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nikotinylalkohol

Alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE.
MSH

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membrana nictitans

A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.
MSH

third eyelid, present in many animals and vestigial in man, capable of being drawn across the eye ball for protection.
CSP

A translucent membrane present in the eye of some animals, also called the third eye. It is part of the conjunctiva and protects the eye from debris and dry air.
NCI

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Niemannovy-Pickovy nemoci

caused by deficiency of sphingomyelinase, resulting in accumulation of sphingomyelin in the reticuloendothelial system, mental and physical retardation, enlarged liver and spleen, anemia, and blindness.
CSP

An autosomal recessive inherited lysosomal storage disease characterized by deficiency of sphingomyelinase. It results in the accumulation of sphingomyelin in the liver, spleen, brain, lungs, and bone marrow. Signs and symptoms include hepatosplenomegaly, pancytopenia, ataxia, dystonia, and dementia.
NCI

A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.
MSH

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nifedipin

A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
MSH

calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina.
CSP

a drug used for hypertension
CHV

A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
NCI

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kyselina niflumová

An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
MSH

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nifuratel

Local antiprotozoal and antifungal agent that may also be given orally.
MSH

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nifurtimox

A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.
MSH

A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.
NCI

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Niger

A republic in western Africa, north of NIGERIA and west of CHAD. Its capital is Niamey.
MSH

A country in Western Africa, southeast of Algeria. (NCI)
NCI

A country in Western Africa, southeast of Algeria. (CIA World Factbook 2002)
NCI

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Nigérie

A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.
MSH

A country in Western Africa, bordering the Gulf of Guinea, between Benin and Cameroon. (NCI)
NCI

A country in Western Africa, bordering the Gulf of Guinea, between Benin and Cameroon. (CIA World Factbook 2002)
NCI

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nigericin

A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)
MSH

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noční slepota

Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)
MSH

failure or imperfection of vision at night or in dim light, with good vision only on bright days.
CSP

A disorder characterized by an inability to see clearly in dim light.
NCI

An inability to see clearly in dim light; due to a deficiency of vitamin A or to a retinal disorder.
NCI

Inability to see clearly in dim light.
NCI

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noční péče o pacienty

Institutional night care of patients.
MSH

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Noční poty

Nocturnal periods of profuse diaphoresis.
NCI

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Noční můra

A sleep disorder characterized by the repeated occurrence of frightening dreams which precipitate awakenings from sleep; on awakening, the individual becomes fully alert and oriented and has detailed recall of the nightmare, which usually involves imminent danger or extreme embarrassment to the individual.
NCI

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nikethamid

A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)
MSH

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nimodipin

A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
MSH

1,4 dihydropyridine; centrally acting calcium channel blocker used in the treatment of a wide range of disorders, including drug withdrawal, AIDS motor/cognitive disorder, and post cardiac surgery recovery.
CSP

Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy.
NCI

A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41210&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41210&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C692″ NCI Thesaurus)
PDQ

A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.
NCI

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nimorazol

An antitrichomonal agent which is effective either topically or orally and whose urinary metabolites are also trichomonicidal.
MSH

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nimustin

Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
MSH

a kind of cancer treatment drug
CHV

A substance that is being studied in the treatment of brain cancer. It belongs to the family of drugs called nitrosoureas.
NCI

A nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38853&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38853&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C693″ NCI Thesaurus)
PDQ

A nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. (NCI05)
NCI

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ninhydrin

2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.
MSH

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niob

Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)
MSH

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prsní bradavky

The conic organs which usually give outlet to milk from the mammary glands.
MSH

Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle, modified sebaceous glands and papillary part of lactiferous duct.
FMA

The pigmented protuberance on the surface of the breast through which milk is drawn from the breast. (NCI)
NCI

In anatomy, the small raised area in the center of the breast through which milk can flow to the outside.
NCI

Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle, modified sebaceous glands and papillary part of lactiferous duct.
UWDA

The pigmented protuberance on the surface of the breast through which milk is drawn from the breast.
NCI

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Nippostrongylus

genus of intestinal nematode parasites belonging to the superfamily Heligmosomatoidea, which commonly occurs in rats but has been experimentally transmitted to other rodents and rabbits; infection is usually through the skin.
CSP

A genus of intestinal nematode parasites belonging to the superfamily HELIGMOSOMATOIDEA, which commonly occurs in rats but has been experimentally transmitted to other rodents and rabbits. Infection is usually through the skin.
MSH

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niridazol

An antischistosomal agent that has become obsolete.
MSH

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Alphaprodine Hydrochloride

The hydrochloride salt form of alphaprodine, a synthetic piperidine ester, with opioid analgesic activity. Alphaprodine mimics the actions of endogenous neuropeptides by binding to opioid receptors, thereby producing characteristic morphine-like effects via the mu-opioid receptor, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence.
NCI

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nisin

A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
MSH

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nisoldipin

A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
MSH

A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
NCI

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Nisslova tělíska

Subcellular structures found in nerve cell bodies and DENDRITES. They consist of granular endoplasmic reticulum (ENDOPLASMIC RETICULUM, ROUGH) and RIBOSOMES.
MSH

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nitrakrin

Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
MSH

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nitrátreduktasy

Oxidoreductases that are specific for the reduction of NITRATES.
MSH

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dusičnany

Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
MSH

A class of ester compounds of nitric acid (HNO3) and alcohols.
NCI

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