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dětská mortalita

Number of deaths of children between one year of age to 12 years of age in a given population.
MSH

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slitiny

A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions.
MSH

mixture of two or more metals or of one or more metals with certain metalloids that are mutually soluble in the molten condition; distinguished as binary, ternary, quaternary, etc., depending on the number of metals in the mixture.
CSP

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nos – obstrukce

Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.
MSH

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vztek

Fury; violent, intense anger.
MSH

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nemocnice vojenské

Hospitals which provide care for the military personnel and usually for their dependents.
MSH

A health care facility operated by the Department of Defense.


HL7V3.0

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Chlamydiales

An order of obligately intracellular, gram-negative bacteria that have the chlamydia-like developmental cycle of replication. This is a two-stage cycle that includes a metabolically inactive infectious form, and a vegetative form that replicates by binary fission. Members of Chlamydiales are disseminated by aerosol or by contact. There are at least six recognized families: CHLAMYDIACEAE, Criblamydiaceae, Parachlamydiaceae, Rhabdochlamydia, Simkaniaceae, and Waddliaceae.
MSH

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talasémie alfa

A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.
MSH

A genetic hematologic disorder characterized by partial or complete absence of the alpha globin chains of the heme molecule.
NCI

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utonutí neúplné

Non-fatal immersion or submersion in water. The subject is resuscitable.
MSH

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potkani – mutantní kmeny

Rats bearing mutant genes which are phenotypically expressed in the animals.
MSH

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Deltaretrovirus – infekce

Infections caused by the HTLV or BLV deltaretroviruses. They include human T-cell leukemia-lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED).
MSH

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fenylsulfonan chlorortuťnatý

A cytotoxic sulfhydryl reagent that inhibits several subcellular metabolic systems and is used as a tool in cellular physiology.
MSH

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Ambenonium

A bisquaternary ammonium alcohol with parasympathomimetic activity. The positive charge of ambenonium allows it to act as an acetylcholinesterase inhibitor by binding to the anionic site at the reactive center of acetylcholinesterase, preventing the breakdown of acetylcholine and producing an indirect cholinomimetic effect at both nicotinic and muscarinic receptors. Ambenonium also has direct agonist activity at nicotinic receptors, potentiating the cholinomimetic effect at the neuromuscular junction.
NCI

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zinostatin

An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
MSH

antitumor protein possessing a regulatory function on the metabolism of DNA; also a potent cytostatic agent active against gram-positive bacteria.
CSP

a kind of cancer treatment drug
CHV

An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39510&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39510&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C682″ NCI Thesaurus)
PDQ

An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04)
NCI

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receptory cholecystokininu

Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.
MSH

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hydantoiny

Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.
MSH

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cholekalciferol

Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
MSH

produced in human and other animal tissue by photoactivation (normally sunlight on skin) of 7-dehydrocholesterol.
CSP

A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption.
NCI

Vitamin D synthesized from ergosterol in yeast and plants.
NCI

A nutrient that the body needs in small amounts to function and stay healthy. Cholecalciferol helps the body use calcium and phosphorus to make strong bones and teeth. It is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, egg yolks, and dairy products. Skin exposed to sunshine can also make cholecalciferol. Not enough cholecalciferol can cause a bone disease called rickets. It is being studied in the prevention and treatment of some types of cancer.
NCI

A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39734&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39734&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48194″ NCI Thesaurus)
PDQ

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amidy

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

organic compound derived from ammonia by substituting an acyl radical for hydrogen, or from an acid by replacing the OH group by NH2.
CSP

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nádory nervové tkáně

Neoplasms composed of nerve tissue. This concept does not refer to neoplasms located in the nervous system or its component nerves.
MSH

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receptory muskarinové

One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3….) that are characterized by their cellular actions, pharmacology, and molecular biology.
MSH

G protein coupled surface receptor that mediates acetylcholine action on smooth and cardiac muscle and in CNS; may be linked to a potassium channel (membrane polarization) or second messenger systems.
CSP

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vodíkové ionty – koncentrace

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
MSH

Quantity of dimension one used to express on a scale from 0 to 14 the amount-of-substance concentration of hydrogen ion of dilute aqueous solution, calculated as the logarithm of the reciprocal of hydrogen-ion concentration in gram atoms per liter.
NCI

The log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
MSH

A measure of the acidity or alkalinity of a fluid on a scale of 0 to 14.
NCI

pH(1 mol/l)


HL7V3.0

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cholesteroloxidasa

An enzyme that catalyzes the oxidation of cholesterol in the presence of molecular oxygen to 4-cholesten-3-one and hydrogen peroxide. The enzyme is not specific for cholesterol, but will also oxidize other 3-hydroxysteroids. EC 1.1.3.6.
MSH

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4-aminobutyráttransaminasa

An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.
MSH

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nervová zakončení

Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
MSH

sensory receptors for afferent fibers, neuroeffectors for efferent fibers.
CSP

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. [GOC:dph, GOC:jl]
GO

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Proktalgie

Pain in the rectal area.
NCI

A disorder characterized by a sensation of marked discomfort in the rectal region.
NCI

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hydroxylamin

organic compounds that contain the -NH2OH radical.
CSP

A colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.
MSH

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chorioadenom

A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.
MSH

A type of cancer that grows into the muscular wall of the uterus. It is formed after conception (fertilization of an egg by a sperm). It may spread to other parts of the body, such as the vagina, vulva, and lung.
NCI

This term is used when a complete mole or very rarely a partial mole invades the myometrium. Microscopically, villi of hydatidiform mole are present within the myometrium or the myometrial vessels. Patients have persistent or rising hCG levels.
NCI

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amoterapie

Treatment by application of hot sand.
MSH

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neurilemom

A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
MSH

A tumor of the peripheral nervous system that arises in the nerve sheath (protective covering). It is almost always benign, but rare malignant schwannomas have been reported.
NCI

a benign tumor that originates from the nervous system
CHV

A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of well differentiated Schwann cells. It recurs infrequently and only rare cases associated with malignant transformation have been reported.
NCI

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Refsumova nemoc

An autosomal recessive familial disorder that usually presents in childhood with POLYNEUROPATHY; SENSORINEURAL HEARING LOSS; ICHTHYOSIS; ATAXIA; RETINITIS PIGMENTOSA; and CARDIOMYOPATHIES. (From Joynt, Clinical Neurology, 1991, Ch37, p58-9; Rev Med Interne 1996;17(5):391-8) This condition can be caused by mutation in the genes encoding peroxisomal phytanoyl-CoA hydroxylase or proteins associated peroxisomal membrane, leading to impaired catabolism of PHYTANIC ACID in PEROXISOMES.
MSH

autosomal recessive disorder of lipid metabolism in which deficiency of phytanic acid alpha-hydroxylase results in accumulation of phytanic acid; manifested chiefly by chronic polyneuritis, retinitis pigmentosa, cerebellar ataxia and elevation of protein in cerebrospinal fluid.
CSP

A rare autosomal recessive disorder characterized by abnormalities in the breakdown of phytanic acid and impaired growth of myelin sheaths. Signs and symptoms include neurologic damage, cerebellar degeneration, and neuropathy.
NCI

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hyperkalcémie

Abnormally high level of calcium in the blood.
MSH

abnormally high level of calcium in the blood; manifestations include fatigability, muscle weakness, depression, anorexia, nausea, and constipation.
CSP

Higher than normal levels of calcium in the blood. Some types of cancer increase the risk of hypercalcemia.
NCI

A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium in blood.
NCI

high level of calcium in the blood
CHV

Abnormally high concentration of calcium in the peripheral blood.
NCI

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