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Human Genetics

The branch of genetics focusing on human heredity.
NCI

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karboanhydrasa III

A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL). EC 4.2.1.-
MSH

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riboflavin

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
MSH

water soluble B vitamin; precursor of FMN and FAD.
CSP

Water-soluble vitamin that is a coenzyme in numerous oxidation-reduction reactions. (DRI)
NCI

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Riboflavin helps make red blood cells, helps some enzymes work properly, and keeps skin, nails, and hair healthy. It is found in milk, eggs, malted barley, organ meats, yeast, and leafy vegetables. Riboflavin is water-soluble (can dissolve in water) and must be taken in every day. Not enough riboflavin can cause anemia (a low number of red blood cells), mouth sores, and skin problems. Amounts of riboflavin may be higher in the blood of patients with some types of cancer.
NCI

An essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38330&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38330&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C808″ NCI Thesaurus)
PDQ

An essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair.
NCI

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nádorové cirkulující buňky

exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors.
CSP

A metastatic cancer cell found in the peripheral blood.
NCI

Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors.
MSH

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uhlovodíky

organic compound that contains carbon and hydrogen only.
CSP

A substance made of only hydrogen and carbon. Examples of hydrocarbons are coal, petroleum, natural gas and tar. They are used as energy sources. Being exposed to hydrocarbons may increase the risk of certain types of cancer.
NCI

A group of organic compounds that consist of only hydrogen (H) and carbon (C) atoms and are involved in energy production. They may be cyclic or non-cyclic compounds. They may have double bonds, single bonds or both with carbon forming the backbone.
NCI

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karcinom bazoskvamózní

A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
MSH

skin carcinoma that histologically exhibits both basal and squamous elements.
CSP

A basal cell carcinoma which displays squamous differentiation. The neoplastic cells have more abundant cytoplasm with more marked keratinization than typical basal cell carcinomas. It usually has a more aggressive clinical course compared to typical basal cell carcinoma, and it may produce regional or widespread metastases.
NCI

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Rickettsiaceae

A family of small, gram-negative organisms, often parasitic in humans and other animals, causing diseases that may be transmitted by invertebrate vectors.
MSH

A taxonomic family of Gram negative, non acid fast bacterium in the phylum Proteobacteria that includes the genera Rickettsia and Wolbachia, among others.
NCI

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Nepál

A country in Southern Asia, between China and India. (NCI)
NCI

A country in Southern Asia, between China and India. (CIA World Factbook 2002)
NCI

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jaderná fúze

Thermonuclear reaction in which the nuclei of an element of low atomic weight unite under extremely high temperature and pressure to form a nucleus of a heavier atom.
MSH

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hydrostatický tlak

The pressure due to the weight of fluid.
MSH

pressure at any level on a fluid at rest due the weight of the fluid above it.
CSP

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kardiopulmonální bypass

Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
MSH

A procedure to circulate and oxygenate the blood by a machine during heart surgery
CHV

diversion of the blood flow to the heart directly to the aorta, via a pump oxygenator, avoiding the heart and/or the lungs; a form of extracorporeal circulation used in heart surgery; see BLOOD OXYGENATOR for the portion that oxygenates the blood and EXTRACORPOREAL CIRCULATION for the portion that recirculates one`s blood.
CSP

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DNA řízené RNA-polymerasy

Enzymes that catalyze DNA template-directed extension of the 3`-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
MSH

RNA polymerases comprise a group of enzymes that catalyze extension, one nucleotide at a time, of the 3 prime-end of an RNA strand along a complementary DNA template.
NCI

Enzymes that catalyze the template-directed stepwise addition of ribonucleotides to the 3` end of a growing RNA chain using a single-stranded DNA template. The reaction is important in the flow of information from DNA to proteins. Three different forms of the polymerase have been identified and characterized.
NCI

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nervový systém – nádory

Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
MSH

benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges; included are primary and metastatic nervous system neoplasms.
CSP

A benign or malignant, primary or metastatic neoplasm involving the central or peripheral nervous system.
NCI

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nukleotidy – mapování

Two-dimensional separation and analysis of nucleotides.
MSH

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hydroxyprostaglandindehydrogenasy

Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.
MSH

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arteria carotis – stenóza

Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp822-3)
MSH

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RNA transferová Gly

A transfer RNA which is specific for carrying glycine to sites on the ribosomes in preparation for protein synthesis.
MSH

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neurofibrily

The delicate interlacing threads, formed by aggregations of neurofilaments and neurotubules, coursing through the cytoplasm of the body of a neuron and extending from one dendrite into another or into the axon.
MSH

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ošetřovatelský výzkum

research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.
CSP

Clinical research carried out by nurses.
NCI

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hyperglykemické hyperosmolární neketotické kóma

A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.
MSH

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extrakce katarakty

The removal of a cataractous CRYSTALLINE LENS from the eye.
MSH

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rooming-in

Care of the newborn infant in a crib near the mother`s bed, instead of in a nursery, during the hospital stay.
MSH

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neurofarmakologie

The branch of pharmacology dealing especially with the action of drugs upon various parts of the nervous system.
MSH

study of the origin, nature, properties, and actions of drugs and their effects on the nervous system; use this term mainly for intended, desired effects; for harmful or undesired effects, see NEUROTOXICOLOGY.
CSP

A branch of pharmacology concerned with the effects of drugs on the nervous system.
NCI

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obidoxim

Cholinesterase reactivator occurring in two interchangeable isomeric forms, syn and anti.
MSH

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hypertenze maligní

A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
MSH

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Caucasoid Race

Denotes a person with European, Middle Eastern, or North African ancestral origin who identifies, or is identified, as White. Reference: FDA Guidance on Race & Ethnicity ( http://www.fda.gov/cder/guidance/5656fnl.htm )
NCI

A person having origins in any of the original peoples of Europe, the Middle East, or North Africa.
NCI

Denotes person with European, Middle Eastern, or North African ancestral origin who identifies, or is identified, as White.
NCI

A group distinguished by classification according to physical features. This group, also called Europoid, centers around the Mediterranean Sea but includes other parts of Europe. (from Winick: Dictionary of Anthropology, 1972; American Heritage Dictionary, 2d College ed)
MSH

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bachor

The first stomach of ruminants. It lies on the left side of the body, occupying the whole of the left side of the abdomen and even stretching across the median plane of the body to the right side. It is capacious, divided into an upper and a lower sac, each of which has a blind sac at its posterior extremity. The rumen is lined by mucous membrane containing no digestive glands, but mucus-secreting glands are present in large numbers. Coarse, partially chewed food is stored and churned in the rumen until the animal finds circumstances convenient for rumination. When this occurs, little balls of food are regurgitated through the esophagus into the mouth, and are subjected to a second more thorough mastication, swallowed, and passed on into other parts of the compound stomach. (From Black`s Veterinary Dictionary, 17th ed)
MSH

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Nová Guinea

Originally an island of the Malay Archipelago, the second largest island in the world. It divided, West New Guinea becoming part of Indonesia and East New Guinea becoming Papua New Guinea.
MSH

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oktreotid

A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
MSH

potent, long-acting synthetic somatostatin octapeptide analog.
CSP

A drug similar to the naturally occurring growth hormone inhibitor somatostatin. Octreotide is used to treat diarrhea and flushing associated with certain types of tumors.
NCI

A synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone.
NCI

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hypoglyciny

Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH.
MSH

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