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Ticlopidine Hydrochloride

The hydrochloride salt form of ticlopidine, a thienopyridine derivative with anticoagulant property. Ticlopidine hydrochloride irreversibly inhibits adenosine-diphosphate (ADP)-induced platelet-fibrinogen binding by binding to the glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. Inhibition of the receptor activation causes the inhibition of adenylyl cyclase, results in decreased levels of cyclic adenosine monophosphate and thereby interferes with platelet membrane function and subsequent, platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.
NCI

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kyselina 6-aminokapronová

An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
MSH

A synthetic lysine derivative with antifibrinolytic activity. Aminocaproic acid competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots as well as fibrinogen and other plasma proteins including the procoagulant factors V and VIII. Aminocaproic acid competitively reduces the conversion of plasminogen to plasmin by plasminogen activators. It directly inhibits proteolytic activity of plasmin, but higher doses are required than are needed to reduce plasmin formation. Aminocaproic acid is used in the treatment of hemorrhage and prophylactically against hemorrhage, including hyperfibrinolysis-induced hemorrhage and postsurgical hemorrhage.
NCI

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6-aminonikotinamid

A vitamin antagonist which has teratogenic effects.
MSH

A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04)
NCI

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6-ketoprostaglandin F1 alfa

The physiologically active and stable hydrolysis product of EPOPROSTENOL. Found in nearly all mammalian tissue.
MSH

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6-merkaptopurin

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
MSH

A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites.
NCI

A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5`-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43436&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43436&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C195″ NCI Thesaurus)
PDQ

A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5`-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04)
NCI

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7,8-dihydro-7,8-dihydroxybenzo(a)pyren 9,10-oxid

7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
MSH

A benzopyrene derivative with carcinogenic and mutagenic activity. (MeSH)
NCI

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7-alkoxykumarin-O-dealkylasa

A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.
MSH

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7S Collagen

A stable peptide fragment originating from the N-terminal domain of collagen type IV.
MSH

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kyselina 8,11,14-eikosatrienová

A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.
MSH

A polyunsaturated long-chain fatty acid with a 20-carbon backbone and 3 double bonds, originating from the 6th, 9th and 12th positions from the methyl end, with all bonds in the cis- configuration.
NCI

Polyunsaturated fatty acid with 20 carbons and 3 double bonds at the 6th, 9th and 12th carbons from the methyl end.
NCI

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8-bromcyklický adenosinmonofosfát

A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.
MSH

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oxychinolin

An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
MSH

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9,10-dimethyl-1,2-benzanthracen

7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
MSH

a cancer causing substance found in tobacco smoke
CHV

polycyclic aromatic hydrocarbon that is a potent carcinogen.
CSP

A polycyclic aromatic hydrocarbon produced during combustion of fuels exhibiting carcinogenic activity. In addition, dimethylbenzanthracene is found in tobacco smoke. (NCI)
NCI

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A-zenuwvezels

a kind of nerve fiber
CHV

Type A fibers are the myelinated fibers ranging from 1-22 um in diameter with NEURAL CONDUCTION rates of 5-120 m/sec. They are the typical myelinated fibers of spinal nerves. Type A fibers are further subdivided into alpha, beta, gamma, and delta fibers.
MSH

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gama-globin A

A type of gamma-globin encoded by the A gamma globin gene on CHROMOSOME 11.
MSH

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kalcimycin

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
MSH

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DNA – A-forma

An isoform of DNA that occurs in an environment rich in SODIUM and POTASSIUM ions. It is a right-handed helix with 11 base pairs per turn, a pitch of 0.256 nm per base pair and a helical diameter of 2.3 nm.
MSH

A-DNA is a shorter and wider helix than B-DNA. Most RNA and RNA-DNA duplex are in this form. While deep, narrow major groove is not easily accessible to proteins but wide, shallow minor groove is accessible to proteins but with lower information content than major groove. A-DNA is the favored conformation at low water concentrations. Base pairs are tilted to helix axis and displaced from axis and sugar pucker is C3`-endo (in RNA 2`-OH inhibits C2`-endo conformation). When examined from the top of the helix, there is a large hole in the middle, the sugar phosphate backbone is at the edge of the helix, and the bases are displaced towards the edge.
NCI

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abat

An organothiophosphate insecticide.
MSH

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jatka

Places where animals are slaughtered and dressed for market.
MSH

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úrazy – zkrácená stupnice

Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).
MSH

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zkratky

A shortened form of a word or phrase.
NCI

Works consisting of lists of shortened forms of written words or phrases used for brevity. Acronyms are included here.
MSH

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břicho

That portion of the body that lies between the THORAX and the PELVIS.
MSH

Subdivision of trunk, which is demarcated from the thorax internally by the inferior surface of the sternocostal part of the diaphragm and externally by the costal margin, from the pelvis by the plane of the superior pelvic aperture and from the lower limbs by the inguinal folds; together with the thorax, pelvis, and perineum, it constitutes the trunk. Examples: There is only one abdomen.
UWDA

portion of the body that lies between the thorax and the pelvis.
CSP

Having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs.
NCI

Subdivision of trunk proper which is demarcated from the thorax internally by the inferior surface of the sternocostal part of the diaphragm and externally by the costal margin, from the back of abdomen by the external surface of the posterior abdominal wall, from the perineum by the superior surface of the urogenital diaphragm and from the lower limbs by the inguinal folds; together with the thorax, and perineum, it constitutes the trunk proper. Examples: There is only one abdomen.
FMA

Of, or related to, the abdomen.
NCI

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akutní bolest břicha

A clinical syndrome with acute abdominal pain that is severe, localized, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.
MSH

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Břišní křeče

An involuntary muscular contraction involving a muscle of the abdomen or of a hollow organ within the abdomen.
NCI

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ABDOMENAREN BOLUMEN ALDAKETA/ABDOMEN HAUNDITZEA

Swelling of the abdomen resulting from excessive food intake, malnutrition, liver disease, primary abdominal tumors, and tumors metastatic to the abdominal cavity.
NCI

A disorder characterized by swelling of the abdomen.
NCI

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břicho – poranění

General or unspecified injuries involving organs in the abdominal cavity.
MSH

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břicho – nádory

new abnormal abdominal tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
CSP

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bolesti břicha

Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue injuries, or diseases.
MSH

Your abdomen extends from below your chest to your groin. Some people call it the stomach, but your abdomen contains many other important organs. Pain in the abdomen can come from any one of them. The pain may start somewhere else, such as your chest. Severe pain doesn`t always mean a serious problem. Nor does mild pain mean a problem is not serious.

Call your healthcare provider if mild pain lasts a week or more or if you have pain with other symptoms. Get medical help immediately if

  • You have abdominal pain that is sudden and sharp
  • You also have pain in your chest, neck or shoulder
  • You`re vomiting blood or have blood in your stool
  • Your abdomen is stiff, hard and tender to touch
  • You can`t move your bowels, especially if you`re also vomiting


MEDLINEPLUS

A disorder characterized by a sensation of marked discomfort in the abdominal region.
NCI

Painful sensation in the abdominal region.
NCI

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břišní svaly

Muscles forming the ABDOMINAL WALL including RECTUS ABDOMINIS, external and internal oblique muscles, transversus abdominis, and quadratus abdominis. (from Stedman, 25th ed)
MSH

Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis.
FMA

Any of the muscles of the abdomen that comprise the abdominal wall; these muscles include the rectus abdominis, the external and internal oblique muscles, the transversus abdominis, and the quadratus abdominis.
NCI

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nervus abducens

The 6th cranial nerve. The abducens nerve originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye. Damage to the nerve or its nucleus disrupts horizontal eye movement control.
MSH

A cranial nerve that supplies motor impulses to the lateral rectus muscle of the eye.
NCI

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virus Abelsonovy myší leukémie

replication defective strain of murine leukemia virus capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with Maloney, Friend or Rauscher murine leukemia virus.
CSP

A replication-defective strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with FRIEND MURINE LEUKEMIA VIRUS; MOLONEY MURINE LEUKEMIA VIRUS; or RAUSCHER VIRUS.
MSH

A retrovirus that is associated with leukemia and induces in vitro transformation of certain mouse cells.
NCI

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