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hypobetalipoproteinémie

Conditions with abnormally low levels of BETA-LIPOPROTEINS (low density lipoproteins or LDL) in the blood. It is defined as LDL values equal to or less than the 5th percentile for the population. They include the autosomal dominant form involving mutation of the APOLIPOPROTEINS B gene, and the autosomal recessive form involving mutation of the microsomal triglyceride transfer protein. All are characterized by low LDL and dietary fat malabsorption.
MSH

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faktor aktivující trombocyty

A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
MSH

produced in response to specific stimuli by a variety of cell types, including neutrophils, basophils, platelets, and endothelial cells; several molecular species of platelet activating factor have been identified which vary in the length of the O-alkyl side chain; an important mediator of bronchoconstriction.
CSP

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léky – hodnocení

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
MSH

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blood flow measurement

techniques used to measure velocity and amount of blood flow and circulation in the living system.
CSP

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nikotinamidasa

An enzyme that catalyzes the hydrolysis of nicotinamide to nicotinate and ammonia. EC 3.5.1.19.
MSH

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T-lymfocyty

lymphocytes responsible for cell-mediated immunity, formed when lymphocytes circulate through the thymus gland and differentiate to thymocytes; when exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
CSP

Lymphocytes responsible for cell-mediated immunity. Two types have been identified – cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
MSH

A type of immune cell that can attack foreign cells, cancer cells, and cells infected with a virus. T lymphocytes can also help control immune responses. A T lymphocyte is a type of white blood cell.
NCI

A thymocyte-derived lymphocyte of immunological importance that is long-lived (months to years) and is responsible for cell-mediated immunity. T lymphocyte cells form rosettes with sheep erythrocytes and, in the presence of transforming agents (mitogens), differentiate and divide. These cells have the characteristic T3 surface marker and may be further divided into subsets according to function, such as helper, cytotoxic, etc.
NCI

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hypotalamus – nemoci

Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; AUTONOMIC NERVOUS SYSTEM DISEASES; SLEEP DISORDERS; behavioral symptoms related to dysfunction of the LIMBIC SYSTEM; and neuroendocrine disorders.
MSH

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Pleuronectus

Genus of Pleuronectidae including plaice and English sole.
MSH

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Duchenneova svalová dystrofie

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
MSH

An X-linked inherited disorder caused by mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.
NCI

a kind of inherited disorder, characterized by rapidly-worsening muscle weakness
CHV

X-linked recessive muscle disease caused by an inability to synthesize dystrophin, which is involved with maintaining the integrity of the sarcolemma; muscle fibers undergo a process that features degeneration and regeneration; clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy and an increased incidence of impaired mentation; Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course.
CSP

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krevní transfúze autologní

Reinfusion of blood or blood products derived from the patient`s own circulation. (Dorland, 27th ed)
MSH

reinfusion of blood or blood products derived from the patient`s own circulation.
CSP

Infusion of previously obtained autologous blood or blood products back to the same individual.
NCI

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nitrakrin

Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
MSH

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tandemové repetitivní sekvence

Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (INVERTED TANDEM REPEATS).
MSH

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ibuprofen

A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
MSH

nonsteroidal analgesic, antipyretic and anti-inflammatory agent that is a propionic acid derivative.
CSP

a chemical substance
CHV

A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
NCI

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C561″ NCI Thesaurus)
PDQ

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)
NCI

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podofylin

Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.
MSH

caustic extract from the roots of Podophyllum species; it contains podophyllotoxin and its congeners and is very irritating to mucous membranes and skin; it is a violent purgative that may cause CNS damage and teratogenesis; used as a paint for warts, skin neoplasms, and senile keratoses.
CSP

A resin extracted from the root of the plant Podophyllum sp. Berberidaceae (mandrake), which contains numerous compounds, among which podophyllotoxin is the principal active component. Podophyllin arrests mitosis in metaphase. Podophyllotoxin offers advantages over podophyllin in terms of purity, stability and lack of systemic toxicity. (NCI04)
NCI

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primární dysautonomie

An acute or chronic disorder, affecting the sympathetic or parasympathetic nervous system. It can be primary, the result of central nervous system degeneration, or secondary due to diabetes or alcoholism. Patients with the chronic form of this disorder usually have a progressive clinical course and a poor prognosis.
NCI

Disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a primary condition. Manifestations can involve any or all body systems but commonly affect the BLOOD PRESSURE and HEART RATE.
MSH

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tělo – velikost

The physical measurements of a body.
MSH

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nitrofenylgalaktosidy

Includes ortho-, meta-, and para-nitrophenylgalactosides.
MSH

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učební pomůcky

Instructional materials used in teaching.
MSH

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ileum

The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
MSH

distal part of the small intestine, extending from the jejunum to the cecum.
CSP

The final section of the small intestine. (NCI)
NCI

The final section of the small intestine.
NCI

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poly C

A group of cytosine ribonucleotides in which the phosphate residues of each cytosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

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bolest ucha

Pain in the ear.
MSH

A disorder characterized by a sensation of marked discomfort in the ear.
NCI

Painful sensation in the ear region.
NCI

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kosti – nádory

Tumors or cancer located in bone tissue or specific BONES.
MSH

new abnormal bone tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; includes tumors or cancer located in bone tissue or specific bones.
CSP

A benign or malignant (primary or metastatic) tumor involving the bone. Common malignant tumor types involving the bones are metastatic carcinomas and sarcomas. — 2003
NCI

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nonachlazin

Coronary vasodilator with a novel mechanism of action; proposed as antianginal agent.
MSH

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střídmost

Abstinence from alcohol.
MSH

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imunita aktivní

Resistance to a disease agent resulting from the production of specific antibodies by the host, either after exposure to the disease or after vaccination.
MSH

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kyselina polyglutamová

A peptide that is a homopolymer of glutamic acid.
MSH

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echovirus 9

A species of ENTEROVIRUS associated with outbreaks of aseptic meningitis (MENINGITIS, ASEPTIC).
MSH

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kyseliny polymethakrylové

Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.
MSH

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Economic

Used for the economic aspects of any subject, as well as for all aspects of financial management. It includes the raising or providing of funds.
MSH

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horečka boutonneuse

A febrile disease of the Mediterranean area, the Crimea, Africa, and India, caused by infection with RICKETTSIA CONORII.
MSH

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