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olivomyciny

A mixture of several closely related glycosidic antibiotics obtained from Actinomyces (or Streptomyces) olivoreticuli. They are used as fluorescent dyes that bind to DNA and prevent both RNA and protein synthesis and are also used as antineoplastic agents.
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olivopontocerebelární atrofie

A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)
MSH

A group of sporadic and inherited neurodegenerative disorders affecting the cerebellum, pons, and inferior olives.
NCI

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Omán

A sultanate on the southeast coast of the Arabian peninsula. Its capital is Masqat. Before the 16th century it was ruled by independent emirs but was captured and controlled by the Portuguese 1508-1648. In 1741 it was recovered by a descendent of Yemen`s imam. After its decline in the 19th century, it became virtually a political and economic dependency within the British Government of India, retaining close ties with Great Britain by treaty from 1939 to 1970 when it achieved autonomy. The name was recorded by Pliny in the 1st century A.D. as Omana, said to be derived from the founder of the state, Oman ben Ibrahim al-Khalil. (From Webster`s New Geographical Dictionary, 1988, p890; Oman Embassy, Washington; Room, Brewer`s Dictionary of Names, 1992, p391)
MSH

A country in the Middle East, bordering the Arabian Sea, Gulf of Oman, and Persian Gulf, between Yemen and the United Arab Emirates. (NCI)
NCI

A country in the Middle East, bordering the Arabian Sea, Gulf of Oman, and Persian Gulf, between Yemen and the United Arab Emirates. (CIA World Factbook 2002)
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kniha (omasum)

The third stomach of ruminants, situated on the right side of the abdomen at a higher level than the fourth stomach and between this latter and the second stomach, with both of which it communicates. From its inner surface project large numbers of leaves or folia, each of which possesses roughened surfaces. In the center of each folium is a band of muscle fibers which produces a rasping movement of the leaf when it contracts. One leaf rubs against those on either side of it, and large particles of food material are ground down between the rough surfaces, preparatory to further digestion in the succeeding parts of the alimentary canal. (Black`s Veterinary Dictionary, 17th ed)
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omentum

A double-layered fold of peritoneum that attaches the STOMACH to other organs in the ABDOMINAL CAVITY.
MSH

A fold of the peritoneum (the thin tissue that lines the abdomen) that surrounds the stomach and other organs in the abdomen.
NCI

A fold of peritoneum originating at the stomach and supporting the viscera.
NCI

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omeprazol

A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.
MSH

substituted benzimidazole used as a gastric acid secretion inhibitor.
CSP

A drug that inhibits gastric acid secretion.
NCI

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic properties and does not antagonize histamine H2 receptors. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C716″ NCI Thesaurus)
PDQ

A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ – K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.
NCI

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Onchocerca

A genus of parasitic nematodes whose organisms live and breed in skin and subcutaneous tissues. Onchocercal microfilariae may also be found in the urine, blood, or sputum.
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Onchocerca volvulus

A species of parasitic nematodes widely distributed throughout central Africa and also found in northern South America, southern Mexico, and Guatemala. Its intermediate host and vector is the blackfly or buffalo gnat.
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onchocerkóza

Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
MSH

infection with nematodes of the genus Onchocerca; characteristics include the presence of firm subcutaneous nodules filled with adult worms, pruritus, and ocular lesions.
CSP

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onchocerkóza oční

Filarial infection of the eyes transmitted from person to person by bites of Onchocerca volvulus-infected black flies. The microfilariae of Onchocerca are thus deposited beneath the skin. They migrate through various tissues including the eye. Those persons infected have impaired vision and up to 20% are blind. The incidence of eye lesions has been reported to be as high as 30% in Central America and parts of Africa.
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onkogenní proteiny

Proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (ONCOGENE PROTEINS, FUSION).
MSH

proteins coded by oncogenes which potentially induce neoplastic transformation.
CSP

A general term referring to the gene product of an oncogene.
NCI

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onkogenní protein p21(ras)

Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.
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onkogenní protein pp60(v-src)

A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.
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onkogenní protein tpr-met

The GENETIC TRANSLATION product from a GENE FUSION between a sequence from the tpr protein gene on the human CHROMOSOME 1 and the gene for PROTO-ONCOGENE PROTEINS C-MET.
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onkogenní proteiny fúzové

The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
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onkogenní proteiny virové

Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
MSH

Proteins expressed by virally mutated genes that once played a normal role in the cell as a proto-oncogene. There are several different types of viral oncogene proteins, and the expression of these proteins contributes to a transformed phenotype in cells.
NCI

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onkogeny

Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of “v-” before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix “c-” before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
MSH

endogenous or acquired genes whose presence or activation leads to neoplastic transformation; compare with TUMOR SUPPRESSOR GENE and PROTOONCOGENE.
CSP

A gene that is a mutated (changed) form of a gene involved in normal cell growth. Oncogenes may cause the growth of cancer cells. Mutations in genes that become oncogenes can be inherited or caused by being exposed to substances in the environment that cause cancer.
NCI

A gene that normally directs cell growth. If mutated or overexpressed in a dominant fashion, it can release the cell from normal restraints on growth. It alone or in concert with other changes, converts the cell into a tumor cell. Alterations can be inherited or caused by an environmental exposure to carcinogens.
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viry onkogenní

Viruses that produce tumors.
MSH

viruses that produce tumors; see RTs for specific organisms.
CSP

A virus capable of transforming a cell to a malignant phenotype. (BioTech Life Science Dictionary)
NCI

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onkologické ošetřovatelství

Nursing care provided cancer patients. It includes aspects of family functioning through education of both patient and family. The specialty of oncologic nursing focuses on cancer as a major health care problem.
MSH

nursing care provided cancer patients; includes aspects of family functioning through education of both patient and family.
CSP

Nursing that focuses on treating and caring for people who have cancer.
NCI

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onkolytické viry

A type of virus that infects and lyses (breaks down) cancer cells but not normal cells. Oncolytic viruses can occur naturally or can be made in the laboratory by changing other viruses. Certain oncolytic viruses are being studied in the treatment of cancer. They may make it easier to kill tumor cells with chemotherapy and radiation therapy.
NCI

Manipulated or engineered viruses having oncolytic properties to selectively replicate in and kill targeted cancer cells, leaving normal cells unharmed.
NCI

Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
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Oncorhynchus

A genus of the family SALMONIDAE (salmons and trouts). They are named for their hooked (onco) nose (rhynchus). They are usually anadromous and occasionally inhabit freshwater. They can be found in North Pacific coastal areas from Japan to California and adjacent parts of the Arctic Ocean. Salmon and trout are popular game and food fish. Various species figure heavily in genetic, metabolism, and hormone research.
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česneky

Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.
MSH

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oniové sloučeniny

Ions with the suffix -onium, indicating cations with coordination number 4 of the type RxA+ which are analogous to QUATERNARY AMMONIUM COMPOUNDS (H4N+). Ions include phosphonium R4P+, oxonium R3O+, sulfonium R3S+, chloronium R2Cl+
MSH

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on-line systémy

Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
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jedináček

Child who has no siblings.
MSH

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Ontario

A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster`s New Geographical Dictionary, 1988, p892 & Room, Brewer`s Dictionary of Names, 1992, p391)
MSH

A province in east-central Canada bordered by Quebec to the east and Manitoba to the west.
NCI

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oocyty

Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
MSH

Germ cell of the female sex.
UWDA

The female gamete, germ cells in stages between the prophase of the first maturation division and the completion of the second maturation division.
NCI

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oogeneze

The process of germ cell development in the female from the primordial germ cells through OOGONIA to the mature haploid ova (OVUM).
MSH

process of germ cell development in the female from the primordial germ cells through oogonia to the mature haploid ova.
CSP

The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. [GOC:kmv, GOC:mtg_sensu]
GO

The development of ovum, which are the female germ cells. Oogenesis occurs by meiosis and is essential for the production of mature eggs.
NCI

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oogonie

Euploid female germ cells of an early stage of OOGENESIS, derived from primordial germ cells during ovarian differentiation. Oogonia undergo MEIOSIS and give rise to haploid OOCYTES
MSH

The primitive differentiated female gamete which gives rise to an oocyte. (MeSH)
NCI

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ooforitida

Inflammation of the OVARY, generally caused by an ascending infection of organisms from the endocervix.
MSH

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