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5,7-dihydroxytryptamin

Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.
MSH

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hematopoéza extramedulární

The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.
MSH

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progerie

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
MSH

a disease that produces rapid aging, beginning in childhood
CHV

A very rare genetic disorder caused by mutations in the LMNA gene. It is characterized by premature aging. Signs and symptoms include failure to thrive, limited growth, alopecia, wrinkled skin, small face, development of atherosclerosis, and heart disease. There is no cure for this condition. Individuals do not usually survive beyond their early twenties. Death usually occurs as a result of complications from atherosclerosis.
NCI

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DNA-polymerasa I

A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3`-5` and 5`-3` exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
MSH

An enzyme that plays major roles in DNA metabolism. The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair. DNA polymerase alpha is most active in dividing cells, and is primarily involved with lagging strand synthesis.
NCI

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Mollusca

phylum of the kingdom Metazoa; organisms have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot; most are encased in a protective calcareous shell; includes the classes Gastropoda, Bivalvia, Cephalopoda, Aplacophora, Scaphopoda, Polyplacophora, and Monoplacophora.
CSP

A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora.
MSH

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biologické vědy

All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
MSH

The division of the natural sciences that is concerned with the phenomenon of life and vital processes.
NCI

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břicho – nádory

new abnormal abdominal tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

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hemoglobin A glykosylovaný

Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
MSH

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Povýšení

Encouragement of the progress or growth or acceptance of something.
NCI

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dolicholmonofosfátmannosa

A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.
MSH

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proteiny přenášející monosacharidy

A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.
MSH

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ptáci – nemoci

Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc.
MSH

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kyselina abscisová

Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.
MSH

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virus Junin

A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. The disease is characterized by congestion, edema, generalized lymphadenopathy and hemorrhagic necrosis and is sometimes fatal.
MSH

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proporcionální rizikové modely

Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
MSH

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doxycyklin

A synthetic TETRACYCLINE derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (MALARIA, FALCIPARUM).
MSH

A drug used to treat many types of bacterial infections. It stops the growth of bacteria by keeping them from making proteins. It is a type of antibiotic.
NCI

a kind of antibiotics
CHV

A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42494&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42494&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C457″ NCI Thesaurus)
PDQ

A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.
NCI

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viry mozaiky

Viruses which produce a mottled appearance of the leaves of plants.
MSH

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močový měchýř – nádory

new abnormal urinary bladder tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

Tumors or cancer of the URINARY BLADDER.
MSH

A benign or malignant, primary or metastatic neoplasm of the bladder. – 2003
NCI

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účetnictví

System of recording financial transactions.
MSH

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hepatitida A

INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.
MSH

inflammation of the liver due to microorganism infection.
CSP

hepatitis caused by Hepatovirus (Hepatitis A virus); it can be transmitted through fecal contamination of food or water.
CSP

Acute inflammation of the liver caused by the hepatitis A virus. It is highly contagious and usually contracted through close contact with an infected individual or their feces, contaminated food or water.
NCI

Hepatitis A is one type of hepatitis – a liver disease – caused by the hepatitis A virus (HAV). The disease is spread primarily through food or water contaminated by stool from an infected person. You can get HAV from

  • Eating food prepared by someone with HAV who did not wash their hands after using the bathroom
  • Having anal/oral sex with someone with HAV
  • Not washing your hands after changing a diaper
  • Drinking contaminated water

HAV can cause swelling of the liver, but it rarely causes lasting damage. You may feel as if you have the flu, or you may have no symptoms at all. It usually gets better on its own after several weeks.

The hepatitis A vaccine can prevent HAV. Healthy habits also make a difference. Wash your hands thoroughly before preparing food, after using the toilet or after changing a diaper. International travelers should be careful about drinking tap water.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

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prostaglandiny F syntetické

Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.
MSH

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léky – hodnocení

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
MSH

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dentice – fyziologické jevy

Physiological processes and properties of the DENTITION.
MSH

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blood flow measurement

techniques used to measure velocity and amount of blood flow and circulation in the living system.
CSP

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kyselina acetrizoová

An iodinated radiographic contrast medium used as acetrizoate sodium in HYSTEROSALPINGOGRAPHY.
MSH

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kyseliny heptylové

7-carbon saturated monocarboxylic acids.
MSH

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proteinkinasa závislá na cyklickém AMP – typ II

A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. They are tetrameric proteins that contain two catalytic subunits and two type II-specific regulatory subunits.
MSH

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Duchenneova svalová dystrofie

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
MSH

An X-linked inherited disorder caused by mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.
NCI

a kind of inherited disorder, characterized by rapidly-worsening muscle weakness
CHV

X-linked recessive muscle disease caused by an inability to synthesize dystrophin, which is involved with maintaining the integrity of the sarcolemma; muscle fibers undergo a process that features degeneration and regeneration; clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy and an increased incidence of impaired mentation; Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course.
CSP

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multiinstitucionální systémy

Institutional systems consisting of more than one health facility which have cooperative administrative arrangements through merger, affiliation, shared services, or other collective ventures.
MSH

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krevní transfúze autologní

Reinfusion of blood or blood products derived from the patient`s own circulation. (Dorland, 27th ed)
MSH

reinfusion of blood or blood products derived from the patient`s own circulation.
CSP

Infusion of previously obtained autologous blood or blood products back to the same individual.
NCI

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