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lysogenie

The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.
MSH

phenomenon by which a temperate phage integrates itself into the DNA of a bacterial host, establishing a type of symbiotic relation between prophage and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium; upon induction by various agents, such as chemicals or ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.
CSP

The incorporation of a bacteriophage genome into the genome of its bacterial host organism. [ISBN:0781702534]
GO

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1-acylglycerofosfocholin-O-acyltransferasa

An enzyme localized predominantly within the plasma membrane of lymphocytes. It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. EC 2.3.1.23.
MSH

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lysofosfatidylcholiny

derivatives of phosphatidylcholines obtained by their partial hydrolysis which removes one of the fatty acid moieties.
CSP

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lysofosfolipasa

An enzyme that catalyzes the hydrolysis of a single fatty acid ester bond in lysoglycerophosphatidates with the formation of glyceryl phosphatidates and a fatty acid. EC 3.1.1.5.
MSH

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lysofosfolipidy

Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.
MSH

phospholipid that lacks one of its fatty acyl chains; an intermediate formed during digestion of dietary and biliary phospholipids.
CSP

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lyzozómy

A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
MSH

morphologically heterogeneous cytoplasmic particles characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes, normally involved in the process of localized intracellular digestion; the activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured.
CSP

A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed.
NCI

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

A class of morphologically heterogeneous cytoplasmic membrane-bound vesicle in animal and plant tissues characterized by their content of a wide variety of glycoprotein hydrolytic enzymes active at an acid pH and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells and is supposed to be under metabolic (hormonal) control.
NCI

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lysostafin

A 25-kDa peptidase produced by Staphylococcus simulans which cleaves a glycine-glcyine bond unique to an inter-peptide cross-bridge of the STAPHYLOCOCCUS AUREUS cell wall. EC 3.4.24.75.
MSH

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lysyloxidasa

An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.
MSH

Lysyl oxidase; a copper-dependent enzyme that initiates the crosslinking of collagens and elastin, oxidizes lysine residues to alpha-aminoadipic-delta-semialdehyde. (LocusLink)
NCI

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lysin-tRNA-ligasa

An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6.
MSH

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Macaca

large genus of Old World monkeys (family Cercopithecidae) that includes the macaque and rhesus monkeys, and the Barbary apes; Macaca mulatta, the rhesus monkey, is used as a research animal.
CSP

A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of 16 species inhabiting forests of Africa, Asia, and the islands of Borneo, Philippines, and Celebes.
MSH

Any of several species of short-tailed monkeys of the genus Macacus.
NCI

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Macaca fascicularis

found in most of Southeast Asia; long tailed; used in research instead of rhesus.
CSP

A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.
MSH

A macaque, Macaca fascicularis (M. cynomolgus), found mostly in southeastern Asia, Borneo, and the Philippines.
NCI

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Macaca mulatta

species of the genus MACACA inhabiting India, China, and other parts of Asia; the species is used extensively in biomedical research and adapts very well to living with humans.
CSP

A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.
MSH

A pale brown macaque (Macaca mulatta) native to India, China, and other parts of Asia; often used in medical research. A medium-sized diurnal primate, the Macaca mulatta has a diet of plant material and insects that it can store in pouches in its mouth. The rhesus monkey has an inquisitive, destructive nature with a tendency to bite and pinch; captive breeds are used almost exclusively for medical research. The rhesus monkey has a long history in biomedical research owing to its relative ease in upkeep, most famously utilized in the study of the rhesus factor in human blood groups, the effects of space travel on humans, as well as being the first cloned and transgenic primate.
NCI

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Macaca nemestrina

found in Southeast Asia, Sumatra and Borneo; medium length tail carried arched over back, crown hairs form horse-shoe shaped patch, females conspicuous purple-pink sexual swelling at estrus.
CSP

A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.
MSH

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Macaca radiata

A species of macaque monkey that mainly inhabits the forest of southern India. They are also called bonnet macaques or bonnet monkeys.
MSH

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Macao

A country in Eastern Asia, bordering the South China Sea and China. (CIA World Factbook 2002)
NCI

A country in Eastern Asia, bordering the South China Sea and China. (NCI)
NCI

Special Administrative Region of the People`s Republic of China since December 20, 1999 with its own constitution. The island of Macau and adjacent islands are located off the southeast coast of China.
MSH

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Machado-Joseph nemoc

A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
MSH

A very rare, autosomal dominant inherited neurodegenerative disorder. Signs and symptoms include ataxia, spasticity, and abnormalities in the ocular movements.
NCI

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machiavelismus

A personality dimension characterized by the manipulation of others.
MSH

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Waldenströmova makroglobulinémie

A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.
MSH

plasma cell dyscrasia resembling leukemia, with cells of lymphocytic, plasmacytic, or intermediate morphology, that secrete an IgM monoclonal component.
CSP

An indolent (slow-growing) type of non-Hodgkin lymphoma marked by abnormal levels of IgM antibodies in the blood and an enlarged liver, spleen, or lymph nodes.
NCI

Lymphoplasmacytic lymphoma associated with bone marrow involvement and IgM monoclonal gammopathy.
NCI

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makroglobuliny

Serum globulins with high molecular weight. (Dorland, 28th ed)
MSH

serum globulins with high molecular weight.
CSP

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makroglosie

The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)
MSH

A finding indicating enlargement of the tongue.
NCI

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makrofágy – aktivace

The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.
MSH

A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149 “Fundamental Immunology”, PMID:14506301]
GO

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makrofágy – faktory inhibice migrace

Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.
MSH

protein factors released by sensitized lymphocytes (and possibly other cells) that inhibit the movement of macrophages and leukocytes away from their site of release.
CSP

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makrofágy

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
MSH

mononuclear phagocytes found in tissue.
CSP

A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.
NCI

a kind of white blood cell
CHV

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makrostomie

Greatly exaggerated width of the mouth, resulting from failure of union of the maxillary and mandibular processes, with extension of the oral orifice toward the ear. The defect may be unilateral or bilateral. (Dorland, 27th ed)
MSH

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makuly akustické

The sensory areas on the vertical wall of the saccule and in the floor of the utricle. The hair cells in the maculae are innervated by fibers of the VESTIBULAR NERVE.
MSH

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ORBAINAREN ENDAKATZEA

deterioration of the macula lutea in the retina; may be inherited, drug induced, or due to aging; leads to a severe loss of central vision while peripheral vision is retained.
CSP

Macular degeneration, or age-related macular degeneration (AMD) is a leading cause of vision loss in Americans 60 and older. It is a disease that destroys your sharp, central vision. You need central vision to see objects clearly and to do tasks such as reading and driving.

AMD affects the macula, the part of the eye that allows you to see fine detail. It does not hurt, but it causes cells in the macula to die. In some cases, AMD advances so slowly that people notice little change in their vision. In others, the disease progresses faster and may lead to a loss of vision in both eyes. Regular comprehensive eye exams can detect macular degeneration before the disease causes vision loss. Treatment can slow vision loss. It does not restore vision.

NIH: National Eye Institute


MEDLINEPLUS

deterioration of the eye part called macula lutea of the retina
CHV

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makulární edém cystoidní

Fluid accumulation in the outer layer of the MACULA LUTEA at the center of the RETINA in a petaloid pattern where cystic spaces are formed and may lead to macular depressions or holes.
MSH

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Madagaskar

One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster`s New Geographical Dictionary, 1988, p714)
MSH

A country in Southern Africa, occupying an island in the Indian Ocean, east of Mozambique. (NCI)
NCI

A country in Southern Africa, occupying an island in the Indian Ocean, east of Mozambique. (CIA World Factbook 2002)
NCI

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Lipomatosis, Familial Benign Cervical

Diffuse lipomatosis of the neck. It is also known as fat neck or horsecollar lipomata.
MSH

A neoplastic process characterized by a symmetric poorly circumscribed overgrowth of adipose tissue in the neck. It predominantly affects middle age men of Mediterranean origin.
NCI

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Madurella

A mitosporic fungal genus that causes MYCETOMA in humans. Madurella grisea and M. mycetomatis are the etiological agents.
MSH

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