Additional pages

kloprostenol

A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle.
MSH

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klorazepát dvojdraselný

A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.
MSH

A benzodiazepine with anxiolytic, sedative, hypnotic, and anticonvulsant properties. Clorazepate dipotassium exerts its effect by de-activating the nervous system through potentiation of the inhibitory effect of gamma-aminobutyric acid (GABA) on the GABA-A receptors by binding to a site that is distinct from the GABA binding site. Its inhibitory effect is caused by an increase in GABA-mediated chloride channel opening events, leading to hyperpolarization and synaptic inhibition.
NCI

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klorgylin

An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
MSH

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uzávěrový objem

The lung volume at which the dependent lung zones cease to ventilate presumably as a result of airway closure.
MSH

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mikrobiální kolagenasa

A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
MSH

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Clostridium

genus of motile or nonmotile gram positive bacteria of the family Clostridiaceae; many species have been identified with some being pathogenic, occurring in water, soil, and in the intestinal tract of humans and lower animals.
CSP

A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
MSH

A genus of gram-positive, obligate anaerobic bacteria in the Firmicutes phylum capable of producing endospores.
NCI

Any bacteria that is not assigned to the species level but can be assigned to the Clostridium genus level.
NCI

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Clostridium botulinum

etiologic agent of botulism in humans and waterfowl; produces a powerful exotoxin.
CSP

A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.
MSH

Any bacterial organism that can be assigned to the species Clostridium putrificum.
NCI

A species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Firmicutes. This species is indole negative, ferments glucose but not mannose and does not reduce nitrate. C. putrificum is considered pathogenic and may cause post-operative tetanus.
NCI

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Clostridium – infekce

infections with bacteria of the genus Clostridium.
CSP

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Clostridium perfringens

The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.
MSH

Any bacterial organism that can be assigned to the species Clostridium perfringens.
NCI

A species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Proteobacteria. This species is motile, hydrolyzes gelatin, produces enterotoxin, is beta-hemolytic and catalase negative. C. perfringens is a food borne pathogen, being the causative agent of pig-bel syndrome and gas gangrene.
NCI

most common etiologic agent of gas gangrene; differentiable into several distinct types based on the distribution of twelve different toxins.
CSP

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Clostridium tetani

The cause of TETANUS in humans and domestic animals. It is a common inhabitant of human and horse intestines as well as soil. Two components make up its potent exotoxin activity, a neurotoxin and a hemolytic toxin.
MSH

Any bacterial organism that can be assigned to the species Clostridium tetani.
NCI

A species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Firmicutes. This species is motile by peritrichous flagella, indole and lipase positive, lecithinase negative, hydrolyzes gelatin, ferments inositol and does not ferment glucose or maltose. C. tetani may colonize the intestinal tract of humans and is pathogenic, being the causative agent of Tetanus infection.
NCI

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koagulum – retrakce

Retraction of a clot resulting from contraction of PLATELET pseudopods attached to FIBRIN strands. The retraction is dependent on the contractile protein thrombosthenin. Clot retraction is used as a measure of platelet function.
MSH

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odívání

A covering designed to be worn on the body.
NCI

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klotrimazol

An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
MSH

A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39116&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39116&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C381″ NCI Thesaurus)
PDQ

A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis.
NCI

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Melanoom, Cloudman S91

A transplantable melanoma that arose spontaneously in a mouse of DBA strain, and which grows and metastasizes in mice of related strains. (dictionarybarn.com)
NCI

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kloxacilin

A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
MSH

A semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.
NCI

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klozapin

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
MSH

tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent; binds several types of central nervous system receptors, and displays a unique pharmacological profile; it is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype, and also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity; agranulocytosis is a major adverse effect associated with administration of this agent.
CSP

a drug used to treat schizophrenia
CHV

A synthetic dibenzo-diazepine derivative, atypical antipsychotic Clozapine blocks several neurotransmitter receptors in the brain (dopamine type 4, serotonin type 2, norepinephrine, acetylcholine, and histamine receptors). Unlike traditional antipsychotic agents, it weakly blocks dopamine type 2 receptors. It relieves schizophrenic symptoms (hallucinations, delusions, dementia). (NCI04)
NCI

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Paličkovité prsty

An enlargement of the tips of the fingers or toes and a change in the angle where the nails emerge. It occurs when the amount of soft tissue beneath the nail beds increases. It may be idiopathic, hereditary, or associated with a wide range of diseases, including cardiopulmonary disorders and malignant neoplasms.
NCI

An abnormal enlargement of the terminal phalanges accompanied by increased length-wise curvature of the nails, giving the digits a club-like appearance. Clubbing has been noted with a wide variety of conditions, including pulmonary and cardiac diseases, liver disorders, and disorders of the gastrointestinal tract.
NCI

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pes equinovarus

A deformed foot in which the foot is plantarflexed, inverted and adducted.
MSH

The most common congenital deformation of the foot, occurring in 1 of 1,000 live births. The most common form is talipes equinovarus, where the deformed foot is turned downward and inward sharply.
NCI

a deformity of the foot which occurs at birth in which one or both feet are twisted
CHV

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analýza shluková

A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
MSH

Methods for grouping objects into subsets such that those within each cluster are more closely related to one another than objects assigned to different clusters.
NCI

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HORTONEN ZEFALEA

A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
MSH

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koagulancia

Agents that cause clotting.
MSH

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koagulasa

Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.
MSH

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uhlí

A natural fuel formed by partial decomposition of vegetable matter under certain environmental conditions.
MSH

natural fossil fuel formed by partial decomposition of vegetable matter under certain environmental conditions.
CSP

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dehet uhelný

A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
MSH

A dark brown or black thick liquid obtained by roasting pine wood or formed as a by-product in the production of coke. Coal tar is a complex mixture of organic substances, including benzene, phenols, sulfur, aniline, toluene, xylene, naphthalene, anthracene and phenanthrene. This substance is used to treat certain skin diseases, especially psoriasis, and is used in the synthesis of dyes, drugs, explosives, flavorings, perfumes, preservatives, synthetic resins, paints and stains. Coal tar exposure leads to an increased risk of developing cancer of skin, lung, bladder, kidney and digestive tract as well as leukemia. It is known to be a human carcinogen. (NCI05)
NCI

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kobalt

A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
MSH

trace element that is a component of vitamin B12; atomic symbol Co, atomic number 27, and atomic weight 58.93.
CSP

An element with atomic symbol Co, atomic number 27, and atomic weight 58.93.
NCI

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kobalt – isotopy

Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.
MSH

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kobalt – radioisotopy

Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.
MSH

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kobamidy

biologically active form of vitamin B12, in which the cyanide counterion has been replaced by an adenine nucleoside.
CSP

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kobří neurotoxiny

Toxins, contained in cobra (Naja) venom that block cholinergic receptors; two specific proteins have been described, the small (short, Type I) and the large (long, Type II) which also exist in other Elapid venoms.
MSH

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kobří jedy

Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.
MSH

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