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poliomyelitida bulbární

A form of paralytic poliomyelitis affecting neurons of the MEDULLA OBLONGATA of the brain stem. Clinical features include impaired respiration, HYPERTENSION, alterations of vasomotor control, and dysphagia. Weakness and atrophy of the limbs and trunk due to spinal cord involvement is usually associated. (From Adams et al., Principles of Neurology, 6th ed, p765)
MSH

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poliovirové vakcíny

vaccine used to prevent poliomyelitis, including inactivated and oral vaccines.
CSP

Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).
MSH

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poliovirová vakcína orální

A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
MSH

poliovirus vaccine, live, oral


HL7V3.0

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politické systémy

The units based on political theory and chosen by countries under which their governmental power is organized and administered to their citizens.
MSH

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politika

Activities concerned with governmental policies, functions, etc.
MSH

activities or affairs engaged in by a government, politician, or political party.
CSP

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pyl

The fertilizing element of plants that contains the male GAMETOPHYTES.
MSH

fine powderlike material consisting of pollen grains that is produced by the anthers of seed plants, such as flowers, grasses and trees that may cause allergic reactions in some individuals.
CSP

The male genetic material of a seed plant contained in the anther, usually appearing as fine grains or dust.
NCI

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polonium

Polonium. A radioactive element that is a member of the chalcogen family. It has the atomic symbol Po, atomic number 84, and the atomic weight of the isotope with the longest half-life (209Po) is 208.98. It decays by alpha-emission.
MSH

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poloxalen

A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
MSH

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poly A

A group of adenine ribonucleotides in which the phosphate residues of each adenine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

homopolymer composed solely of adenylate residues.
CSP

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polynukleotidadenylyltransferasa

An enzyme that catalyzes the synthesis of polyadenylic acid from ATP. May be due to the action of RNA polymerase (EC 2.7.7.6) or polynucleotide adenylyltransferase (EC 2.7.7.19). EC 2.7.7.19.
MSH

Nuclear or cytoplasmic human Riboadenylate Transferases (Poly A Polymerase Family) catalyze template-independent post-transcriptional extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity during eukaryotic mRNA maturation. The N-terminal region appears required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. (NCI)
NCI

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poly A-U

A double-stranded polyribonucleotide comprising polyadenylic and polyuridylic acids.
MSH

A synthetic polyadenylic-polyuridylic acid double-stranded RNA. Poly AU may stimulate the release of cytotoxic cytokines and, by inducing the production of interferon, may increase the number and tumoricidal activities of various immunohematopoietic cells. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39557&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39557&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C757″ NCI Thesaurus)
PDQ

A synthetic polyadenylic-polyuridylic acid double-stranded RNA. Poly AU may stimulate the release of cytotoxic cytokines and, by inducing the production of interferon, may increase the number and tumoricidal activities of various immunohematopoietic cells. (NCI04)
NCI

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polyadenosindifosfátribosa

A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.
MSH

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poly(ADP-ribosa)-polymerasy

The human protein poly(ADP ribose) polymerase protein (1013aa, ~113 kDa) is encoded by the PARP1 gene (PARP1). Poly(ADP ribose) polymerase (PARP) is a cytosolic protein, and when activated is cleaved into two fragments of 89kd and 24kd. The enzyme modifies various nuclear proteins by poly ADP-ribosylation. The protein is involved in the regulation of various important cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage. Its inhibition has been studied in cancerous cells and degenerative diseases to demonstrate how apoptosis can be inhibited when the PARP is inactive or absent.
NCI

An enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. Inhibitors of PARP-1 are being studied in the treatment of cancer.
NCI

Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
MSH

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poly C

A group of cytosine ribonucleotides in which the phosphate residues of each cytosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

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poly dA-dT

Polydeoxyribonucleotides made up of deoxyadenine nucleotides and thymine nucleotides. Present in DNA preparations isolated from crab species. Synthetic preparations have been used extensively in the study of DNA.
MSH

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poly G

A group of guanine ribonucleotides in which the phosphate residues of each guanine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

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poly I

A group of inosine ribonucleotides in which the phosphate residues of each inosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

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poly I-C

Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.
MSH

interferon inducer consisting of a synthetic, mismatched double-stranded RNA; the polymer is made of one strand each of polyinosinic acid and polycytidylic acid.
CSP

A synthetic polyinosinic-polycytidylic acid double-stranded RNA. Poly IC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the number and tumoricidal activities of various immunohematopoietic cells. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39558&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39558&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C758″ NCI Thesaurus)
PDQ

A synthetic polyinosinic-polycytidylic acid double-stranded RNA. Poly IC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the number and tumoricidal activities of various immunohematopoietic cells. (NCI04)
NCI

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poly T

A group of thymine nucleotides in which the phosphate residues of each thymine nucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
MSH

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poly U

A group of uridine ribonucleotides in which the phosphate residues of each uridine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
MSH

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polyaminy

compounds containing two or more amine groups.
CSP

A class or organic compounds composed of carbon, hydrogen, and nitrogen containing two or more amino groups with some compounds acting as essential growth factors for microorganisms.
NCI

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polyanetholsulfonan

A compound originally developed as an anticoagulant, but possessing anticomplement action and lowering the bactericidal action of blood. It is used in vitro to inhibit blood coagulation and as a diagnostic reagent to encourage the growth of pathogens in the blood. It is also used to stabilize colloidal solutions such as milk and gelatin. (From Merck Index, 11th ed)
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polybrombifenylové sloučeniny

Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.
MSH

A mixture of synthetic solids, containing three or more bromine atoms, that is virtually insoluble in water but is soluble in fat and various organic solvents. There are 209 different molecular combinations, or congeners, that are possible for polybrominated biphenyls. These mixtures are no longer used or produced in commercial quantities in the United States. Residues remaining in and around plants that formerly manufactured, processed or produced products using polybrominated biphenyls are the current sources for human exposure. The primary routes of potential human exposure to polybrominated biphenyls are ingestion, inhalation, and dermal contact. A commercial mixture of these compounds is reasonably anticipated to be a human carcinogen. (NCI05)
NCI

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polykarboxylátový cement

Water-soluble low-molecular-weight polymers of acrylic or methacrylic acid that form solid, insoluble products when mixed with specially prepared ZnO powder. The resulting cement adheres to dental enamel and is also used as a luting agent.
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Polychaeta

A class of marine annelids including sandworms, tube worms, clamworms, and fire worms. It includes also the genus Myxicola infundibulum.
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polychlorované bifenyly

Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.
MSH

a kind of industrial product
CHV

Polychlorinated Biphenyls (PCBs) are a family of more than 200 chemical compounds (congeners) with 1 to 10 chlorine atoms attached to biphenyl and a general structure of C12H10-xClx. PCBs were commercially produced as complex mixtures of congeners at different degrees of chlorination for a variety of applications. Their use was based on their chemical stability, and desirable physical properties. According to WHO, several congeners are now considered to be “dioxin-like” because of their toxicity and certain features of their structure similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin. PCBs are not readily biodegradable, their use declined and was essentially terminated because of environmental concerns. USA stopped producing PCBs in 1977. (NCI)
NCI

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polychlorterfenylové sloučeniny

Compounds consisting of three benzene rings linked to each other in either ortho, meta or para positions and substituted with chlorine atoms.
MSH

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polychondritida recidivující

An acquired disease of unknown etiology, chronic course, and tendency to recur. It is characterized by inflammation and degeneration of cartilage and can result in deformities such as floppy ear and saddle nose. Loss of cartilage in the respiratory tract can lead to respiratory obstruction.
MSH

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polycyklické sloučeniny

Compounds consisting of two or more fused ring structures.
MSH

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polycyklické uhlovodíky

Hydrocarbons consisting of two or more fused ring structures.
MSH

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