Shopping Page. Buy or upgrade website.

hypertelorismus

Abnormal increase in the interorbital distance due to overdevelopment of the lesser wings of the sphenoid.
MSH

Price: $1.00

Loading Updating cart…

Alternaria

A mitosporic Loculoascomycetes fungal genus including several plant pathogens and at least one species which produces a highly phytotoxic antibiotic. Its teleomorph is Lewia.
MSH

Price: $1.00

Loading Updating cart…

kokain

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
MSH

alkaloid ester extracted from the leaves of plants including coca; has powerful central nervous system effects similar to the amphetamines and is a drug of abuse; acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake; it is also a local anesthetic and vasoconstrictor and is clinically used for that purpose.
CSP

Cocaine is a powerful drug that stimulates the brain. People who use it can form a strong addiction. They may have to use more and more of the drug to get high. It`s sold on the street as a fine, white powder. There are two forms of cocaine: hydrochloride salt and freebase. The salt dissolves in water. People can take it in a vein or in the nose. The freebase form can be smoked. Crack is the street name of a smokable form of cocaine.

No matter how cocaine is taken, it is dangerous. Some of the most common serious problems include

  • Heart problems, including heart attacks
  • Respiratory effects, including respiratory failure
  • Nervous system problems, including strokes
  • Digestive problems

Any of these can be fatal. Using cocaine with alcohol is a common cause of drug-related death.

NIH: National Institute on Drug Abuse


MEDLINEPLUS

A tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.
NCI

Price: $1.00

Loading Updating cart…

Raynaudova nemoc

intermittent attacks of ischemia in the fingers, toes, ears, or nose, accompanied by pain, pallor, and prickling; phenomenon applies to secondary symptoms, disease when cause is unknown.
CSP

Raynaud`s disease is a rare disorder of the blood vessels, usually in the fingers and toes. People with this disorder have attacks that cause the blood vessels to narrow. When this happens, blood can`t get to the surface of the skin and the affected areas turn white and blue. When the blood flow returns, the skin turns red and throbs or tingles. In severe cases, loss of blood flow can cause sores or tissue death. Cold weather and stress can trigger attacks. Often the cause of Raynaud`s is not known. People in colder climates are more likely to develop Raynaud`s than people in warmer areas.

Treatment for Raynaud`s may include drugs to keep the blood vessels open. There are also simple things you can do yourself, such as

  • Soaking hands in warm water at the first sign of an attack
  • Keeping your hands and feet warm in cold weather

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

blood vessel disease that causes exaggerated responses to cold and stress with poor blood circulation
CHV

An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
MSH

An idiopathic vascular disorder characterized by ischemic attacks in the fingers, toes, ears, or nose, associated with pain and pallor. The attacks occur during exposure to cold temperatures or stress.
NCI

Price: $1.00

Loading Updating cart…

New Caledonia

A group of islands in Melanesia constituting a French overseas territory. The group includes New Caledonia (the main island), Ile des Pins, Loyalty Island, and several other islet groups. The capital is Noumea. It was discovered by Captain Cook in 1774 and visited by various navigators, explorers, and traders from 1792 to 1840. Occupied by the French in 1853, it was set up as a penal colony 1864-94. In 1946 it was made a French overseas territory. It was named by Captain Cook with the 5th and 6th century A.D. Latin name for Scotland, Caledonia. (From Webster`s New Geographical Dictionary, 1988, p830 & Room, Brewer`s Dictionary of Names, 1992, p375)
MSH

A country in the Pacific, comprised of islands in the South Pacific Ocean, east of Australia. (NCI)
NCI

A country in the Pacific, comprised of islands in the South Pacific Ocean, east of Australia. (CIA World Factbook 2002)
NCI

Price: $1.00

Loading Updating cart…

HIPOGLIZEMIA

A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
MSH

syndrome of abnormally low blood glucose level; clinical hypoglycemia has diverse etiologies; severe hypoglycemia eventually lead to glucose deprivation of the central nervous system resulting in hunger, sweating, paresthesia, impaired mental function, seizures, coma, and even death.
CSP

Abnormally low blood sugar.
NCI

Did you know you have sugar in your blood? Your body needs glucose, a form of sugar, to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn`t, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include

  • Hunger
  • Shakiness
  • Dizziness
  • Confusion
  • Difficulty speaking
  • Feeling anxious or weak

Hypoglycemia is usually a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan.

You can also have low blood sugar without having diabetes. In that case, your health care provider will try to find the cause using laboratory tests to measure blood glucose, insulin and other chemicals that play a part in the body`s use of energy.


MEDLINEPLUS

A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.
NCI

Abnormally low level of glucose in the blood.
NCI

Price: $1.00

Loading Updating cart…

Ambystoma

A genus of the Ambystomatidae family. The best known species are the axolotl AMBYSTOMA MEXICANUM and the closely related tiger salamander Ambystoma tigrinum. They may retain gills and remain aquatic without developing all of the adult characteristics. However, under proper changes in the environment they metamorphose.
MSH

Price: $1.00

Loading Updating cart…

koenzymy

Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.
MSH

synthetic or natural chemical compounds which resemble naturally occurring coenzymes in structure and/or function.
CSP

Price: $1.00

Loading Updating cart…

receptory buněčného povrchu

Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
MSH

cell surface proteins that bind signaling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell; not all cell surface receptors are tree`d under this term.
CSP

A receptor protein that is localized to the plasma membrane and may have exposure to the extracellular milieu.
NCI

Price: $1.00

Loading Updating cart…

kyselina niflumová

An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
MSH

Price: $1.00

Loading Updating cart…

hypotermie indukovaná

Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
MSH

abnormally low body temperature intentionally induced in warm-blooded animals by artificial means.
CSP

Price: $1.00

Loading Updating cart…

aminace

The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
MSH

creation of an amine by the addition of an amino group to an organic compound or reduction of a nitro group.
CSP

Price: $1.00

Loading Updating cart…

kolagen

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
MSH

principle protein of connective tissue; unusual absence of sulfur aminoacids; unique presence of hydroxyproline is believed to permit a triple helical fibrous structure.
CSP

A fibrous protein found in cartilage and other connective tissue.
NCI

A family of large fibrous proteins that are the main components of connective tissue and are responsible for maintaining tissue structure.
NCI

Price: $1.00

Loading Updating cart…

receptory serotoninové

Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
MSH

diverse family of receptors that mediate the effects of serotonin on neurons, lymphocytes, and other cells; in neurons, serotonin can be either excitatory or inhibitory; some serotonin receptors are G protein coupled.
CSP

Price: $1.00

Loading Updating cart…

dusitany

Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

the anion NO2-.
CSP

Price: $1.00

Loading Updating cart…

Idaho

A state in the northern Rocky Mountains of western United States. Its capital is Boise.
NCI

Price: $1.00

Loading Updating cart…

kyselina aminolevulová

A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
MSH

The active ingredient in a drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent.
NCI

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C234″ NCI Thesaurus)
PDQ

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. (NCI04)
NCI

Price: $1.00

Loading Updating cart…

jednotky formování kolonií – testy

A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.
MSH

Price: $1.00

Loading Updating cart…

nucleus ruber

A pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.
MSH

pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum receiving a large projection from the contralateral half of the cerebellum via the superior cerebellar peduncle and a projection from the ipsilateral motor cortex.
CSP

Price: $1.00

Loading Updating cart…

nitrosomočovinové sloučeniny

An anticancer drug that can cross the blood-brain barrier. Carmustine and lomustine are nitrosoureas.
NCI

Any of a class of alkylating agents that contain both a nitroso group and a urea. They are lipophilic and can cross the blood-brain barrier.
NCI

Price: $1.00

Loading Updating cart…

obraz – interpretace počítačová

Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
MSH

Price: $1.00

Loading Updating cart…

amodiachin

A 4-aminoquinoline compound with anti-inflammatory properties.
MSH

An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.
NCI

Price: $1.00

Loading Updating cart…

komunikace

The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.
MSH

exchange or transmission of thoughts, messages, or information, as by speech, signals, writing, or behavior.
CSP

The exchange of information between objects, people, or groups.
NCI

Price: $1.00

Loading Updating cart…

regresní analýza

Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
MSH

Regression analysis provides a “best-fit” mathematical equation for the relationship between the dependent variable (response) and independent variable(s) (covariates). There are two major classes of regression – parametric and non-parametric. Parametric regression requires choice of the regression equation with one or a greater number of unknown parameters. Linear regression, in which a linear relationship between the dependent variable and independent variables is posited, is an example. The aim of parametric regression is to find the values of these parameters which provide the best fit to the data. The number of parameters is usually much smaller than the number of data points. In contrast, the non-parametric regression requires no such a choice of the regression equation. (Statistics.com Glossary)
NCI

Price: $1.00

Loading Updating cart…

kyselina nordihydroguaiaretová

A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.
MSH

A naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. Nordihydroguaiaretic acid (NDGA) directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=479648&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=479648&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C701″ NCI Thesaurus)
PDQ

Price: $1.00

Loading Updating cart…

imunoanalýza

A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
MSH

Immunoassay


HL7V3.0

Price: $1.00

Loading Updating cart…

amyloidóza

A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
MSH

any disease manifested by the pathogenic accumulation of amyloid in organs and tissues.
CSP

A group of diseases in which protein builds up in certain organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause), secondary (caused by another disease, including some types of cancer, such as multiple myeloma), or hereditary (passed down from parents to children). Many organs are affected by amyloidosis. The organs affected may depend on whether the amyloidosis is the primary, secondary, or hereditary form.
NCI

A group of diseases in which protein is deposited in specific organs or throughout the body.
CHV

Amyloidosis occurs when abnormal proteins build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

There are three main types of amyloidosis:

  • Primary – with no known cause
  • Secondary – caused by another disease, including some types of cancer
  • Familial – passed down through genes

Treatment depends on the type of amyloidosis you have.


MEDLINEPLUS

A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
NCI

Price: $1.00

Loading Updating cart…

komplement C1s

A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
MSH

Price: $1.00

Loading Updating cart…

nemocnice náboženských organizací

Private hospitals that are owned or sponsored by religious organizations.
MSH

Price: $1.00

Loading Updating cart…

imunohistochemie

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
MSH

Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
NCI

A technique used to identify specific molecules in different kinds of tissue. The tissue is treated with antibodies that bind the specific molecule. These are made visible under a microscope by using a color reaction, a radioisotope, colloidal gold, or a fluorescent dye. Immunohistochemistry is used to help diagnose diseases, such as cancer, and to detect the presence of microorganisms. It is also used in basic research to understand how cells grow and differentiate (become more specialized).
NCI

Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
NCI

Price: $1.00

Loading Updating cart…

Comments are closed