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karbamoylfosfátsynthasa (hydrolyzující glutamin)

An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
MSH

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alternativní lékařství

diagnostic or therapeutic technique which is presently outside the field of conventional medical practice; for use as a `tag` term index at `T` emphasis level.
CSP

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proteiny asociované v mikrotubulech

High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
MSH

fall into 2 general categories: large motor proteins (dynein, kinesin), and smaller tubulin-crosslinking proteins (tau proteins).
CSP

Proteins associated with the microtubule assembly infrastructure. These proteins include specialized motor proteins (dynein and kinesin) and smaller tubulin-crosslinking proteins (tau proteins). The proteins are required for both microtubule assembly and stabilization.
NCI

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razoxan

An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex.
MSH

A bis-dioxopiperazine and a derivative of the chelating agent EDTA with antineoplastic activity. Razoxane inhibits the enzyme topoisomerase II without inducing DNA strand breaks, thereby inhibiting DNA synthesis and inducing cytotoxicity. Although its mechanism is unknown, this agent exhibits anti-angiogenic activity. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39480&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39480&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C801″ NCI Thesaurus)
PDQ

An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically inhibits the enzyme topoisomerase II without inducing DNA strand breaks, which may result in the inhibition of DNA synthesis and cell division in the premitotic and early mitotic phases of the cell cycle. This agent may also exhibit antiangiogenic and antimetastatic activities although the precise molecular mechanisms of these actions are unknown.
NCI

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vrozené srdeční vady

Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
MSH

A congenital heart defect is a problem with the structure of the heart. It is present at birth. Congenital heart defects are the most common type of major birth defect.

A baby`s heart begins to develop shortly after conception. During development, structural defects can occur. These defects can involve the walls of the heart, the valves of the heart and the arteries and veins near the heart. Congenital heart defects can disrupt the normal flow of blood through the heart. The blood flow can

  • Slow down
  • Go in the wrong direction or to the wrong place
  • Be blocked completely

Treatment for the defect can include medicines, surgery and other medical proceduresand heart transplants. The treatment depends on the type and severity of the defect and a child`s age, size and general health. Today, many children born with complex heart defects grow to adulthood and lead productive lives.

NIH: National Heart, Lung, and Blood Institute


MEDLINEPLUS

Imperfections or malformations of the heart, existing at birth
CHV

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karboanhydrasa III

A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL). EC 4.2.1.-
MSH

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Ambystomatidae

A family of the class Urodela which includes 4 living genera, about 33 species, and occurs only in North America. Adults are usually terrestrial, but the larval forms are aquatic.
MSH

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minerální olej

A mixture of liquid hydrocarbons obtained from petroleum. It is used as laxative, lubricant, ointment base, and emollient.
MSH

A type of oil that is made from petroleum (mixture of oily liquids found in the earth). Mineral oil is used in laxatives, lubricants, creams, and lotions.
NCI

A mixture of liquid paraffinic, naphthenic and polycyclic aromatic hydrocarbons obtained from petroleum in which the amount and types of aromatic hydrocarbons is dependent on the treatment process. Untreated and mildly treated mineral oils contain the highest amount of aromatic and unsaturated compounds and are primarily used as a lubricant base oil to produce further refined oil products. Exposure to these types of mineral oils can cause rapid respiration, cyanosis, tachycardia and low-grade fever. Untreated and mildly treated mineral oils are strongly associated with an increased risk of scrotal and skin cancer but can also cause gastrointestinal, rectal, bladder and certain respiratory-tract cancers. (NCI05)
NCI

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receptor epidermálního růstového faktoru

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
MSH

Epidermal growth factor receptor (1210 aa, 134 kD) is a cell adhesion process protein that is encoded by the human EGFR gene and has roles in cell-cell adhesion, cell migration, cell proliferation and signal transduction.
NCI

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termogeneze

heat production in the body by muscular activity (e.g. shivering), food intake, or increased metabolic rate, frequently hormonally regulated.
CSP

The generation of heat in order to maintain body temperature. The uncoupled oxidation of fatty acids contained within brown adipose tissue and SHIVERING are examples of thermogenesis in MAMMALS.
MSH

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karcinom bazoskvamózní

A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
MSH

skin carcinoma that histologically exhibits both basal and squamous elements.
CSP

A basal cell carcinoma which displays squamous differentiation. The neoplastic cells have more abundant cytoplasm with more marked keratinization than typical basal cell carcinomas. It usually has a more aggressive clinical course compared to typical basal cell carcinoma, and it may produce regional or widespread metastases.
NCI

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Activation of Amino Acids

The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. [GOC:jl]
GO

A reaction that produces an “activated” amino acid derivative, such as amino acyl adenylate, or amino acylphosphorylate and provides energy for the amino acid to be incorporated into a peptide, protein, or other macromolecule.
MSH

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mitobronitol

Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent.
MSH

A brominated analog of mannitol with potential antineoplastic activity. Mitobronitol most likely acts through alkylation via derived epoxide groups.
NCI

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receptory steroidů

Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
MSH

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hemaglutininy virové

Specific hemagglutinin subtypes encoded by VIRUSES.
MSH

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kardiopulmonální bypass

Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
MSH

A procedure to circulate and oxygenate the blood by a machine during heart surgery
CHV

diversion of the blood flow to the heart directly to the aorta, via a pump oxygenator, avoiding the heart and/or the lungs; a form of extracorporeal circulation used in heart surgery; see BLOOD OXYGENATOR for the portion that oxygenates the blood and EXTRACORPOREAL CIRCULATION for the portion that recirculates one`s blood.
CSP

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5-aminolevulátsynthetasa

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
MSH

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modely molekulární

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
NCI

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referenční knihy

Books designed by the arrangement and treatment of their subject matter to be consulted for definite terms of information rather than to be read consecutively. Reference books include DICTIONARIES; ENCYCLOPEDIAS; ATLASES; etc. (From the ALA Glossary of Library and Information Science, 1983)
MSH

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hemerythrin

A non-heme iron protein consisting of eight apparently identical subunits each containing 2 iron atoms. It binds one molecule of oxygen per pair of iron atoms and functions as a respiratory protein.
MSH

protein found in the blood of earthworms which imparts its red color.
CSP

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arteria carotis – stenóza

Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp822-3)
MSH

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amoxapin

The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both. It also blocks dopamine receptors.
MSH

A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.
NCI

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monensin

An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts` development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.
MSH

polyether ionophore produced by Streptomyces cinnamonensis; causes collapse of sodium and potassium gradients at the plasma membrane, blocks intracelluar protein transport, and has broad antimicrobial efficacy; also has vasodilatory-antihypertensive properties.
CSP

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regulační sekvence nukleových kyselin

Nucleic acid sequences involved in regulating the expression of genes.
MSH

binding sites on DNA for proteins that control genetic events; compare with STRUCTURAL GENE and REGULATORY GENE.
CSP

Any DNA sequence involved in the regulation of genetic processes such as transcription and replication.
NCI

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hemoglobinopatie

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
MSH

group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
CSP

An inherited disorder characterized by structural alterations of a globin chain within the hemoglobin molecule.
NCI

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extrakce katarakty

The removal of a cataractous CRYSTALLINE LENS from the eye.
MSH

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amylosa

An unbranched glucan in starch.
MSH

A starch consisting of exclusively alpha-D glucose monomers connected by a 1-4 bond.
NCI

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morálka – vývoj

The process by which individuals internalize standards of right and wrong conduct.
MSH

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doučování

Specialized instruction for students deviating from the expected norm.
MSH

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hemostáza

The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
MSH

process of arresting blood flow or bleeding, either physiologically by vasoconstriction and coagulation or by mechanical or surgical means.
CSP

The arrest of bleeding, either by the natural processes of vasoconstriction and coagulation or by surgical means.
NCI

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. [ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

The arrest of bleeding, either by the physiological properties of vasoconstriction and coagulation or by surgical means.
NCI

body function that stops bleeding by coagulating blood and constricting blood vessel
CHV

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