to measure velocity and amount of blood flow and circulation in the living system.
CSP

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tetradekanoylforbolacetát

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
MSH

A substance being studied in the treatment of leukemias and lymphomas. It is also being studied in the treatment of other types of cancer. Tetradecanoylphorbol acetate affects many cell actions and may cause tumor cells to die. It is a type of phorbol ester.
NCI

A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43661&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43661&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C866″ NCI Thesaurus)
PDQ

A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)
NCI

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hypotalamus – nemoci

Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; AUTONOMIC NERVOUS SYSTEM DISEASES; SLEEP DISORDERS; behavioral symptoms related to dysfunction of the LIMBIC SYSTEM; and neuroendocrine disorders.
MSH

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populace – surveillance

Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
MSH

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Duchenneova svalová dystrofie

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
MSH

An X-linked inherited disorder caused by mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.
NCI

a kind of inherited disorder, characterized by rapidly-worsening muscle weakness
CHV

X-linked recessive muscle disease caused by an inability to synthesize dystrophin, which is involved with maintaining the integrity of the sarcolemma; muscle fibers undergo a process that features degeneration and regeneration; clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy and an increased incidence of impaired mentation; Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course.
CSP

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nitrakrin

Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
MSH

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krevní transfúze autologní

Reinfusion of blood or blood products derived from the patient`s own circulation. (Dorland, 27th ed)
MSH

reinfusion of blood or blood products derived from the patient`s own circulation.
CSP

Infusion of previously obtained autologous blood or blood products back to the same individual.
NCI

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thalium – radioisotopy

Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
MSH

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ibuprofen

A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
MSH

nonsteroidal analgesic, antipyretic and anti-inflammatory agent that is a propionic acid derivative.
CSP

a chemical substance
CHV

A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
NCI

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C561″ NCI Thesaurus)
PDQ

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)
NCI

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ERDITZE ONDORENGO ODOLJARIO GARRANTZITSUA

Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
MSH

Hemorrhage defined as a blood loss in excess of 500 mL after vaginal delivery or more than 1000 mL after a cesarean delivery.
NCI

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primární dysautonomie

An acute or chronic disorder, affecting the sympathetic or parasympathetic nervous system. It can be primary, the result of central nervous system degeneration, or secondary due to diabetes or alcoholism. Patients with the chronic form of this disorder usually have a progressive clinical course and a poor prognosis.
NCI

Disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a primary condition. Manifestations can involve any or all body systems but commonly affect the BLOOD PRESSURE and HEART RATE.
MSH

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nitrofenylgalaktosidy

Includes ortho-, meta-, and para-nitrophenylgalactosides.
MSH

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tělo – velikost

The physical measurements of a body.
MSH

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elektroencefalografie – theta rytmus

Brain waves characterized by a frequency of 4-7 Hz, usually observed in the temporal lobes when the individual is awake, but relaxed and sleepy.
MSH

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ileum

The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
MSH

distal part of the small intestine, extending from the jejunum to the cecum.
CSP

The final section of the small intestine. (NCI)
NCI

The final section of the small intestine.
NCI

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praktolol

A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
MSH

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bolest ucha

Pain in the ear.
MSH

A disorder characterized by a sensation of marked discomfort in the ear.
NCI

Painful sensation in the ear region.
NCI

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nonachlazin

Coronary vasodilator with a novel mechanism of action; proposed as antianginal agent.
MSH

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kosti – nádory

Tumors or cancer located in bone tissue or specific BONES.
MSH

new abnormal bone tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; includes tumors or cancer located in bone tissue or specific bones.
CSP

A benign or malignant (primary or metastatic) tumor involving the bone. Common malignant tumor types involving the bones are metastatic carcinomas and sarcomas. — 2003
NCI

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thiogalaktosidy

Galactosides in which the oxygen atom linking the sugar and aglycone is replaced by a sulfur atom.
MSH

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imunita aktivní

Resistance to a disease agent resulting from the production of specific antibodies by the host, either after exposure to the disease or after vaccination.
MSH

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těhotenství – komplikace nádorové

The co-occurrence of pregnancy and NEOPLASMS. The neoplastic disease may precede or follow FERTILIZATION.
MSH

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echovirus 9

A species of ENTEROVIRUS associated with outbreaks of aseptic meningitis (MENINGITIS, ASEPTIC).
MSH

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Borrelia burgdorferi

A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.
MSH

A species of bacteria within the phylum Spirochaetes that is the causative agent of Lyme disease.
NCI

Any bacterial organism that can be assigned to the species Borrelia burgdorferi.
NCI

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hrudní chirurgie

A surgical specialty concerned with diagnosis and treatment of disorders of the heart, lungs, and esophagus. Two major types of thoracic surgery are classified as pulmonary and cardiovascular.
MSH

A branch of medicine dealing with the use of surgery to treat diseases of the chest and lungs. (On-line Medical Dictionary)
NCI

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imunoglobuliny – Fab fragmenty

Part of an immunoglobulin antibody that binds a specific antigen and consists of both a light chain and part of a heavy chain. By comparison, natural antibodies consist of two heavy and two light chains. An FAB (fragment antibody) offers the advantages of smaller size and lower cross-reactivity compared to the complete antibody. (NCI04)
NCI

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
MSH

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předsudek

A preconceived judgment made without adequate evidence and not easily alterable by presentation of contrary evidence.
MSH

attitude or opinion which predisposes an individual to make a preconceived judgment prior to objective evaluation; frequently an irrational attitude of hostility directed against an individual, group, or race or their supposed characteristics; do not confuse with BIAS.
CSP

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edém

Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
MSH

swelling from excessive accumulation of serous fluid in tissue.
CSP

Swelling caused by excess fluid in body tissues.
NCI

Edema means swelling caused by fluid in your body`s tissues. It usually occurs in the feet, ankles and legs, but it can involve your entire body.

Causes of edema include

To keep swelling down, your health care provider may recommend keeping your legs raised when sitting, wearing support stockings, limiting how much salt you eat or taking a medicine called a diuretic – also called a water pill.


MEDLINEPLUS

Pathological transudate within one or more tissues.
UWDA

Accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
NCI

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