An enzyme that specifically cleaves the ester sulfate of iduronic acid. Its deficiency has been demonstrated in Hunter`s syndrome, which is characterized by an excess of dermatan sulfate and heparan sulfate. EC 22.214.171.124.
Iduronate 2-sulfatase (550 aa, ~62 kDa) is encoded by the human IDS gene. This protein is involved in the degradation of glycosaminoglycans.