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proteiny asociované v mikrotubulech

High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
MSH

fall into 2 general categories: large motor proteins (dynein, kinesin), and smaller tubulin-crosslinking proteins (tau proteins).
CSP

Proteins associated with the microtubule assembly infrastructure. These proteins include specialized motor proteins (dynein and kinesin) and smaller tubulin-crosslinking proteins (tau proteins). The proteins are required for both microtubule assembly and stabilization.
NCI

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pentosafosfátová dráha

pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final one being an oxidative decarboxylation to form a pentose phosphate.
CSP

The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”, MetaCyc:PENTOSE-P-PWY]
GO

An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
MSH

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vrozené srdeční vady

Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
MSH

A congenital heart defect is a problem with the structure of the heart. It is present at birth. Congenital heart defects are the most common type of major birth defect.

A baby`s heart begins to develop shortly after conception. During development, structural defects can occur. These defects can involve the walls of the heart, the valves of the heart and the arteries and veins near the heart. Congenital heart defects can disrupt the normal flow of blood through the heart. The blood flow can

  • Slow down
  • Go in the wrong direction or to the wrong place
  • Be blocked completely

Treatment for the defect can include medicines, surgery and other medical proceduresand heart transplants. The treatment depends on the type and severity of the defect and a child`s age, size and general health. Today, many children born with complex heart defects grow to adulthood and lead productive lives.

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

Imperfections or malformations of the heart, existing at birth
CHV

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emetika

Agents that cause vomiting. They may act directly on the gastrointestinal tract, bringing about emesis through local irritant effects, or indirectly, through their effects on the chemoreceptor trigger zone in the postremal area near the medulla.
MSH

class of agents that cause vomiting; may act directly on the gastrointestinal tract, bringing about emesis through local irritant effects, or indirectly, through their effects on the chemoreceptor trigger zone in the postremal area near the medulla.
CSP

Describes a substance that causes vomiting.
NCI

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kadaverin

A foul-smelling diamine formed by bacterial decarboxylation of lysine.
MSH

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spermové banky

Centers for acquiring and storing semen.
MSH

Freezing sperm for use in the future. This procedure can allow men to father children after loss of fertility.
NCI

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minerální olej

A mixture of liquid hydrocarbons obtained from petroleum. It is used as laxative, lubricant, ointment base, and emollient.
MSH

A type of oil that is made from petroleum (mixture of oily liquids found in the earth). Mineral oil is used in laxatives, lubricants, creams, and lotions.
NCI

A mixture of liquid paraffinic, naphthenic and polycyclic aromatic hydrocarbons obtained from petroleum in which the amount and types of aromatic hydrocarbons is dependent on the treatment process. Untreated and mildly treated mineral oils contain the highest amount of aromatic and unsaturated compounds and are primarily used as a lubricant base oil to produce further refined oil products. Exposure to these types of mineral oils can cause rapid respiration, cyanosis, tachycardia and low-grade fever. Untreated and mildly treated mineral oils are strongly associated with an increased risk of scrotal and skin cancer but can also cause gastrointestinal, rectal, bladder and certain respiratory-tract cancers. (NCI05)
NCI

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Peptococcus

A genus of gram-positive, anaerobic, coccoid bacteria that is part of the normal flora of the mouth, upper respiratory tract, and large intestine in humans. Its organisms cause infections of soft tissues and bacteremias.
MSH

A genus of anaerobic, Gram positive, cocci shaped bacterium assigned to the phylum Firmicutes and the family Peptococcaceae.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Peptococcus genus level.
NCI

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termogeneze

heat production in the body by muscular activity (e.g. shivering), food intake, or increased metabolic rate, frequently hormonally regulated.
CSP

The generation of heat in order to maintain body temperature. The uncoupled oxidation of fatty acids contained within brown adipose tissue and SHIVERING are examples of thermogenesis in MAMMALS.
MSH

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viry encefalitidy klíšťové

A subgroup of the genus FLAVIVIRUS that causes encephalitis and hemorrhagic fevers and is found in eastern and western Europe and the former Soviet Union. It is transmitted by TICKS and there is an associated milk-borne transmission from viremic cattle, goats, and sheep.
MSH

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pantothenát vápenatý

The calcium salt of the water-soluble vitamin B5, ubiquitously found in plants and animal tissues with antioxidant property. Pentothenate is a component of coenzyme A (CoA) and a part of the vitamin B2 complex. Vitamin B5 is a growth factor and is essential for various metabolic functions, including the metabolism of carbohydrates, proteins, and fatty acids. This vitamin is also involved in the synthesis of cholesterol, lipids, neurotransmitters, steroid hormones, and hemoglobin.
NCI

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sfinkterotomie transhepatická

Surgery of the smooth muscle sphincter of the hepatopancreatic ampulla to relieve blocked biliary or pancreatic ducts.
MSH

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mitobronitol

Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent.
MSH

A brominated analog of mannitol with potential antineoplastic activity. Mitobronitol most likely acts through alkylation via derived epoxide groups.
NCI

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perikarditida konstriktivní

Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.
MSH

A heart disorder in which the pericardial sac becomes thickened and fibrotic, tightening the myocardium and impeding the normal myocardial function.
NCI

A disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action.
NCI

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hemaglutininy virové

Specific hemagglutinin subtypes encoded by VIRUSES.
MSH

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endokrinní žlázy

Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.
MSH

Ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
NCI

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calusterone

A 17-alkylated orally active androgenic steroid. Calusterone may alter the metabolism of estradiol and reduce estrogen production. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41710&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41710&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C337″ NCI Thesaurus)
PDQ

A 17-alkylated orally active androgenic steroid. Calusterone may alter the metabolism of estradiol and reduce estrogen production. (NCI04)
NCI

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spiramycin

A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.
MSH

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modely molekulární

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
NCI

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periflebitida

Periphlebitis is inflammation of the outer coat of a vein or of tissues surrounding the vein.
MSH

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hemerythrin

A non-heme iron protein consisting of eight apparently identical subunits each containing 2 iron atoms. It binds one molecule of oxygen per pair of iron atoms and functions as a respiratory protein.
MSH

protein found in the blood of earthworms which imparts its red color.
CSP

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endotoxiny

Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
MSH

toxin closely associated with the living cytoplasm or cell wall of certain microorganisms, which does not readily diffuse into the culture medium, but is released upon lysis of the cells.
CSP

The lipopolysaccharide complexes that are part of the outer membrane of the cell wall of Gram-negative bacteria such as E. coli, Salmonella, Shigella, Pseudomonas, Neisseria, Haemophilus, and other leading pathogens. Upon bacterial infections, the lipid component (Lipid A) of endotoxin contributes to its toxicity, while the polysaccharide components contribute to immunogenicity.
NCI

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kanrenoát draselný

A synthetic pregnadiene derivative with anti-aldosterone activity.
MSH

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spondylóza

A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.
MSH

degeneration of the spinal bone where spinal columns are fused and immobilized
CHV

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monensin

An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts` development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.
MSH

polyether ionophore produced by Streptomyces cinnamonensis; causes collapse of sodium and potassium gradients at the plasma membrane, blocks intracelluar protein transport, and has broad antimicrobial efficacy; also has vasodilatory-antihypertensive properties.
CSP

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osobnostní dotazník

Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.
MSH

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hemoglobinopatie

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
MSH

group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
CSP

An inherited disorder characterized by structural alterations of a globin chain within the hemoglobin molecule.
NCI

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enteropeptidasa

A specialized proteolytic enzyme secreted by intestinal cells. It converts TRYPSINOGEN into its active form TRYPSIN by removing the N-terminal peptide. EC 3.4.21.9.
MSH

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karbamoylfosfátsynthasa (hydrolyzující glutamin)

An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
MSH

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stapes

One of the three ossicles of the middle ear. It transmits sound vibrations from the INCUS to the internal ear (Ear, Internal see LABYRINTH).
MSH

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