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thrombin

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
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thrombangiitis obliterans

A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
MSH

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trombocytémie esenciální

clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
CSP

An increased number of thrombocytes (platelets) in the blood, without a known cause.
NCI

A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
MSH

A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage. The cause is unknown. Median survival times of 10-15 years are commonly reported. (WHO, 2008)
NCI

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trombocytopenie

A subnormal level of BLOOD PLATELETS.
MSH

decrease in the number of blood platelets.
CSP

A condition in which there is a lower-than-normal number of platelets in the blood. It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues.
NCI

A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.
NCI

A condition in which there is an abnormally small number of platelets in the circulating blood.
NCI

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tromboembolie

Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.
MSH

obstruction of a blood vessel with thrombotic material carried by the blood stream from the site of origin to plug another vessel.
CSP

A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream.
NCI

Occlusion of the lumen of a vessel by a thrombus that has migrated from a distal site via the blood stream.
NCI

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trombolytická terapie

Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
MSH

use of infusions of fibrinolytic agents to destroy or dissolve thrombi in blood vessels or in bypass grafts.
CSP

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tromboflebitida

Inflammation of a vein associated with a blood clot (THROMBUS).
MSH

Inflammation of a vein that occurs when a blood clot forms.
NCI

swelling of a vein caused by a blood clot
CHV

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thromboplastin

Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.
MSH

coagulation factor important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of blood coagulation; derived from several sources in the body including brain and lungs.
CSP

Human coagulation factor-III protein (295 aa, 33 kDa precursor) is encoded by the human coagulation factor III (thromboplastin, tissue factor) (F3) gene. The factor is a glycoprotein/phospholipid, which functions as a potent high-affinity transmembrane receptor/cofactor for coagulation factor VII. The protein also plays an important role in blood coagulation.
NCI

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thrombopoetin

A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
MSH

A substance made by the body that helps make blood cells, especially platelets. A form of TPO made in the laboratory is called recombinant human TPO and rHu TPO. TPO is being studied as a way to increase the number of platelets in cancer patients receiving chemotherapy.
NCI

a kind of hormone
CHV

Thrombopoietin is a lineage-restricted, glycoprotein growth factor ligand for the MPL receptor with selective action on megakaryopoiesis and platelet production. THPO has little direct effect on erythroid progenitor cells but may enhance erythropoiesis indirectly by preventing early erythroid progenitor cells from undergoing apoptotic cell death. (from OMIM 600044 and NCI)
NCI

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trombóza

Formation and development of a thrombus or blood clot in the blood vessel.
MSH

formation, development, or presence of a thrombus.
CSP

The formation or presence of a thrombus (blood clot) inside a blood vessel.
NCI

obstruction of a blood vessel by a blood clot
CHV

Formation of a blood clot in the lumen of a vessel. Causes include coagulation disorders and vascular endothelial injury.
NCI

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thromboxan A2

An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
MSH

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thromboxan B2

A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).
MSH

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thromboxan-A synthasa

An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane A2. EC 5.3.99.5.
MSH

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thromboxany

Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.
MSH

physiologically active compounds found in many organs of the body, formed in vivo from the prostaglandin endoperoxides and causing platelet aggregation, contraction of arteries, and other biological effects; important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.
CSP

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thulium

Thulium. An element of the rare earth family of metals. It has the atomic symbol Tm, atomic number 69, and atomic weight 168.93.
MSH

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palec ruky

The thick and short hand digit which is next to the index finger in humans.
NCI

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thymektomie

Surgical removal of the thymus gland. (Dorland, 28th ed)
MSH

surgical removal of the thymus gland.
CSP

Surgical removal of part or all of the thymus gland.
NCI

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1,2-dipalmitoylfosfatidylcholin

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.
MSH

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enzym větvící alfa-glukan v poloze 1,4

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.
MSH

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kyselina 1-karboxyglutamová

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.
MSH

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1-methyl-3-isobutylxanthin

A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
MSH

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1-methyl-4-fenyl-1,2,3,6-tetrahydropyridin

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
MSH

1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, a toxic contaminant found in the abused drug methylenedioxymethamphetamine (“ecstasy”) which causes Parkinsonlike symptoms.
CSP

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1-methyl-4-fenylpyridinium

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
MSH

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1-naftylamin

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.
MSH

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1-naftylisothiokyanát

A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.
MSH

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1-sarkosin-8-isoleucin angiotensin II

An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.
MSH

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11-hydroxykortikosteroidy

A group of corticosteroids bearing a hydroxy group at the 11-position.
MSH

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16,16-dimethylprostaglandin E2

A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.
MSH

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17-hydroxykortikosteroidy

A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
MSH

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17-hydroxysteroiddehydrogenasy

A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.
MSH

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