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antimetabolity

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)
MSH

drug that is chemically similar to a naturally occurring metabolite, but differs enough to interfere with normal metabolic pathways.
CSP

A drug that is very similar to natural chemicals in a normal biochemical reaction in cells but different enough to interfere with the normal division and functions of cells.
NCI

An antineoplastic agent with a structural similarity to a natural substance that can replace that substance in a normal biochemical pathway and interfere with the normal metabolic processes of cells.
NCI

An antimetabolite with an unknown or unspecified mechanism of action.
NCI

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laryngální svaly

The striated muscle groups which move the LARYNX as a whole or its parts, such as altering tension of the VOCAL CORDS, or size of the slit (RIMA GLOTTIDIS).
MSH

intrinsic muscles of the larynx are the vocal, aryepiglottic, arytenoid, cricoarytenoid, cricothyroid, thyroarytenoid, and thyroepiglottic.
CSP

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2-naftylamin

A naphthalene derivative with carcinogenic action.
MSH

A synthetic, air-sensitive, colorless crystalline solid that is soluble in hot water, alcohol, ether and many organic solvents. Currently, it is only used in laboratory research. Because the commercial production and use of 2-naphthylamine are banned, the potential for human exposure is low. The general population may be exposed to this chemical through inhalation of emissions from sources where nitrogen-containing organic matter is burned, such as coal furnaces and cigarettes. At greatest risk of occupational exposure to 2-naphthylamine are laboratory technicians and scientists who use it in research. Acute inhalation exposure to high levels of 2-naphthylamine can result in methemoglobinemia, dyspnea, ataxia, hematuria, dysuria and hemorrhagic cystitis. It is known to be a human carcinogen. (NCI05)
NCI

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ferredoxin-NADP-reduktasa

An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of NADP. EC 1.18.1.2 was formerly listed as EC 1.6.7.1 and EC 1.6.99.4.
MSH

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prokain

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
MSH

local anesthetic of the ester type that has a slow onset and a short duration of action, mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
CSP

A benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
NCI

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cytidindifosfát

Cytidine 5`-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate.
MSH

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antitrichomonádové látky

Agents used to treat trichomonas infections.
MSH

Any agent that can kill and/or inhibit the growth of anaerobic protists of Trichomonas genus.
NCI

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lawrencium

Lawrencium. A radioactive actinide discovered in 1961. It has the atomic symbol Lr, atomic number 103, and atomic weight of 257. There are two isotopes with mass number 257 or 258, and mass number 256.
MSH

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5,7-dihydroxytryptamin

Tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool.
MSH

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fétus – makrozomie

A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.
MSH

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progerie

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
MSH

a disease that produces rapid aging, beginning in childhood
CHV

A very rare genetic disorder caused by mutations in the LMNA gene. It is characterized by premature aging. Signs and symptoms include failure to thrive, limited growth, alopecia, wrinkled skin, small face, development of atherosclerosis, and heart disease. There is no cure for this condition. Individuals do not usually survive beyond their early twenties. Death usually occurs as a result of complications from atherosclerosis.
NCI

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Cellular aspects of

Used for cellular appearance of unicellular and multicellular organisms.
MSH

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aortitida

Inflammation of the wall of the AORTA.
MSH

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legionářská nemoc

An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.
MSH

Legionnaires` disease is a type of pneumonia caused by bacteria. You usually get it by breathing in mist from water that contains the bacteria. The mist may come from hot tubs, showers or air-conditioning units for large buildings. The bacteria don`t spread from person to person.

Symptoms of Legionnaires` disease include fever, chills, a cough and sometimes muscle aches and headaches. Other types of pneumonia have similar symptoms. You will probably need a chest x-ray to diagnose the pneumonia. Lab tests can detect the specific bacteria that cause Legionnaires` disease.

The bacteria are more likely to make you sick if you

  • Are older than 65
  • Smoke
  • Have a lung disease
  • Have a weak immune system

Legionnaires` disease is serious and can be life-threatening. However, most people recover with antibiotic treatment.

Centers for Disease Control and Prevention


MEDLINEPLUS

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břicho – nádory

new abnormal abdominal tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

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fibrocystická nemoc prsu

A common condition marked by benign (not cancer) changes in breast tissue. These changes may include irregular lumps or cysts, breast discomfort, sensitive nipples, and itching. These symptoms may change throughout the menstrual cycle and usually stop after menopause.
NCI

A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.
MSH

Fibrosis associated with cyst formation in the breast parenchyma. — 2003
NCI

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Povýšení

Encouragement of the progress or growth or acceptance of something.
NCI

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Dandyův-Walkerův syndrom

A congenital abnormality of the central nervous system marked by failure of the midline structures of the cerebellum to develop, dilation of the fourth ventricle, and upward displacement of the transverse sinuses, tentorium, and torcula. Clinical features include occipital bossing, progressive head enlargement, bulging of anterior fontanelle, papilledema, ataxia, gait disturbances, nystagmus, and intellectual compromise. (From Menkes, Textbook of Child Neurology, 5th ed, pp294-5)
MSH

A rare congenital brain malformation disorder characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilatation of the fourth ventricle, and enlargement of the posterior fossa.
NCI

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apendix – nádory

Tumors or cancer of the APPENDIX.
MSH

A benign or malignant neoplasm involving the appendix.
NCI

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implantace nitrooční čočky

Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.
MSH

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kyselina abscisová

Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.
MSH

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finanční podpora

The provision of monetary resources including money or capital and credit; obtaining or furnishing money or capital for a purchase or enterprise and the funds so obtained. (From Random House Unabridged Dictionary, 2d ed.)
MSH

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proporcionální rizikové modely

Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
MSH

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debridement

The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)
MSH

A procedure to remove dead tissue or foreign material from a wound to expose underlying healthy tissue and to promote healing.
NCI

surgical removal of foreign material and dead tissue from a wound in order to prevent infection and promote healing
CHV

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arachidonát-5-lipoxygenasa

An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
MSH

Arachidonate 5-lipoxygenase protein (674 aa, ~78 kDa) is encoded by the human ALOX5 gene. This protein plays a role in the synthesis of leukotrienes from arachidonic acid; thus, it mediates both inflammation and allergen responses.
NCI

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leucin

An essential branched-chain amino acid important for hemoglobin formation.
MSH

essential branched-chain amino acid important for hemoglobin formation.
CSP

Amino acid with side chain -CH2CH(CH3)2.
NCI

One of nine essential amino acids in humans (provided by food), Leucine is important for protein synthesis and many metabolic functions. Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. Leucine is available in many foods and deficiency is rare. (NCI04)
NCI

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účetnictví

System of recording financial transactions.
MSH

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hasicí látky

Materials applied to fabrics, bedding, furniture, plastics, etc. to retard their burning; many may leach out and cause allergies or other harm.
MSH

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prostaglandiny F syntetické

Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.
MSH

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deferoxamin

Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
MSH

natural product isolated from Streptomyces pilosus; it forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
CSP

An iron-chelating agent that removes iron from tumors by inhibiting DNA synthesis and causing cancer cell death. It is used in conjunction with other anticancer agents in pediatric neuroblastoma therapy.
NCI

An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)
NCI

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