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piperacilin

Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
MSH

A broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic. Piperacillin binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, a critical component of the bacterial cell wall. This blockade leads to the interruption of cell wall synthesis, consequently, leading to bacterial cell growth inhibition and cell lysis.
NCI

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piperazine

saturated 6-membered ring structure with 2 nitrogen atoms.
CSP

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piperidine

saturated 6-membered ring structure with one nitrogen atom.
CSP

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piperidiny

A family of hexahydropyridines.
MSH

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piperonylbutoxid

An insecticide synergist, especially for pyrethroids and ROTENONE.
MSH

A synthetic derivative of benzodioxole and used as an insecticide synergist, Piperonyl Butoxide enhances the active properties of pyrethrin, pyrethroid, rotenone, and carbamate pesticide ingredients by inhibiting insect microsomal enzyme detoxification activity. It is toxic and suspected of causing anorexia, carcinogenesis, convulsions, and dermal irritation, as well as hepatic and renal damage. (NCI04)
NCI

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piperoxan

A benzodioxane alpha-adrenergic blocking agent with considerable stimulatory action. It has been used to diagnose PHEOCHROMOCYTOMA and as an antihypertensive agent.
MSH

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Pipidae

A family of the order Anura, distinguished by the lack of a tongue. It includes four living genera of aquatic “toads”. Two of the most familiar pipids are the popularly called Surinam “toad” (Pipa pipa) and XENOPUS LAEVIS.
MSH

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pipobroman

An antineoplastic agent that acts by alkylation.
MSH

A piperazine derivative with potential antineoplastic alkyating activity. Although the exact mechanism of action of pipobroman has yet to be fully elucidated, this agent appears to act by alkylating DNA, leading to disruption of DNA replication and eventually cell death.
NCI

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piracetam

A compound suggested to be both a nootropic and a neuroprotective agent.
MSH

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pirenzepin

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
MSH

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piribedil

A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist.
MSH

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pirinitramid

A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.
MSH

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kyselina piromidová

Antibacterial against mainly gram negative organisms. It is used for urinary tract and intestinal infections.
MSH

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piroxikam

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
MSH

4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2- benzothiazine-3-carboxamide- 1,1-dioxide; nonsteroidal antiinflammatory drug (NSAID) which functions by inhibiting prostaglandin synthesis; effective against colon cancer.
CSP

A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39761&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39761&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C751″ NCI Thesaurus)
PDQ

A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.
NCI

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tmely pro jamky a fisury

Agents used to occlude dental enamel pits and fissures in the prevention of dental caries.
MSH

A pit and fissure sealant and conditioner is a device composed of resin, such as polymethylmethacrylate, intended for use primarily in young children to seal pit and fissure depressions (faults in the enamel) in the biting surfaces of teeth to prevent cavities.
SPN

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Pitcairn Island

An island in Polynesia, in the south Pacific Ocean. It was discovered in 1767 by Philip Carteret, uninhabited until 1790 when settled by mutineers from the English ship, Bounty. The settlement was discovered in 1808; the population was removed temporarily to Tahiti in 1831 and to Norfolk Island (between New Caledonia and New Zealand) in 1856. Some later returned to Pitcairn and their descendents constitute the present population of this British colony. The island is named for the midshipman who first sighted it from the ship. (From Webster`s New Geographical Dictionary, 1988, p958 & Room, Brewer`s Dictionary of Names, 1992, p422)
MSH

A country in the Pacific, comprised of islands in the South Pacific Ocean, about midway between Peru and New Zealand. (NCI)
NCI

A country in the Pacific, comprised of islands in the South Pacific Ocean, about midway between Peru and New Zealand. (CIA World Factbook 2002)
NCI

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výška zvuku – diskriminace

The ability to differentiate tones.
MSH

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výška zvuku – percepce

A dimension of auditory sensation varying with cycles per second of the sound stimulus.
MSH

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adenom hypofýzy

A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa. A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss.
NCI

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hypofýza – apoplexie

The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.
MSH

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nemoci hypofýzy

Disorders involving either the ADENOHYPOPHYSIS or the NEUROHYPOPHYSIS. These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. Neoplastic pituitary masses can also cause compression of the OPTIC CHIASM and other adjacent structures.
MSH

disorders of the anterior or posterior pituitary gland which usually manifest as hypersecretion or hyposecretion of pituitary hormones.
CSP

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" – it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.


MEDLINEPLUS

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hypofýza

A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk.
MSH

epithelial body located at the base of the brain in the sella turcica, attached by a stalk to the hypothalamus from which it receives important neural and vascular outflow; it consists of the anterior lobe, or adenohypophysis, which secretes most of the hormones, the posterior lobe or neurohypophysis, which stores and releases neurohormones that it receives from the hypothalamus, and an intermediate lobe.
CSP

The main endocrine gland. It produces hormones that control other glands and many body functions, especially growth.
NCI

Pea-sized endocrine gland located at the base of the brain in the pituitary fossa. It produces and secretes hormones such as oxytocin and vasopressin, to regulate the activities of the hypothalamus.
NCI

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hypofýza – přední lalok

The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.
MSH

The glandular or anterior lobe of the pituitary gland which secretes several hormones.
NCI

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hypofýza – zadní lalok

Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
MSH

posterior lobe of the pituitary gland, making up the neural portion, including the infundibulum or neural stalk, continuous with the hypothalamus; serves as a reservoir for neurohormones vasopressin, oxytocin, and neurophysin.
CSP

The neural or post-neural lobe of the pituitary gland which stores and releases vasopressin, oxytocin, and neurophysins.
NCI

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hormony inhibující uvolňování hypofyzárního hormonu

Polypeptide hormones produced in the hypothalamus which inhibit the release of pituitary hormones. Used for PHRIH in general or for which there is no specific heading.
MSH

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hormony uvolňující hypofyzární hormony

Peptides, natural or synthetic, that stimulate the release of PITUITARY HORMONES. They were first isolated from the extracts of the HYPOTHALAMUS; MEDIAN EMINENCE; PITUITARY STALK; and NEUROHYPOPHYSIS. In addition, some hypophysiotropic hormones control pituitary cell differentiation, cell proliferation, and hormone synthesis. Some can act on more than one pituitary hormone.
MSH

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hypofyzární hormony

Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.
MSH

hormones secreted by the pituitary gland including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the intermediate lobe; they include small peptides, proteins, and glycoproteins; they are under the regulation of neural signals or neuroendocrine signals from the hypothalamus as well as feedback from their targets.
CSP

Pituitary hormones are produced by the pituitary gland, the master gland of the endocrine system which is located at the base of the brain. Levels of pituitary hormones are regulated by the hypothalamus, anterior and posterior lobes of the pituitary gland, and by the pars intermedia.
NCI

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adenohypofyzární hormony

Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Structurally, they include polypeptide, protein, and glycoprotein molecules.
MSH

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neurohypofyzární hormony

Hormones released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). They include a number of peptides which are formed in the NEURONS in the HYPOTHALAMUS, bound to NEUROPHYSINS, and stored in the nerve terminals in the posterior pituitary. Upon stimulation, these peptides are released into the hypophysial portal vessel blood.
MSH

hormones released from the posterior lobe of the pituitary, including vasopressin (antidiuretic hormone) and oxytocin; formed in the neuronal cells of the hypothalamic nuclei and stored in nerve cell endings in the posterior pituitary.
CSP

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nádory hypofýzy

Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
MSH

new abnormal pituitary tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the “master control gland” – it makes hormones that affect growth and the functions of other glands in the body.

Pituitary tumors are fairly common. About 1 in 10,000 people get them. They grow slowly, do not spread and are usually not cancerous. The most common type of pituitary tumor produces hormones and disrupts the balance of hormones in your body. This can cause endocrine diseases such as Cushing`s syndrome and hyperthyroidism.

Symptoms of pituitary tumors include

  • Headaches
  • Vision problems
  • Nausea and vomiting
  • Any of the problems caused by the production of too many hormones

Pituitary tumors are usually curable. Treatment is often surgery to remove the tumor. Other options include medicines and radiation.


MEDLINEPLUS

A tumor that forms in the pituitary gland. The pituitary is a pea-sized organ in the center of the brain above the back of the nose. It makes hormones that affect other glands and many body functions, especially growth. Most pituitary tumors are benign (not cancer).
NCI

A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland.
NCI

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