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prostaglandin-13,14-reduktasa

(5Z)-(15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta(13)-oxidoreductase. An enzyme active in prostaglandin E and F catabolism. It catalyzes the reduction of the double bond at the 13-14 position of the 15-ketoprostaglandins and uses NADPH as cofactor. EC 1.3.1.48.
MSH

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prostaglandiny

A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
MSH

group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway; extremely potent mediators of a diverse group of physiological processes.
CSP

a kind of hormone
CHV

One of several hormone-like substances made by the body. Different PGs control blood pressure, contraction of smooth muscles, and other processes within tissues where they are made. Certain PGs are being studied as cancer biomarkers.
NCI

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prostaglandiny A

(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid (PGA(1)); (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid (PGA(2)); (5Z,13E,15S,17Z)-15-hydroxy-9-oxoprosta-5,10,13,17-tetraen-1-oic acid (PGA(3)). A group of naturally occurring secondary prostaglandins derived from PGE; PGA(1) and PGA(2) as well as their 19-hydroxy derivatives are found in many organs and tissues.
MSH

a kind of hormone
CHV

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prostaglandiny A syntetické

Analogs or derivatives of prostaglandin A that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGA.
MSH

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prostaglandiny B

Physiologically active prostaglandins found in many tissues and organs. They are potent pressor substances and have many other physiological activities.
MSH

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prostaglandiny D

Physiologically active prostaglandins found in many tissues and organs. They show pressor activity, are mediators of inflammation, and have potential antithrombotic effects.
MSH

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prostaglandiny E

(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
MSH

prostaglandin E2 is the most common and most biologically active of the mammalian prostaglandins; it exhibits most biological activities characteristic of prostaglandins including vasodilation, immune modulatory effects, contraction or relaxation of smooth muscle, inhibition of gastric secretion and sodium resorption inhibition; it has been used extensively as an oxytocic agent and displays a protective effect on the intestinal mucosa; prostaglandin E1 has many similar properties and also inhibits platelet aggregation.
CSP

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prostaglandiny E syntetické

Analogs or derivatives of prostaglandins E that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE.
MSH

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prostaglandiny F

(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
MSH

stable prostaglandin formed from PGH2 or PGE2; stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction in some vessels.
CSP

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prostaglandiny F syntetické

Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.
MSH

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prostaglandiny G

A group of physiologically active prostaglandin endoperoxides. They are precursors in the biosynthesis of prostaglandins and thromboxanes. Most frequently encountered member of this group is the prostaglandin G2.
MSH

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prostaglandiny H

A group of physiologically active prostaglandin endoperoxides. They are precursors in the biosynthesis of prostaglandins and thromboxanes. The most frequently encountered member of this group is the prostaglandin H2.
MSH

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epoprostenol

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
MSH

prostaglandin synthesized by the vascular endothelium; potent inhibitor of platelet aggregation and powerful vasodilator.
CSP

An oral prostacyclin and a metabolite of arachidonic acid with antihypertensive and platelet inhibitory properties. Epoprostenol binds to prostacyclin receptors on platelet surfaces, subsequently activating platelet membrane adenyl cyclase and resulting in increased cAMP levels. The elevated cAMP triggers signal transduction that leads to vasodilations. In addition, this agent also functions as an antagonist of thromboxane A2, thereby resulting in direct vasodilation of pulmonary and systemic arterial vascular beds, and inhibition of platelet aggregation.
NCI

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prostaglandiny syntetické

Compounds obtained by chemical synthesis that are analogs or derivatives of naturally occurring prostaglandins and that have similar activity.
MSH

synthetic or natural chemical compounds which resemble naturally occurring prostaglandins in structure and/or function.
CSP

Any synthetic agent that is chemically identical or similar to any of the naturally occurring prostaglandin subtypes.
NCI

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kyseliny prostanové

2-Octylcyclopentaneheptanoic acids. The family of saturated carbon-20 cyclic fatty acids that represent the parent compounds of the prostaglandins.
MSH

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prostata

A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
MSH

Lobular organ the parenchyma of which consists of glandular acini which communicate with the prostatic part of the urethra. Examples: There is only one prostate.
UWDA

gland in males that surrounds the neck of the bladder and the urethra; it contributes to the seminal fluid, a secretion containing acid phosphatase, citric acid, and proteolytic enzymes that liquefies coagulated semen.
CSP

A gland in the male reproductive system. The prostate surrounds the part of the urethra (the tube that empties the bladder) just below the bladder, and produces a fluid that forms part of the semen.
NCI

Lobular organ the parenchyma of which has as its parts glandular acini which are continuous with the prostatic part of the urethra. Examples: There is only one prostate.
FMA

The walnut shaped accessory sex gland of the male reproductive system. It is located in the pelvis just below the bladder, surrounding the prostatic part of the urethra. The prostate gland secretes a fluid which is part of the semen. (NCI)
NCI

The walnut shaped accessory sex gland of the male reproductive system. It is located in the pelvis just below the bladder, surrounding the prostatic part of the urethra. The prostate gland secretes a fluid which is part of the semen.
NCI

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prostatektomie

Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic – removal through an incision above the pubis and through the urinary bladder; retropubic – as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).
MSH

An operation to remove part or all of the prostate. Radical (or total) prostatectomy is the removal of the entire prostate and some of the tissue around it.
NCI

Surgical removal of part or all of the prostate.
NCI

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prostata – nemoci

Pathological processes involving the PROSTATE or its component tissues.
MSH

deviation from or interruption of the normal structure or function of the prostate.
CSP

The prostate is a gland. It helps make semen, the fluid that contains sperm. The prostate surrounds the tube that carries urine away from the bladder and out of the body. A young man`s prostate is about the size of a walnut. It slowly grows larger with age. If it gets too large, it can cause problems. This is very common after age 50. The older men get, the more likely they are to have prostate trouble.

Some common problems are

  • Prostatitis – an infection, usually caused by bacteria
  • Benign prostatic hyperplasia, or BPH – an enlarged prostate, which may cause dribbling after urination or a need to go often, especially at night
  • Prostate cancer – a common cancer that responds best to treatment when detected early

NIH: National Institute of Diabetes and Digestive and Kidney Diseases


MEDLINEPLUS

A non-neoplastic or neoplastic disorder affecting the prostate gland. Representative examples include prostatitis, benign prostatic hyperplasia, and cancer.
NCI

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prostata – nádory

Tumors or cancer of the PROSTATE.
MSH

new abnormal prostate tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

A benign or malignant tumor involving the prostate gland.
NCI

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prostatitida

Prostatitis: inflammation of the prostate, appreciated clinically as an enlarged, soft or tender prostate. Prostatic secretions contain large numbers of leukocytes.
AIR

Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.
MSH

inflammation of the prostate.
CSP

Inflammation of the prostate gland.
NCI

An infectious or non-infectious inflammatory process affecting the prostate gland.
NCI

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protézy – design

The plan and delineation of prostheses in general or a specific prosthesis.
MSH

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protézy – selhání

Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
MSH

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zubní protetika

A dental specialty concerned with the restoration and maintenance of oral function by the replacement of missing teeth and structures by artificial devices or prostheses.
MSH

The branch of dentistry dealing with the replacement of teeth and related mouth or jaw structures by artificial devices.
NCI

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prostituce

The practice of indulging in sexual relations for money.
MSH

selling or trading of sexual activities for money or other considerations.
CSP

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protaktinium

Protactinium. A radioactive element of the actinide group of metals. It has the atomic symbol Pa, atomic number 91, and atomic weight 231. It decays by alpha-emission.
MSH

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Protamine Sulfate (USP)

A heparin assay is a device used to determine the level of the anticoagulant heparin in the patient`s circulation. These assays are quantitative clotting time procedures using the effect of heparin on activated coagulation factor X (Stuart factor) or procedures based on the neutralization of heparin by protamine sulfate (a protein that neutralizes heparin).
SPN

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protaminy

A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
MSH

group of small (30-50 residues), arginine-rich nucleoproteins found sporadically throughout the phylogenetic kingdom; the USP drug, the sulfate salt, is used as an antidote to heparin.
CSP

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proteasa – inhibitory

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
MSH

any substance or agent which suppresses, prevents or opposes the actions or biosynthesis of proteases.
CSP

A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies of itself (for example, AIDS virus protease inhibitors), and some can prevent cancer cells from spreading.
NCI

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ochranné oděvy

Clothing designed to protect the individual against possible exposure to known hazards.
MSH

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ochranné prostředky

Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
MSH

equipment specifically designed to enhance the safety of procedures, work environments, or other equipment; e.g., seat belts, air bags, radiation shields, noise mufflers, air filtering systems, etc.
CSP

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