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Phenelzine Sulfate

A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects.
NCI

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fenylethanolamin-N-methyltransferasa

A methyltransferase that catalyzes the reaction of S-adenosyl-L-methionine and phenylethanolamine to yield S-adenosyl-L-homocysteine and N-methylphenylethanolamine. It can act on various phenylethanolamines and converts norepinephrine into epinephrine. (From Enzyme Nomenclature, 1992) EC 2.1.1.28.
MSH

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fenethylalkohol

An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
MSH

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fenethylaminy

A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)
MSH

group of compounds that are derivatives of beta- aminoethylbenzene, structurally and pharmacologically related to amphetamine.
CSP

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fenetidin

Used in the manufacture of acetophenetidin.
MSH

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fenformin

A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
MSH

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fenindion

An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
MSH

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feniramin

One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
MSH

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fenmetrazin

A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.
MSH

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fenobarbital

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
MSH

barbituric acid derivative that acts as a nonselective central nervous system depressant.
CSP

A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.
NCI

a drug used for epilepsy and anxiety
CHV

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42405&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C739″ NCI Thesaurus)
PDQ

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.
NCI

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fenolftaleiny

A family of 3,3-bis(p-hydroxyphenyl)phthalides. They are used as CATHARTICS, indicators, and COLORING AGENTS.
MSH

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fenoly

any organic compound containing one or more hydroxyl groups attached to a benzene ring.
CSP

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fenolsulfonftalein

Red dye, pH indicator, and diagnostic aid for determination of renal function. It is used also for studies of the gastrointestinal and other systems.
MSH

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fenoperidin

A narcotic analgesic partly metabolized to meperidine in the liver. It is similar to morphine in action and used for neuroleptanalgesia, usually with droperidol.
MSH

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phenothiazine

A type of drug that is used to treat severe mental and emotional disorders, severe nausea and vomiting, and certain other conditions. It belongs to the families of drugs called antipsychotics and antiemetics.
NCI

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fenothiaziny

Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
MSH

3-ring structure of two benzene rings joined by a sulfur and a nitrogen atom; an important class of antipsychotic and other drugs which act by disrupting monoamine transmitter systems.
CSP

A class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI)
NCI

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fenotyp

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
MSH

the entire physical, biochemical, and physiological makeup of an individual as determined both genetically and environmentally; also, any one or any group of such traits.
CSP

The observable characteristics in an individual resulting from the expression of genes; the clinical presentation of an individual with a particular genotype.
NCI

Description:A genomic phenomenon that is expressed externally in the organism.


HL7V3.0

The assemblage of traits or outward appearance of an individual. It is the product of interactions between genes and between genes and the environment.
NCI

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fenoxybenzamin

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
MSH

A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
NCI

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fenprokumon

Coumarin derivative that acts as a long acting oral anticoagulant.
MSH

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fentermin

A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
MSH

A natural monoamine alkaloid derivative and a sympathomimetic stimulant with appetite suppressant property. Phentermine, which was part of the Fen-Phen anti-obesity medication, stimulates hypothalamic release of norepinephrine, a neurotransmitter involved in stress responses (fight-or-flight reactions), and reduces hunger sensation. Phentermine also causes the release of epinephrine or adrenaline outside of the brain, resulting in breakdown of stored fat.
NCI

central nervous system stimulant and sympathomimetic with actions and uses similar to dextroamphetamine; used in the treatment of obesity.
CSP

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fentolamin

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
MSH

nonselective alpha-adrenergic antagonist.
CSP

A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.
NCI

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fenylethery

Ethers that are linked to a benzene ring structure.
MSH

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fenylalanin

An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
MSH

essential aromatic amino acid that is a precursor of melanin, dopamine, norepinephrine and thyroxine.
CSP

Amino acid with side chain -CH2C6H5.
NCI

An essential aromatic amino acid in humans (provided by food), Phenylalanine plays a key role in the biosynthesis of other amino acids and is important in the structure and function of many proteins and enzymes. Phenylalanine is converted to tyrosine, used in the biosynthesis of dopamine and norepinephrine neurotransmitters. The L-form of Phenylalanine is incorporated into proteins, while the D-form acts as a painkiller. Absorption of ultraviolet radiation by Phenylalanine is used to quantify protein amounts. (NCI04)
NCI

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fenylalaninamoniaklyasa

An enzyme that catalyzes the deamination of PHENYLALANINE to form trans-cinnamate and ammonia.
MSH

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fenylalaninhydroxylasa

An enzyme of the oxidoreductase class that catalyzes the formation of L-TYROSINE, dihydrobiopterin, and water from L-PHENYLALANINE, tetrahydrobiopterin, and oxygen. Deficiency of this enzyme may cause PHENYLKETONURIAS and PHENYLKETONURIA, MATERNAL. EC 1.14.16.1.
MSH

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fenylalanin-tRNA-ligasa

An enzyme that activates phenylalanine with its specific transfer RNA. EC 6.1.1.20.
MSH

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fenylbutazon

A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
MSH

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fenylbutyráty

cytostatic, apoptosis inducing agent; effects cell differentiation.
CSP

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fenylefrin

An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
MSH

direct acting sympathomimetic amine that stimulates alpha-adrenergic receptors and is a powerful vasoconstrictor.
CSP

A direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.
NCI

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Phenylephrine Hydrochloride

The hydrochloride salt form of phenylephrine, a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.
NCI

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