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dihydromorfin

A semisynthetic analgesic used in the study of narcotic receptors. It has abuse potential.
MSH

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dihydromorfinon

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
MSH

The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3`,5`-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.
NCI

A drug used to relieve pain.
NCI

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20-alfa-dihydroprogesteron

A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA.
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dihydropteridinreduktasa

An enzyme that catalyzes the reduction of 6,7-dihydropteridine to 5,6,7,8-tetrahydropteridine in the presence of NADP+. Defects in the enzyme are a cause of PHENYLKETONURIA II. Formerly listed as EC 1.6.99.7.
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dihydropteroátsynthasa

An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
MSH

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dihydropyridiny

Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.
MSH

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dihydrostreptomycin

A semi-synthetic aminoglycoside antibiotic that is used in the treatment of TUBERCULOSIS.
MSH

A semi-synthetic aminoglycoside antibiotic with bactericidal properties. Dihydrostreptomycin sulfate inhibits protein synthesis by binding to the 30S ribosomal subunit. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tulemia.
NCI

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dihydrotachysterol

A VITAMIN D that can be regarded as a reduction product of vitamin D2.
MSH

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dihydroxyaceton

A ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent.
MSH

ketotriose compound; its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage; it is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes; in combination with naphthoquinones it acts as a sunscreening agent.
CSP

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dihydroxyacetonfosfát

An important intermediate in lipid biosynthesis and in glycolysis.
MSH

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dihydroxycholekalciferoly

Cholecalciferols substituted with two hydroxy groups in any position.
MSH

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dihydroxydihydrobenzopyreny

Benzopyrenes saturated in any two adjacent positions and substituted with two hydroxyl groups in any position. The majority of these compounds have carcinogenic or mutagenic activity.
MSH

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dihydroxytryptaminy

Tryptamine substituted with two hydroxyl groups in any position. Some are cytotoxic serotonin analogs that are preferentially taken up by serotonergic neurons and then destroy those neurons.
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dijodhydroxychin

One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.
MSH

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dijodthyroniny

These metabolites of THYROXINE are formed by the deiodination of T3 or reverse T3.
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dijodtyrosin

A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).
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dilatace

The act of dilating.
MSH

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dilatace a kyretáž

Dilatation of the cervix uteri followed by a scraping of the endometrium with a curette.
MSH

A minor operation in which the cervix is expanded enough (dilation) to permit the cervical canal and uterine lining to be scraped with a spoon-shaped instrument called a curette (curettage).
NCI

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dilatace patologická

The condition of an anatomical structure`s being dilated beyond normal dimensions.
MSH

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dilazep

Coronary vasodilator with some antiarrhythmic activity.
MSH

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diltiazem

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
MSH

substituted benzothiazepine with specific blocking activity against inward rectifying calcium channel.
CSP

A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the ion-control gating mechanisms, thereby preventing calcium levels increase by other revenues. Alternatively, it has been suggested that this agent also interferes with the release of calcium from the sarcoplasmic reticulum and inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The overall low calcium levels leads to dilatation of the main coronary and systemic arteries and decreasing myocardial contractility, decreased peripheral arterial resistance, improved oxygen delivery to the myocardial tissue, and decreased cardiac output.
NCI

a drug used to treat high blood pressure and to control chest pain (angina)
CHV

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dimenhydrinát

A drug combination that contains DIPHENHYDRAMINE and THEOPHYLLINE. It is used for treating vertigo, motion sickness, and nausea associated with pregnancy. It is not effective in the treatment of nausea associated with cancer chemotherapy.
MSH

An ethanolamine and first-generation histamine antagonist with anti-allergic activity. Dimenhydrinate competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, GI smooth muscle spasm.
NCI

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dimerkaprol

An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
MSH

A metal chelating agent that is used as an antidote in arsenic, gold, lead, mercury and other heavy metal poisoning. Metals form ligands in the body with the sulfhydryl groups of the pyruvate-oxidase enzyme system. This leads to an inhibition of the normal functioning of these enzymes that are dependent on free sulfhydryl groups for their activity. Dimercaprol reverses the enzyme inhibition by chelating the metal and regenerates free sulfhydryl groups, thereby preventing and reversing the metals toxic effects.
NCI

a kind of antidote for arsenic, mercury, gold, and lead poisoning
CHV

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kyselina dimerkaptojantarová

A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
MSH

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dimethadion

An anticonvulsant that is the active metabolite of TRIMETHADIONE.
MSH

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dimethinden

A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
MSH

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dimethisteron

A synthetic progestational hormone without significant estrogenic or androgenic properties. It was formerly used as the progestational component in oral sequential contraceptives.
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dimethoát

An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.
MSH

organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.
CSP

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dimethyladipimidát

Bifunctional cross-linking agent that links covalently free amino groups of proteins or polypeptides, including those in cell membranes. It is used as reagent or fixative in immunohistochemistry and is a proposed antisickling agent.
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dimethylsuberimidát

The methyl imidoester of suberic acid used to produce cross links in proteins. Each end of the imidoester will react with an amino group in the protein molecule to form an amidine.
MSH

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