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fluoreny

A family of diphenylenemethane derivatives.
MSH

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fluoreskamin

A nonfluorescent reagent for the detection of primary amines, peptides and proteins. The reaction products are highly fluorescent.
MSH

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fluorescenční angiografie

Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
MSH

visualization of a vascular system after intravenous injection of a fluorescein solution; images may be photographed or televised; used especially in studying the retinal and uveal vasculature.
CSP

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fluoresceiny

A family of spiro(isobenzofuran-1(3H),9`-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
MSH

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fluorescence

The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
MSH

absorption of a photon of light followed, after a delay, by emission of a photon of longer wavelength.
CSP

Fluorescence is a luminescence (i.e., optical phenomenon) in cold bodies, in which a molecule absorbs a high-energy photon, and re-emits it as a lower-energy (longer-wavelength) photon. The energy difference between the absorbed and emitted photons ends up as molecular vibrations (heat).
NCI

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fluorescenční polarizace

Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
MSH

measurement of the polarization of fluorescent light from solutions or microscopic specimens; used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
CSP

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fluorescenční protilátková technika

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
MSH

any immunohistochemical method using antibody labeled with a fluorescent dye and frequently examined by fluorescence microscopy.
CSP

An immunological procedure in which the antibodies are coupled with molecules which fluoresce under ultra violet (UV) light. This makes them particularly suitable for detection of specific antigens in tissues or on cells.
NCI

A bioassay in which fluorescent-coupled antibodies or antigens are used to quantify or qualify a biological response to a stimulus.
NCI

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fluorescenční barviva

Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
MSH

dyes that emit light when exposed to light; the wave length of the emitted light is usually longer than that of the incident light; fluorochromes are substances that cause fluorescence in other substances, that is, dyes used to mark or label other compounds with fluorescent tags, and they are used as markers in biochemistry and immunology.
CSP

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fluoridy – otrava

exposure to excessive amounts of fluorine or its compounds; may occur as a result of accidental ingestion of fluoride-containing pesticides, inhalation of dusts or gases containing fluoride, or prolonged ingestion of water containing large amounts of fluorides; characterized by combined osteosclerosis and osteomalacia and mottled enamel of the teeth when exposure occurs during enamel formation.
CSP

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fluoridy

Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
MSH

A form of the element fluorine that helps prevent tooth decay. Fluoride may be naturally present in drinking water or may be added to it. Fluoride may also be put directly on the teeth, as a gel, toothpaste, or a rinse.
NCI

Fluorine ion requiring removal of one electron to return to its elemental state.
NCI

Considered a trace element, fluoride is any combination of elements containing the fluorine atom in the -1 oxidation state (fluoride ion). Due to its reactivity, fluorine is found in nature as fluorine compounds or fluorides. Fluoride inhibits various enzyme systems, erythrocyte glycolysis and binds Ca++, causing anticoagulation and other toxic effects. In addition, fluoride is a mitogen for osteoblasts and stimulates bone formation. (NCI)
NCI

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fluoridy místní

Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.
MSH

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fluor

A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
MSH

nonmetallic, diatomic gas, symbol F, atomic number 9, atomic weight 18.998, that is a trace element and member of the halogen family.
CSP

An element with atomic symbol F, atomic number 9, and atomic weight 19.0.
NCI

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fluor – radioisotopy

Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
MSH

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fluoracetáty

Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall`s Dictionary of Chemistry, 5th ed)
MSH

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fluorokarbonové polymery

dense, inert resin made up of carbon and fluorine, with or without other halogens or hydrogen.
CSP

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fluorokarbony

Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
MSH

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Fluorochromes

A class of dyes when excited by light of certain wavelengths, emit photons and become fluorescent. Fluorescence gives fluorochromes imaging characteristics and are used to label or stain biological structures.
NCI

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floxuridin

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
MSH

antineoplastic antimetabolite; has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
CSP

A drug used in the treatment of cancer. It is a type of antimetabolite.
NCI

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2`-deoxyuridine-5`-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39242&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39242&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C504″ NCI Thesaurus)
PDQ

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2`-deoxyuridine-5`-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)
NCI

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fluorodeoxyuridylát

5-Fluoro-2`-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine.
MSH

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fluoroimunoanalýza

The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.
MSH

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fluorometholon

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
MSH

A synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Fluorometholone exerts its effects by interacting with cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
NCI

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fluorometrie

An analytical method for detecting and measuring FLUORESCENCE in compounds or targets such as cells, proteins, or nucleotides, or targets previously labeled with FLUORESCENCE AGENTS.
MSH

the measurement of fluorescence.
CSP

An analytical method that utilizes ultraviolet light to excite the sample and detects the fluorescence emitted during the return of the sample to its ground state.
NCI

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fluorofotometrie

Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
MSH

Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics (From MSH2001).
NCI

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fluoroskopie

production of an image when x-rays strike a fluorescent screen.
CSP

An x-ray procedure that makes it possible to see internal organs in motion.
NCI

Examination of the tissues and deep structures of the body by x-ray, using the fluoroscope, a device that produces an image when x-rays strike a fluorescent screen.
NCI

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fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
MSH

pyrimidine analog that is an antineoplastic antimetabolite.
CSP

A drug used to treat symptoms of cancer of the colon, breast, stomach, and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite.
NCI

An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2`-deoxyuridine-5`-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), a necessary constituent of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43130&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43130&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C505″ NCI Thesaurus)
PDQ

An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2`-deoxyuridine-5`-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.
NCI

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fluoxetin

The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
MSH

N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine; used in the treatment of depression; action thought to be linked to its inhibition of CNS neuronal uptake of serotonin.
CSP

A drug used to treat depression. It belongs to the family of drugs called antidepressants.
NCI

antidepressant drug sold under the brand name Prozac
CHV

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fluoxymesteron

An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women.
MSH

A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=494707&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=494707&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C507″ NCI Thesaurus)
PDQ

A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. (NCI04)
NCI

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flupenthixol

A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)
MSH

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flufenazin

A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.
MSH

2-trifluoromethyl derivative of perphenazine, used in treatment of psychoses.
CSP

A phenothiazine with antipsychotic activity. Fluphenazine exerts its actions by blocking postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia.
NCI

A drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type of antipsychotic.
NCI

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fluprednisolon

A synthetic glucocorticoid with anti-inflammatory properties.
MSH

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