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thiethylperazin

A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
MSH

A piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.
NCI

A drug used to prevent or reduce nausea and vomiting. It belongs to the families of drugs called antiemetics and phenothiazines.
NCI

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stehno

A part of the lower limb, located between hip and knee. (NCI)
NCI

A part of the lower limb, located between hip and knee.
NCI

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thimerosal

An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.
MSH

An organomercurial compound and derivative of thiosalicyclic acid with antibacterial and antifungal properties. Although the mechanism of action has not been fully elucidated, thimerosal inhibits sulfhydryl-containing active site of various enzymes and binds to sulfhydryl compounds, such as glutathione, cysteine, and SH groups of proteins. In addition, thimerosal activates the InsP3 calcium channel on endoplasmic reticular membrane, thereby triggering the release of calcium from intracellular stores resulting in a calcium-induced calcium-influx of extracellular calcium. Consequently, thimerosal may induce or inhibit cellular functions dependent on calcium signaling.
NCI

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myšlení

mental activity, not predominantly perceptual, by which one apprehends some aspect of an object or situation based on past learning and experience.
CSP

Mental activity, not predominantly perceptual, by which one apprehends some aspect of an object or situation based on past learning and experience. (On-line Medical Dictionary)
NCI

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hubenost

A state of insufficient flesh on the body usually defined as having a body weight less than skeletal and physical standards. Depending on age, sex, and genetic background, a BODY MASS INDEX of less than 18.5 is considered as underweight.
MSH

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thiotepa

A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
MSH

alkylating agent used as an antineoplastic in the treatment of carcinoma of the breast, ovary, and bladder, malignant infusions and lymphomas.
CSP

An anticancer drug that belongs to the family of drugs called alkylating agents.
NCI

A synthetic alkylating agent. Related to nitrogen mustard, thiotepa alkylates and crosslinks DNA, resulting in the inhibition of DNA replication. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42933&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42933&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C875″ NCI Thesaurus)
PDQ

A synthetic alkylating agent. Related to nitrogen mustard, thiotepa alkylates and crosslinks DNA, resulting in the inhibition of DNA replication. (NCI04)
NCI

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thioacetamid

A crystalline compound used as a laboratory reagent in place of HYDROGEN SULFIDE. It is a potent hepatocarcinogen.
MSH

A synthetic, colorless crystalline solid that is soluble in water and ethanol. Thioacetamide is currently only used as a replacement for hydrogen sulfide in qualitative analysis. When heated to decomposition, it emits toxic fumes of nitrogen oxides and sulfur oxides. The primary routes of potential human exposure to thioacetamide are inhalation and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
NCI

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thioamidy

Organic compounds containing the radical -CSNH2.
MSH

compounds of the type R-(C=S)-N=.
CSP

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Thiobacillus

A genus of gram-negative, rod-shaped bacteria that derives energy from the oxidation of one or more reduced sulfur compounds. Many former species have been reclassified to other classes of PROTEOBACTERIA.
MSH

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Acidithiobacillus thiooxidans

A strictly autotrophic species of bacteria that oxidizes sulfur and thiosulfate to sulfuric acid. It was formerly called Thiobacillus thiooxidans.
MSH

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thiobarbituráty

Compounds in which one or more of the ketone groups on the pyrimidine ring of barbituric acid are replaced by thione groups.
MSH

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thiokarbamáty

Carbamates in which the -CO- group has been replaced by a -CS- group.
MSH

carbamates in which either or both O atoms are replaced by S.
CSP

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thiocholin

A mercaptocholine used as a reagent for the determination of CHOLINESTERASES. It also serves as a highly selective nerve stain.
MSH

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thiokyanatany

Organic derivatives of thiocyanic acid which contain the general formula R-SCN.
MSH

compounds of the type R-S=C=N.
CSP

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Thioethers

any compound of the type R-S-R.
CSP

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thiogalaktosidy

Galactosides in which the oxygen atom linking the sugar and aglycone is replaced by a sulfur atom.
MSH

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thioglykoláty

Organic esters of thioglycolic acid (HS-CH2COOH).
MSH

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thioguanin

An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
MSH

thioguanine is USP.
CSP

An anticancer drug that belongs to the family of drugs called antimetabolites.
NCI

a kind of cancer treatment drug
CHV

A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43669&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C876″ NCI Thesaurus)
PDQ

A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)
NCI

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thioinosin

Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)
MSH

A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de novo purine synthesis and perturbs the pool of nucleotides necessary for DNA replication. As a result, this agent inhibits DNA synthesis, blocks cellular proliferation and induces apoptosis.
NCI

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thiony

compounds of the type R-(C=S)-R.
CSP

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thionukleosidy

Nucleosides in which the base moiety is substituted with one or more sulfur atoms.
MSH

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thionukleotidy

Nucleotides in which the base moiety is substituted with one or more sulfur atoms.
MSH

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thiopental

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.
MSH

ultra-short acting barbiturate used as an anesthetic, anticonvulsant, and narcoanalysis.
CSP

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thiofanát

Nematocide used in livestock; also has fungicidal properties.
MSH

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thioredoxiny

family of small (13 kD) electron carrier proteins which mediate a number of reactions, including the conversion of ribonucleotides (RNA precursors) to deoxyribonucleotides (DNA precursors) by ribonucleotide reductase.
CSP

Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.
MSH

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thioredoxin-disulfidreduktasa

A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 1.6.4.5
MSH

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thioridazin

A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
MSH

phenothiazine compound having antipsychotic and sedative effects, used in treatment of schizophrenia and acute psychotic episodes, for relief of anxiety, agitiation and depression in mood disorders, and for treatment of disruptive behavior disorders in children.
CSP

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thiorfan

A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
MSH

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thiostrepton

One of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.
MSH

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thiosulfátsulfurtransferasa

An enzyme that catalyzes the transfer of the planetary sulfur atom of thiosulfate ion to cyanide ion to form thiocyanate ion. EC 2.8.1.1.
MSH

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