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utonutí neúplné

Non-fatal immersion or submersion in water. The subject is resuscitable.
MSH

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talasémie alfa

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.
MSH

A genetic hematologic disorder characterized by partial or complete absence of the alpha globin chains of the heme molecule.
NCI

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vyhasnutí profesionální

An excessive stress reaction to one`s occupational or professional environment. It is manifested by feelings of emotional and physical exhaustion coupled with a sense of frustration and failure.
MSH

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Deltaretrovirus – infekce

Infections caused by the HTLV or BLV deltaretroviruses. They include human T-cell leukemia-lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED).
MSH

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potkani – mutantní kmeny

Rats bearing mutant genes which are phenotypically expressed in the animals.
MSH

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embryonální indukce

The complex processes of initiating CELL DIFFERENTIATION in the embryo. The precise regulation by cell interactions leads to diversity of cell types and specific pattern of organization (EMBRYOGENESIS).
MSH

A process that stimulates and directs a morphogenetic influence on a population of cells. These populations are often differentiating cells or adjacent neighboring cells that are not fixed on a developmental path. Embryonic induction plays a regulatory role in the development and construction of embryos.
NCI

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zinostatin

An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
MSH

antitumor protein possessing a regulatory function on the metabolism of DNA; also a potent cytostatic agent active against gram-positive bacteria.
CSP

a kind of cancer treatment drug
CHV

An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39510&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39510&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C682″ NCI Thesaurus)
PDQ

An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04)
NCI

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Ambenonium

A bisquaternary ammonium alcohol with parasympathomimetic activity. The positive charge of ambenonium allows it to act as an acetylcholinesterase inhibitor by binding to the anionic site at the reactive center of acetylcholinesterase, preventing the breakdown of acetylcholine and producing an indirect cholinomimetic effect at both nicotinic and muscarinic receptors. Ambenonium also has direct agonist activity at nicotinic receptors, potentiating the cholinomimetic effect at the neuromuscular junction.
NCI

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DNA komplementární

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
MSH

single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase; used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
CSP

Single-stranded DNA that is complementary to messenger RNA or DNA that has been synthesized from messenger RNA by reverse transcriptase.
NCI

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hydantoiny

Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.
MSH

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receptory cholecystokininu

Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.
MSH

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enalapril

One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.
MSH

1-carboxy-3-phenylpropyl-L-alanyl- L-proline (as 1`-ethyl ester, maleate 1:1), is an ACE inhibitor used as an antihypertensive.
CSP

A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
NCI

An antihypertensive agent that can also be used to slow or prevent the progression of heart disease in people with childhood cancer treated with drugs that may be harmful to the heart.
NCI

a drug used to treat hypertension
CHV

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nádory nervové tkáně

Neoplasms composed of nerve tissue. This concept does not refer to neoplasms located in the nervous system or its component nerves.
MSH

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amidy

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

organic compound derived from ammonia by substituting an acyl radical for hydrogen, or from an acid by replacing the OH group by NH2.
CSP

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vápníkové kanály

Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
MSH

voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions.
CSP

An ion channel with selective permeability to calcium.
NCI

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vodíkové ionty – koncentrace

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
MSH

Quantity of dimension one used to express on a scale from 0 to 14 the amount-of-substance concentration of hydrogen ion of dilute aqueous solution, calculated as the logarithm of the reciprocal of hydrogen-ion concentration in gram atoms per liter.
NCI

The log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
MSH

A measure of the acidity or alkalinity of a fluid on a scale of 0 to 14.
NCI

pH(1 mol/l)


HL7V3.0

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receptory muskarinové

One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3….) that are characterized by their cellular actions, pharmacology, and molecular biology.
MSH

G protein coupled surface receptor that mediates acetylcholine action on smooth and cardiac muscle and in CNS; may be linked to a potassium channel (membrane polarization) or second messenger systems.
CSP

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karotická endarterektomie

The excision of the thickened, atheromatous tunica intima of a carotid artery.
MSH

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nervová zakončení

Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
MSH

sensory receptors for afferent fibers, neuroeffectors for efferent fibers.
CSP

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. [GOC:dph, GOC:jl]
GO

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4-aminobutyráttransaminasa

An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.
MSH

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kostní svalek

The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing.
MSH

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hydroxylamin

organic compounds that contain the -NH2OH radical.
CSP

A colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.
MSH

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Proktalgie

Pain in the rectal area.
NCI

A disorder characterized by a sensation of marked discomfort in the rectal region.
NCI

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endoplazmatické retikulum

A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
MSH

system of cisternae in the cytoplasm of many cells; in places the endoplasmic reticulum is continuous with the plasma membrane or outer membrane of the nuclear envelope; rough endoplasmic reticulum membranes are coated with ribosomes and are involved in protein synthesis and transport; smooth endoplasmic reticulum is involved in steroid synthesis.
CSP

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

a part of the cell structure
CHV

The endoplasmic reticulum is a network of tubular membranes within the cytoplasm of the cell, occurring either with a smooth surface (smooth endoplasmic reticulum) or studded with ribosomes (rough endoplasmic reticulum), involved in the transport of materials. (Infoplease Dictionary)
NCI

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neurilemom

A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
MSH

A tumor of the peripheral nervous system that arises in the nerve sheath (protective covering). It is almost always benign, but rare malignant schwannomas have been reported.
NCI

a benign tumor that originates from the nervous system
CHV

A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of well differentiated Schwann cells. It recurs infrequently and only rare cases associated with malignant transformation have been reported.
NCI

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amoterapie

Treatment by application of hot sand.
MSH

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kandidóza

Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
MSH

infection with a fungus of the genus Candida; usually a superficial infection of the moist areas of the body and is generally caused by Candida albicans; includes chronic mucocutaneous candidiasis, cutaneous candidiasis, oral candidiasis (thrush), and monilial vaginitis.
CSP

A condition in which Candida albicans, a type of yeast, grows out of control in moist skin areas of the body. It is usually a result of a weakened immune system, but can be a side effect of chemotherapy or treatment with antibiotics. Thrush usually affects the mouth (oral thrush); however, rarely, it spreads throughout the entire body.
NCI

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hyperkalcémie

Abnormally high level of calcium in the blood.
MSH

abnormally high level of calcium in the blood; manifestations include fatigability, muscle weakness, depression, anorexia, nausea, and constipation.
CSP

Higher than normal levels of calcium in the blood. Some types of cancer increase the risk of hypercalcemia.
NCI

A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium in blood.
NCI

high level of calcium in the blood
CHV

Abnormally high concentration of calcium in the peripheral blood.
NCI

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Refsumova nemoc

An autosomal recessive familial disorder that usually presents in childhood with POLYNEUROPATHY; SENSORINEURAL HEARING LOSS; ICHTHYOSIS; ATAXIA; RETINITIS PIGMENTOSA; and CARDIOMYOPATHIES. (From Joynt, Clinical Neurology, 1991, Ch37, p58-9; Rev Med Interne 1996;17(5):391-8) This condition can be caused by mutation in the genes encoding peroxisomal phytanoyl-CoA hydroxylase or proteins associated peroxisomal membrane, leading to impaired catabolism of PHYTANIC ACID in PEROXISOMES.
MSH

autosomal recessive disorder of lipid metabolism in which deficiency of phytanic acid alpha-hydroxylase results in accumulation of phytanic acid; manifested chiefly by chronic polyneuritis, retinitis pigmentosa, cerebellar ataxia and elevation of protein in cerebrospinal fluid.
CSP

A rare autosomal recessive disorder characterized by abnormalities in the breakdown of phytanic acid and impaired growth of myelin sheaths. Signs and symptoms include neurologic damage, cerebellar degeneration, and neuropathy.
NCI

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koronavirus krocanů

A species of CORONAVIRUS causing enteritis in turkeys and pullets.
MSH

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