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benzazepiny

Compounds with BENZENE fused to AZEPINES.
MSH

bicyclic structure consisting of fused benzene and azepine rings; many compounds with this structure react with biogenicamine receptors, and so are psychotropic and neurotropic.
CSP

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benzbromaron

Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.
MSH

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benzen

Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
MSH

toxic, volatile, flammable liquid hydrocarbon biproduct of coal distillation; structure consists of a closed hexagonal chain of six carbon atoms, each attached to a hydrogen atom and attached to each other by alternating single and double (resonating) bonds; in benzene derivatives, one or more of the hydrogen atoms are replaced by other atoms or radicals.
CSP

A chemical that is used widely by the chemical industry, and is also found in tobacco smoke, vehicle emissions, and gasoline fumes. Exposure to benzene may increase the risk of developing leukemia.
NCI

A clear, colorless, highly flammable and volatile, liquid aromatic hydrocarbon with a gasoline-like odor. Benzene is found in crude oils and as a by-product of oil-refining processes. In industry benzene is used as a solvent, as a chemical intermediate, and is used in the synthesis of numerous chemicals. Exposure to this substance causes neurological symptoms and affects the bone marrow causing aplastic anemia, excessive bleeding and damage to the immune system. Benzene is a known human carcinogen and is linked to an increased risk of developing lymphatic and hematopoietic cancers, acute myelogenous leukemia, as well as chronic lymphocytic leukemia. (NCI05)
NCI

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lindan

An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.
MSH

gamma isomer of benzene hexachloride, a carcinogenic insecticide more potent than DDT (chlorophenothane); it is used to kill lice and mites, applied topically to the skin.
CSP

The gamma-isomer of benzene hexachloride, a colorless to white colored, synthetic, crystalline solid with a slight musty odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Lindane is used as an insecticide for hardwood logs, lumber, and crops. Lindane also has topical pediculicide and scabicide activities probably due to its neurotoxic effects. Inhalation exposure to this substance causes severe irritation of the nose and throat, causes anemia, and affects the liver, nervous, cardiovascular, and immune system. Lindane is reasonably anticipated to be a human carcinogen.
NCI

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benzensulfonáty

Organic salts and esters of benzenesulfonic acid.
MSH

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benzethonium

Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
MSH

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benzhydrylové sloučeniny

Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.
MSH

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benzidine

A grayish-red, yellowish or white colored, very toxic, crystalline aromatic amine that darkens when exposed to air and light. Benzidine has been widely used for the detection of blood and as a reagent in the manufacture of dyes. Ingestion of benzidine causes cyanosis, headache, mental confusion, nausea and vomiting. Its use is now limited because of strong association between exposure to benzidine and an increased risk of bladder cancer in humans. (NCI05)
NCI

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benzidiny

Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.
MSH

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benzimidazoly

Compounds with a BENZENE fused to IMIDAZOLES.
MSH

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benzo(a)pyren

A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
MSH

A crystalline, aromatic hydrocarbon consisting of five fused benzene rings and formed during the incomplete combustion of organic matter. 3,4-Benzpyrene is primarily found in gasoline and diesel exhaust, cigarette smoke, coal tar and coal tar pitch, charcoal-broiled foods and certain other foods, amino acids, fatty acids and carbohydrate pyrolysis products, soot smoke, creosote oil, petroleum asphalt and shale oils. This substance is used only for research purposes. 3,4-Benzpyrene is reasonably anticipated to be a human carcinogen. (NCI05)
NCI

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benzoáty

Salts and esters of BENZOIC ACID that possess antibacterial and antifungal properties. They are used as preservatives in pharmaceuticals, cosmetics, and foods.
MSH

benzoic acid (C6H5COOH), and its salts, esters and derivatives; many possess antibacterial and antifungal properties and are used as preservatives in pharmaceuticals, cosmetics, and foods.
CSP

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benzokain

A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
MSH

An ester of paraaminobenzoic acid, lacking the terminal diethylamino group of procaine, with anesthetic activity. Benzocaine binds to the sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited, thereby blocking the initiation and conduction of nerve impulses.
NCI

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benzodiazepiny

A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.
MSH

bicyclic structure consisting of fused benzene and diazepine rings; many compounds with this structure have psychotropic and neurotropic properties, and are used as sedatives, anticonvulsants, muscle relaxants, and in related applications.
CSP

a drug used to relieve nervousness, tension and anxiety
CHV

Drugs from this chemical class are used for their central nervous system depressant properties including sedation, facilitation of sleep, seizure control, general anesthesia, anxiolytic, amnestic, and for detoxification from similar (cross tolerant) drugs
NCI

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benzoflavony

Organic compounds containing a benzene ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of nucleic acids to benzopyrenes and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.
MSH

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benzofurany

Compounds that contain a BENZENE ring fused to a furan ring.
MSH

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benzoin

A white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide and used in organic syntheses. This should not be confused with benzoin gum from STYRAX.
MSH

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benzolamid

Selective renal carbonic anhydrase inhibitor. It may also be of use in certain cases of respiratory failure.
MSH

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benzomorfany

Morphine derivatives of the methanobenzazocine family that act as potent analgesics.
MSH

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benzofenoneidum

An aniline dye used as a disinfectant and an antiseptic agent. It is weakly fluorescing and binds specifically to certain proteins.
MSH

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benzopyrany

compounds with a core of fused benzo-pyran rings.
CSP

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benzopyrenhydroxylasa

A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.
MSH

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benzopyreny

A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
MSH

procarcinogens containing an anthracene ring with a naphthalene ring attached to it; found as a product of incomplete combustion and in coal tar.
CSP

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benzothiadiaziny

Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.
MSH

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benzoylperoxid

A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.
MSH

A peroxide with antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory activity. Upon topical application, benzoyl peroxide decomposes to release oxygen which is lethal to the bacteria Proprionibacterium acnes. Due to its irritant effect, benzoyl peroxide increases turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of comedones. Benzoyl peroxide is used in the treatment of acne vulgaris.
NCI

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benzoylarginin nitroanilid

A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product.
MSH

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benzoylarginin-2-naftylamid

An enzyme substrate which permits the measurement of peptide hydrolase activity, e.g. trypsin and thrombin. The enzymes liberate 2-naphthylamine, which is measured by colorimetric procedures.
MSH

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benzoylcholin

The benzoic acid ester of choline.
MSH

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benzfetamin

A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
MSH

A sympathomimetic amine related to the synthetic agent amphetamine with central nervous system (CNS) stimulating and anorexic properties. Benzphetamine stimulates the release of certain catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. The increase in synaptic concentrations of these catecholamines causes behavioral changes including euphoria, an increase in mental alertness and excitement, and suppresses appetite.
NCI

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benztropin

A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.
MSH

centrally active muscarinic antagonist that has been used in the symptomatic treatment of Parkinson disease; also inhibits the uptake of dopamine.
CSP

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