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aminoacetonitrily

Cyanomethylamine.
MSH

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renální aminoacidurie

inborn genetic mutations causing impairment of renal tubular transport of amino acids.
CSP

A group of inherited kidney disorders characterized by the abnormally elevated levels of AMINO ACIDS in URINE. Genetic mutations of transport proteins result in the defective reabsorption of free amino acids at the PROXIMAL RENAL TUBULES. Renal aminoaciduria are classified by the specific amino acid or acids involved.
MSH

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aminoakridiny

Acridines which are substituted in any position by one or more amino groups or substituted amino groups.
MSH

highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA; it is also used as an intracellular pH indicator.
CSP

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kyseliny aminobenzoové

BENZOIC ACID substituted with an amino group. They can either be mono-, di-, or tri- substituted. Para-aminobenzoic acid (see 4-AMINOBENZOIC ACID) is considered a member of the vitamin b complex.
MSH

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aminobifenylové sloučeniny

Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.
MSH

nitrogen substituted aromatic amine formerly used in dyemaking; now used to induce cancer in laboratory animals.
CSP

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4-aminobutyráttransaminasa

An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.
MSH

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kyseliny aminomáselné

Aliphatic four carbon acids substituted in any position(s) with amino group(s). They are found in most living things. The best known is GAMMA-AMINOBUTYRIC ACID.
MSH

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kyseliny aminokapronové

A group of compounds that are derivatives of aminohexanoic acids.
MSH

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kyselina aminoethylfosfonová

An organophosphorus compound isolated from human and animal tissues.
MSH

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aminoglutethimid

An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
MSH

USP lists as an antineoplastic and an “adrenocortical suppressant.”
CSP

An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors that need sex hormones to grow.
NCI

A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production.
NCI

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aminoglykosidy

Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.
MSH

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kyseliny aminohipurové

A group of glycine amides of aminobenzoic acids.
MSH

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aminoimidazolkarboxamid

An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.
MSH

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kyseliny aminoisomáselné

A group of compounds that are derivatives of the amino acid 2-amino-2-methylpropanoic acid.
MSH

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kyselina aminolevulová

A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
MSH

The active ingredient in a drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent.
NCI

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C234″ NCI Thesaurus)
PDQ

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. (NCI04)
NCI

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porfobilinogensynthasa

An enzyme that catalyzes the formation of porphobilinogen from two molecules of 5-aminolevulinic acid. EC 4.2.1.24.
MSH

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5-aminolevulátsynthetasa

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
MSH

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kyselina aminooxyoctová

A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
MSH

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aminopeptidasy

A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11.
MSH

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aminofenoly

Phenols substituted in any position by an amino group.
MSH

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aminofylin

A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It`s most common use is in bronchial asthma, but it has been investigated for several other applications.
MSH

drug combination that contains theophylline and ethylenediamine; its most common use is in bronchial asthma, but it has been investigated for several other applications.
CSP

A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.
NCI

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aminopropionitril

3-Aminopropanenitrile. Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.
MSH

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aminopterin

A folic acid derivative used as a rodenticide that has been shown to be teratogenic.
MSH

folic acid derivative used as a rodenticide that has been shown to be teratogenic.
CSP

An anticancer drug that belongs to the family of drugs called antimetabolites.
NCI

A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39141&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39141&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C235″ NCI Thesaurus)
PDQ

A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)
NCI

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aminopyridiny

Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.
MSH

pyridines substituted in any position with an amino group; may be hydrogenated, but must retain at least one double bond.
CSP

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aminopyrin

A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.
MSH

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aminochinoliny

Quinolines substituted in any position by one or more amino groups.
MSH

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aminorex

An amphetamine-like anorectic agent. It may cause pulmonary hypertension.
MSH

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kyseliny aminosalicylové

A group of 2-hydroxybenzoic acids that can be substituted by amino groups at any of the 3-, 4-, 5-, or 6-positions.
MSH

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transaminasy

A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.
MSH

Transaminases are a sub-subclass of mostly pyridoxal phosphate-dependent transferase enzymes that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Mediating conversion of major intermediate metabolites and reversible transamination, Transaminases are often involved in cellular nitrogen metabolism, amino acid metabolism, gluconeogenesis and in the urea and tricarboxylic acid cycles.
NCI

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amiodaron

An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance.
MSH

2-butyl-3-(3,5-diiodo-4-beta diethylaminoethoxybenzoyl) benzofuran; coronary vasodilator used as an antiarrhythmic; severe risk of pulmonary and hepatic toxicity via disruption of lysosomal function; also has amphiphilic phototoxin properties.
CSP

An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.
NCI

a drug used to treat angina and arrythmia
CHV

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