Shopping Page. Buy or upgrade website.

chlorfenezin

A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)
MSH

Price: $1.00

Loading Updating cart…

Q-horečka

An acute infectious disease caused by COXIELLA BURNETII. It is characterized by a sudden onset of FEVER; HEADACHE; malaise; and weakness. In humans, it is commonly contracted by inhalation of infected dusts derived from infected domestic animals (ANIMALS, DOMESTIC).
MSH

acute infectious disease caused by Coxiella burnetii; characterized by a sudden onset of fever,headache, malaise, and weakness; in humans, it is commonly contracted by inhalation of infected dusts derived from infected domestic animals.
CSP

A bacterial infection caused by Coxiella burnetii. It is transmitted to humans by the inhalation of infected air particles or contact with fluids and feces of infected animals. Signs and symptoms include the abrupt onset of fever, headache, myalgias, and weakness.
NCI

Price: $1.00

Loading Updating cart…

leukémie bazofilní akutní

A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.
MSH

An acute myeloid leukemia in which the immature cells differentiate towards basophils. This is a rare leukemia. The observed cases have been associated with a poor prognosis. The term basophilic leukemia is used as a synonym for acute basophilic leukemia. Chronic basophilic leukemia is an inappropriate term vaguely connected to the term mast cell leukemia. (WHO, 2001)
NCI

Price: $1.00

Loading Updating cart…

flavoxát

A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.
MSH

A synthetic parasympatholytic with antimuscarinic, muscle relaxant and urinary antispasmodic properties. Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. In addition, this agent has been found to inhibit cyclic AMP formation in striatal membranes of the brain through stimulation of pertussis toxin-sensitive G protein-coupled receptors which in turn suppress isovolumetric urinary bladder contraction.
NCI

Price: $1.00

Loading Updating cart…

alanintransaminasa

An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
MSH

Expressed in liver, kidney, heart, fat, and skeletal muscle by glucocorticoid-induced human GPT Gene (Alanine Aminotransferase Family), 495-aa 54-kDa Glutamic-Pyruvate Transaminase is a homodimeric cytoplasmic pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. GPT mediates conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)
NCI

Price: $1.00

Loading Updating cart…

cholera – toxin

An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
MSH

enterotoxin from Vibrio cholerae that consists of two major protomers, the heavy (h) or a subunit and the b protomer which consists of 5 light (l) or b subunits.
CSP

Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia; A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04)
NCI

Price: $1.00

Loading Updating cart…

chinony

Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
MSH

benzene ring with 2 para keto groups.
CSP

A class of organic compounds with the base structure of quinone, an aromatic benzene molecule containing a double ketone functional group.
NCI

Price: $1.00

Loading Updating cart…

leukocytové kultury smíšené – test

Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
MSH

measure of histocompatibility at the HLA locus: peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days; lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not; in the one-way MLC test, the lymphocytes from one of the individuals are inactivated thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
CSP

Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (usually measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin C or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
NCI

Price: $1.00

Loading Updating cart…

fluoreny

A family of diphenylenemethane derivatives.
MSH

Price: $1.00

Loading Updating cart…

aldehyddehydrogenasa

An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
MSH

Price: $1.00

Loading Updating cart…

cholinesterasa – inhibitory

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
MSH

any substance or agent which suppresses, prevents or opposes the action of cholinesterase resulting in the potentiation of the action of endogenously released acetylcholine at cholinergic synapses; cholinesterase inhibition is associated with a variety of acute symptoms such as nausea, vomiting, blurred vision, stomach cramps, and rapid heart rate.
CSP

Price: $1.00

Loading Updating cart…

radikální krční disekce

A surgical procedure in which all the ipsilateral cervical lymph node groups of the neck, internal jugular vein, sternocleidomastoid muscle, spinal accessory nerve, and submandibular gland are removed.
NCI

A surgical operation for head and neck malignancies, most of which are squamous cell carcinomas. The neck is opened laterally, the majority of the sternocleidomastoid muscle is removed, as are the regional cervical lymph nodes, the jugular vein, the spinal accessory nerve, the submaxillary gland and most of the parotid gland. There are several modifications. (From Segen, Dictionary of Modern Medicine, 1992, p605)
MSH

Price: $1.00

Loading Updating cart…

luteinizační hormon

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
MSH

major gonadotropin secreted by the adenohypophysis; luteinizing hormone regulates steroid production by the interstitial cells of the gonads; the preovulatory luteinizing hormone surge in females induces ovulation and subsequent luteinization of the follicle.
CSP

a hormone that regulates steroid production by the TESTIS and the OVARY
CHV

Price: $1.00

Loading Updating cart…

flurbiprofen

An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
MSH

A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39245&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39245&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C508″ NCI Thesaurus)
PDQ

A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure.
NCI

Price: $1.00

Loading Updating cart…

alkylační látky

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
MSH

chemical agent that can add alkyl groups (for example, ethyl or methyl groups) to another molecule; many mutagens act through alkylation.
CSP

A type of drug that is used in the treatment of cancer. It interferes with the cell`s DNA and inhibits cancer cell growth.
NCI

Agents that replace hydrogen atom(s) in biologically active molecules with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cell growth.
NCI

Price: $1.00

Loading Updating cart…

choroidea – nemoci

Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.
MSH

Price: $1.00

Loading Updating cart…

hygiena záření

Health concerns associated with the effects of radiation on the environment and on public and personal health.
MSH

the health effects of radiation; includes effects and hazards from environmental radiation fallout, occupational radiation, diagnostic or therapeutic radiological equipment or materials.
CSP

Studies focusing on the effects of radiation on the environment and on public and personal health.
NCI

Price: $1.00

Loading Updating cart…

životní styl

Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)
MSH

typical way of life or manner of living characteristic of an individual or group.
CSP

A manner of living that reflects the person`s values and attitudes.
NCI

Price: $1.00

Loading Updating cart…

potraviny – kontrola

Examination of foods to assure wholesome and clean products free from unsafe microbes or chemical contamination, natural or added deleterious substances, and decomposition during production, processing, packaging, etc.
MSH

Price: $1.00

Loading Updating cart…

Alouatta

A genus of the subfamily ALOUATTINAE, family ATELIDAE, inhabiting the forests of Central and South America. Howlers travel in groups and define their territories by howling accompanied by vigorously shaking and breaking branches.
MSH

Price: $1.00

Loading Updating cart…

chrom – isotopy

Stable chromium atoms that have the same atomic number as the element chromium, but differ in atomic weight. Cr-50, 53, and 54 are stable chromium isotopes.
MSH

Price: $1.00

Loading Updating cart…

Ranidae

The family of true frogs of the order Anura. The family occurs worldwide except in Antarctica.
MSH

Price: $1.00

Loading Updating cart…

linuron

A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed)
MSH

Price: $1.00

Loading Updating cart…

předloktí

The structure on the upper limb, between the elbow and the wrist. (NCI)
NCI

The structure on the upper limb, between the elbow and the wrist.
NCI

Price: $1.00

Loading Updating cart…

alternativní lékařství

diagnostic or therapeutic technique which is presently outside the field of conventional medical practice; for use as a `tag` term index at `T` emphasis level.
CSP

Price: $1.00

Loading Updating cart…

chromozómy lidské, pár 15

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
MSH

The designation for each member of the fifteenth largest human autosomal chromosome pair. Chromosome 15 spans about 106 million base pairs and represents between 3 and 3.5% of the total DNA in normal diploid cells.
NCI

Price: $1.00

Loading Updating cart…

razoxan

An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex.
MSH

A bis-dioxopiperazine and a derivative of the chelating agent EDTA with antineoplastic activity. Razoxane inhibits the enzyme topoisomerase II without inducing DNA strand breaks, thereby inhibiting DNA synthesis and inducing cytotoxicity. Although its mechanism is unknown, this agent exhibits anti-angiogenic activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39480&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39480&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C801″ NCI Thesaurus)
PDQ

An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically inhibits the enzyme topoisomerase II without inducing DNA strand breaks, which may result in the inhibition of DNA synthesis and cell division in the premitotic and early mitotic phases of the cell cycle. This agent may also exhibit antiangiogenic and antimetastatic activities although the precise molecular mechanisms of these actions are unknown.
NCI

Price: $1.00

Loading Updating cart…

lipoproteiny HDL

A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
MSH

class of lipoproteins that promote transport of cholesterol from extrahepatic tissue to the liver for excretion in the bile; synthesized by the liver as particles lacking a lipid core, they accumulate a core of cholesterol esters during reverse cholesterol transport and transfer them to the liver directly or indirectly via other lipoprotein; HDL also shuttle apolipoproteins C-II and E to and from triglyceride-rich lipoproteins during catabolism of the lipoproteins; serum HDL cholesterol has been negatively correlated with premature coronary heart disease.
CSP

The smallest and densest lipoproteins, containing a high proportion of protein. They are synthesized in the liver as empty proteins and they pick up cholesterol and increase in size as they circulate through the bloodstream. Because HDL can remove cholesterol from the arteries, and transport it back to the liver for excretion, they are seen as “good” lipoproteins.
NCI

Price: $1.00

Loading Updating cart…

fosilní paliva

Any combustible hydrocarbon deposit formed from the remains of prehistoric organisms. Examples are petroleum, coal, and natural gas.
MSH

Price: $1.00

Loading Updating cart…

Ambystomatidae

A family of the class Urodela which includes 4 living genera, about 33 species, and occurs only in North America. Adults are usually terrestrial, but the larval forms are aquatic.
MSH

Price: $1.00

Loading Updating cart…

Comments are closed