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N-acetyllaktosaminsynthetasa

The A protein of the lactose synthase complex. In the presence of the B protein (LACTALBUMIN) specificity is changed from N-acetylglucosamine to glucose. EC 2.4.1.90.
MSH

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N-acetylmuramoyl-L-alaninamidasa

An autolytic enzyme bound to the surface of bacterial cell walls. It catalyzes the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell wall glycopeptides, particularly peptidoglycan. EC 3.5.1.28.
MSH

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N-Cadherins

Human Neural-cadherin is encoded by the CDH2 gene. The gene product is 906 amino acids and ~100kD in size. This protein plays a role in calcium-dependent cell adhesion.
NCI

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N-formylmethionin

Effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well as in the mitochondria of eucaryotic cells.
MSH

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N-formylmethionin-leucyl-fenylalanin

N-Formylmethionyl-leucyl-phenylalanine. A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.
MSH

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ipratropium

A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.
MSH

A synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic postganglionic effector cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine (Ach) mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation.
NCI

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N-nitrosopyrrolidin

Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism.
MSH

A clear, yellow, oily, liquid nitrosamine that decomposes when exposed to light and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosopyrrolidine is used in laboratory research to induce tumors in experimental animals. This substance may be formed during cooking of foods that contain sodium nitrite as a preservative, including meat, fish and cheese. Exposure to N- Nitrosopyrrolidine irritates the skin and eyes and can damage the liver and kidneys. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
NCI

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N-ras Genes

Human Oncogene N-RAS is a mutated variant of NRAS Gene (RAS Family), which encodes p21 N-Ras Protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. RAS is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, specific amino acid mutations activate c-RAS and transform cells. Oncogene NRAS disrupts normal cell function.
NCI

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NAD

A coenzyme composed of ribosylnicotinamide 5`-diphosphate coupled to adenosine 5`-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
MSH

coenzyme composed of ribosylnicotinamide 5`-diphosphate coupled to adenosine 5`-phosphate by pyrophosphate linkage; found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).
CSP

Nicotinamide Adenine Dinucleotide, a coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions and the production of energy through redox reactions.
NCI

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NAD+ nukleosidasa

An enzyme that catalyzes the hydrolysis of nicotinamide adenine dinucleotide (NAD) to NICOTINAMIDE and ADENOSINE DIPHOSPHATE RIBOSE. Some are extracellular (ectoenzymes).The enzyme from some sources also catalyses the hydrolysis of nicotinamide adenine dinucleotide phosphate (NADP).
MSH

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NAD(P)H dehydrogenasa (chinon)

A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
MSH

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NAD(P)(+)-Arginine ADP-Ribosyltransferase

An enzyme that catalyzes the transfer of the ADP-ribose moiety from NAD+ or NADP+ to specific protein substrates with arginine, arginine-type compounds, agmatine, or guanidine as acceptors. This mono-ADP-ribosylation reaction is the mechanism of action common to several bacterial toxins affecting profound changes in cellular metabolism, such as activation of adenylate cyclase, regulation of protein synthesis at the level of elongation factor 2, and ion transport across biological membranes.
MSH

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NADH-dehydrogenasa

A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.
MSH

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NADH-tetrazoliumreduktasa

Catalyzes the reduction of tetrazolium compounds in the presence of NADH.
MSH

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NADH, NADPH oxidoreduktasy

A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
MSH

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nadolol

A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor.
MSH

A non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.
NCI

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NADP

Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5`-phosphate (NMN) coupled by pyrophosphate linkage to the 5`-phosphate adenosine 2`,5`-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
MSH

nicotinamide adenine dinucleotide phosphate; a coenzyme composed of ribosylnicotinamide 5`-phosphate (NMN) coupled by pyrophosphate linkage to the 5`-phosphate adenosine 2`,5`-bisphosphate; serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced ( NADPH).
CSP

Nicotinamide Adenine Dinucleotide Phosphate, an oxidation-reduction coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions.
NCI

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NADP-transhydrogenasa

Enzymes that catalyze the reversible reduction of NAD by NADPH to yield NADP and NADH. This reaction permits the utilization of the reducing properties of NADPH by the respiratory chain and in the reverse direction it allows the reduction of NADP for biosynthetic purposes.
MSH

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NADPH-cytochrom c-reduktasa

A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.
MSH

Mammalian NADPH-cytochrome P450 reductase (CPR) was first identified by Horecker in 19501 as an NADPH-specific cytochrome c reductase. CPR was linked to the microsomal electron transport chains, cytochromes P450 and b5, involved in drug and steroid hydroxylations in 1960`s. CPR is a flavoprotein containing both FAD and FMN. It has a modular structure suggestive of its evolution from smaller subunits similar to flavodoxins and ferredoxin NADP+ reductase, and its 3-dimensional structure was recently determined. It is involved in heme catabolism, sterol, bile acid synthesis and fatty acid metabolism. CPR is also a component of nitric oxide synthases and methionine synthase reductase. (http://www.uky.edu/Pharmacy/ps/porter/CPR.htm)
NCI

A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. Its physiological acceptor is probably cytochrome P-450. EC 1.6.2.4.
NCI

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NADPH-dehydrogenasa

A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1.
MSH

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20-alfa-hydroxysteroiddehydrogenasa

An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha-hydroxysteroids, such as from PROGESTERONE to 20-ALPHA-DIHYDROPROGESTERONE.
MSH

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Naegleria

A free-living soil amoeba pathogenic to humans and animals. It occurs also in water and sewage. The most commonly found species in man is NAEGLERIA FOWLERI which is the pathogen for primary amebic meningoencephalitis in primates.
MSH

free living soil amoeba pathogenic to humans and animals; occurs also in water and sewage; most commonly found species in man is Naegleri fowleri which is the pathogen for primary amebic meningoencephalitis in primates.
CSP

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Naegleria fowleri

A species of parasitic protozoa having both an ameboid and flagellate stage in its life cycle. Infection with this pathogen produces PRIMARY AMEBIC MENINGOENCEPHALITIS.
MSH

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nafcilin

A semi-synthetic antibiotic related to penicillin.
MSH

A semi-synthetic naphthalene and beta-lactam antibiotic with antibacterial activity. Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci. (NCI04)
NCI

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nafenopin

A peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an antihyperlipoproteinemic agent.
MSH

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nafoxidin

An estrogen antagonist that has been used in the treatment of breast cancer.
MSH

A triphenylethylene nonsteroidal agent that acts as a partial estrogen antagonist. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)
NCI

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nafronyl

A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.
MSH

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nehty – kousání

Common form of habitual body manipulation which is an expression of tension.
MSH

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nehty – nemoci

Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.
MSH

Your toenails and fingernails protect the tissues of your toes and fingers. They are made up of layers of a hardened protein called keratin, which is also in your hair and skin. Your nails` health can be a clue to your overall health. Healthy nails are usually smooth and consistent in color. Specific types of nail discoloration and changes in growth rate can signal various lung, heart, kidney and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless.

Nail problems that sometimes require treatment include bacterial and fungal infections, ingrown nails, tumors and warts. Keeping nails clean, dry and trimmed can help you avoid some problems. Do not remove the cuticle, which can cause infection.


MEDLINEPLUS

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syndrom nehet-patela

A syndrome of multiple abnormalities characterized by the absence or hypoplasia of the PATELLA and congenital nail dystrophy. It is a genetically determined autosomal dominant trait.
MSH

A rare autosomal dominant syndrome caused by mutations in the LMX1B gene. It is characterized by fingernail deformities, absence or hypoplasia of the patellae, iliac horns, deformities of the radial heads, nephropathy, and glaucoma.
NCI

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