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fibrin

A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
MSH

insoluble protein that forms a network of fibers during blood clotting; derived from fibrinogen in the presence of thrombin.
CSP

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fibrinová pěna

A dry artificial sterile sponge of fibrin prepared by clotting with thrombin a foam or solution of fibrinogen. It is used in conjunction with thrombin as a hemostatic in surgery at sites where bleeding cannot be controlled by more common methods. (From Martindale, The Extra Pharmacopoeia, 30th ed, p648)
MSH

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fibrinová tkáňová adheziva

An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.
MSH

A substance used during surgery to help heal wounds. It contains proteins found in human blood that cause blood to clot. When fibrin sealant is placed on a wound, a clot forms. Fibrin sealant is being studied as a way to improve healing after lymph node removal in patients with cancer. It is a type of surgical glue.
NCI

A plasma-derived fibrin biomatrix preparation consisting of two separate solutions that are combined on application. The sealer protein solution contains clottable human fibrinogen and bovine aprotinin, a fibrinolysis inhibitor; the thrombin solution contains human thrombin and calcium chloride. When the solutions are combined, a clot is formed, reproducing the final stages of the coagulation cascade. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38531&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38531&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2664″ NCI Thesaurus)
PDQ

A plasma-derived fibrin biomatrix preparation consisting of two separate solutions that are combined on application. The sealer protein solution contains clottable human fibrinogen and bovine aprotinin, a fibrinolysis inhibitor; the thrombin solution contains human thrombin and calcium chloride. When the solutions are combined, a clot is formed, reproducing the final stages of the coagulation cascade.
NCI

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fibrinogen

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
MSH

plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds; fibrinogen clotting is a sol-gel change involving complex molecular arrangements.
CSP

A fibrillar protein present in blood plasma; it converts to fibrin during the process of blood clot formation.
NCI

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trombocytový glykoproteinový komplex IIb-IIIa

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
MSH

Integrin Alpha-IIb/Beta3 is protein complex comprised of a heterodimer of integrin alpha 2b and integrin beta 3. This complex is involved in cell adhesion and blood clot formation.
NCI

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fibrinogeny abnormální

Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
MSH

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plasmin

serine endopeptidase occurring in plasma as plasminogen, activated via cleavage by plasminogen activators solubilizes fibrin clots and also degrades various proteins including fibrinogen and coagulation factors V and VII.
CSP

A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
MSH

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fibrinolýza

The natural enzymatic dissolution of FIBRIN.
MSH

natural enzymatic dissolution of fibrin.
CSP

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots. [GOC:jl, PMID:15842654]
GO

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fibrinolytika

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
MSH

fibrinolysin or agents that convert plasminogen to fibrinolysin to dissolve blood clots.
CSP

a drug used to dissolve blood clots
CHV

Any agent capable of dissolving an existing blood clot in order to reperfuse the blocked blood vessel.
NCI

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fibrinopeptid A

Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.
MSH

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fibrinopeptid B

Two small peptide chains removed from the N-terminal segment of the beta chains of fibrinogen by the action of thrombin. Each peptide chain contains 20 amino acid residues. The removal of fibrinopeptides B is not required for coagulation.
MSH

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fibroblastové růstové faktory

family of structurally related polypeptides which have important roles in cell development, differentiation, and motility, as well as angiogenesis, neurogenesis, wound healing, and tumor growth.
CSP

A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
MSH

Peptide isolated from the pituitary gland and from the brain. It is a potent mitogen which stimulates growth of a variety of mesodermal cells including chondrocytes, granulosa, and endothelial cells. The peptide may be active in wound healing and animal limb regeneration.
NCI

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fibroblasty

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
MSH

connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
CSP

A connective tissue cell that makes and secretes collagen proteins.
NCI

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fibrocystická nemoc prsu

A common condition marked by benign (not cancer) changes in breast tissue. These changes may include irregular lumps or cysts, breast discomfort, sensitive nipples, and itching. These symptoms may change throughout the menstrual cycle and usually stop after menopause.
NCI

A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.
MSH

Fibrosis associated with cyst formation in the breast parenchyma. — 2003
NCI

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Fibrodysplasia ossificans progressiva

disease characterized by bony deposits or the ossification of muscle tissue.
CSP

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fibroiny

Fibrous proteins secreted by INSECTS and SPIDERS. Generally, the term refers to silkworm fibroin secreted by the silk gland cells of SILKWORMS, Bombyx mori. Spider fibroins are called spidroins or dragline silk fibroins.
MSH

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fibrom

A benign tumor of fibrous or fully developed connective tissue.
MSH

benign tumor of fibrous or fully developed connective tissue.
CSP

A benign neoplasm arising from the fibrous tissues. It is characterized by the presence of spindle-shaped fibroblasts.
NCI

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Fibromatóza

A condition in which multiple fibromas develop. Fibromas are tumors (usually benign) that affect connective tissue.
NCI

A poorly circumscribed neoplasm arising from the soft tissues. It is characterized by the presence of spindle-shaped fibroblasts and an infiltrative growth pattern.
NCI

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fibromatóza dásní

Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)
MSH

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fibromuskulární dysplazie

An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.
MSH

A disorder characterized by fibrous thickening of the arterial wall resulting in narrowing of the arterial lumen. It most often affects the renal artery and less often the carotid artery and abdominal arteries. It can cause hypertension and aneurysm formation.
NCI

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fibromyalgie

A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
MSH

an acute, subacute, or chronic painful state of muscles, subcutaneous tissues, ligaments, tendons, or fasciae caused by a number of agents such as trauma, strain, occupation, exposure, posture, infection, or arthritis.
CSP

Inflammation and fibrous degeneration of a muscle.
NCI

Fibromyalgia makes you feel tired and causes muscle pain and "tender points." Tender points are places on the neck, shoulders, back, hips, arms or legs that hurt when touched. People with fibromyalgia may have other symptoms, such as trouble sleeping, morning stiffness, headaches, and problems with thinking and memory, sometimes called "fibro fog."

No one knows what causes fibromyalgia. Anyone can get it, but it is most common in middle-aged women. People with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. There is no cure for fibromyalgia, but medicines can help you manage your symptoms. Getting enough sleep and exercising may also help.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases


MEDLINEPLUS

Inflammation and fibrous degeneration of a muscle.
NCI

A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation.
NCI

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fibronektiny

Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
MSH

adhesive glycoprotein found in blood (as an opsonin and platelet aggregation factor), connective tissue (as a collagen crosslinker), and bound to cell surfaces (as a cell adhesion protein).
CSP

Encoded as alternative isoforms by human FN1 Gene, 2386-aa 262.6-kD Fibronectin precursor is a sulfated disulfide bound glycoprotein with multiple type I, II, and III fibronectin domains. MSF FN70 is an isoform. Plasma (hepatocytes) and cellular (fibroblasts and epithelia) FN differ in activity. Cell surface cellular FN (di/multimeric) is deposited in the ECM. FN is involved in embryogenesis, cell adhesion, migration, and motility, opsonization, wound healing, coagulation, host defense, cell shape, and metastasis. It stimulates endocytosis and may promote clearance of C1q-coated immune complexes. FN binds cell surface integrin, C1q, collagen, fibrin, hyaluronic acid, heparin, FBLN1, and actin. Most cells depend on FN to bind collagen. Talin-1 may link FN/Integrin with the actin cytoskeleton. FN may promote contact inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)
NCI

Fibronectin (FN) is a multifunctional adhesive glycoprotein found in blood, in connective tissue, and on cell surfaces. The plasma and cellular forms differ in biologic activity and arise from a single gene by alternative splicing. Fibronectins function as adhesive ligand-like molecules in cell adhesion, morphology, and surface architecture. The absence of fibronectin causes a loss of contact inhibition in transformed cells. While hepatocytes and smooth muscle cells have collagen receptors, most other cells depend on fibronectin for binding to collagen and thus adhesion of cells to extracellular substrata and matrices. Separate binding domains in fibronectin have been identified for (NH2-end) heparin, collagen, cells, hyaluronic acid, and heparin (COOH-end). Fibronectin binds to C1q in the same manner that it binds collagen and may promote clearance of C1q-coated immune complexes or cellular debris. (from OMIM and NCI)
NCI

Fibronectin (FN) is involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion. Fibronectin exists in two main forms: 1) as an insoluble glycoprotein dimer that serves as a linker in the ECM (extracellular matrix), and; 2) as a soluble disulphide linked dimer found in the plasma (plasma FN). The plasma form is synthesized by hepatocytes, and the ECM form is made by fibroblasts, chondrocytes, endothelial cells, macrophages, as well as certain epithelial cells. Fibronectin sometimes serves as a general cell adhesion molecule by anchoring cells to collagen or proteoglycan substrates.
NCI

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fibrosarkom

A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
MSH

sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream.
CSP

A malignant mesenchymal tumor showing fibroblastic differentiation affecting soft tissues and bone.
NCI

A malignant mesenchymal tumor affecting soft tissues and bone. It is classified as adult or infantile. Infantile fibrosarcomas generally have a much more favorable prognosis than adult fibrosarcomas.
NCI

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fibróza

Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
MSH

development of excess fibrous connective tissue in an organ.
CSP

The growth of fibrous tissue.
NCI

The formation of fibrous tissue; fibroid or fibrous degeneration.
NCI

formation of excess fibrous connective tissue
CHV

The formation of fibrous tissue; fibroid or fibrous degeneration.
NCI

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fibrózní dysplazie kosti

A disease of bone marked by thinning of the cortex and replacement of bone marrow by gritty fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC). (From Dorland, 28th ed)
MSH

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fibrózní dysplazie monostotická

FIBROUS DYSPLASIA OF BONE involving only one bone.
MSH

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fibrózní dysplazie polyostotická

FIBROUS DYSPLASIA OF BONE affecting several or many bones. When associated with melanotic pigmentation of the skin and endocrine disorders, it is known as Albright`s syndrome. (From Dorland, 28th ed)
MSH

A genetic syndrome caused by mutations in the GNAS1 gene. It is characterized by deformities and fractures of the bones, endocrine abnormalities including early puberty, and skin hyperpigmentation.
NCI

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fibula

The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.
MSH

The small, lateral calf bone extending from the knee to the ankle. (NCI)
NCI

The small, lateral calf bone extending from the knee to the ankle.
NCI

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fikain

A sulfhydryl proteinase with cysteine at the active site from ficus latex. Preferential cleavage is at tyrosine and phenylalanine residues. EC 3.4.22.3.
MSH

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fikoll

A sucrose polymer of high molecular weight.
MSH

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