Additional pages

hemoglobinopatie s hemoglobinem C

A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.
MSH

A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia. This disorder is caused by a specific mutation in the beta-globin HBB gene, whereby a lysine is substituted for a glutamic acid at the sixth amino acid in the protein.
NCI

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hemoglobin E

An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.
MSH

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hemoglobin H

An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in ALPHA-THALASSEMIA.
MSH

abnormal hemoglobin composed of 4 beta chains, found in alpha thalassemia, and associated with severe hemolytic anemia.
CSP

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hemoglobin J

A group of abnormal hemoglobins with similar electrophoretic characteristics. They have faster electrophoretic mobility and different amino acid substitutions in either the alpha or beta chains than normal adult hemoglobin. Some of the variants produce hematologic abnormalities, others result in no clinical disorders.
MSH

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hemoglobin M

A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha or beta chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis.
MSH

An abnormal hemoglobin assay is a device consisting of the reagents, apparatus, instrumentation, and controls necessary to isolate and identify abnormal genetically determined hemoglobin types.
SPN

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hemoglobinopatie s hemoglobinem SC

One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.
MSH

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hemoglobin srpkovitý

An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
MSH

abnormal hemoglobin caused by a point mutation in the beta chains, found in sickle cell anemia.
CSP

An abnormal hemoglobin assay is a device consisting of the reagents, apparatus, instrumentation, and controls necessary to isolate and identify abnormal genetically determined hemoglobin types.
SPN

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hemoglobinometrie

Measurement of hemoglobin concentration in blood.
MSH

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hemoglobinopatie

A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
MSH

group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
CSP

An inherited disorder characterized by structural alterations of a globin chain within the hemoglobin molecule.
NCI

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hemoglobiny

The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
MSH

oxygen carrying pigment of the erythrocytes; a complex protein composed of four heme groups and four globin polypeptide chains.
CSP

The substance inside red blood cells that binds to oxygen in the lungs and carries it to the tissues.
NCI

The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb.
NCI

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hemoglobiny abnormální

Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
MSH

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hemoglobinurie

The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.
MSH

presence of free hemoglobin in the urine.
CSP

A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.
NCI

A laboratory test result which indicates free hemoglobin in the urine.
NCI

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hemoglobinurie paroxysmální

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
MSH

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hemolymfa

The blood/lymphlike nutrient fluid of some invertebrates.
MSH

bloodlike fluid moving through the hemocoelom of invertebrates with open circulatory systems which combines the properties of blood and lymphlike interstitial fluid.
CSP

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hemolyzinové faktory

Plasmids controlling the synthesis of hemolysin by bacteria.
MSH

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hemolyziny

group of substances, usually of biological origin, that destroy blood cells; they may be antibodies or other immunologic factors, toxins, or enzymes.
CSP

Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.
MSH

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hemolýza

The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
MSH

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hemolytická plaková technika

A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
MSH

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hemolyticko-uremický syndrom

A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.
MSH

A form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
NCI

A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
NCI

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hemoperfúze

Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).
MSH

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hemoperitoneum

Accumulations of blood in the PERITONEAL CAVITY due to internal HEMORRHAGE.
MSH

Bleeding originating from the peritoneum.
NCI

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hemopexin

a blood glycoprotein found in the beta globulin fraction which binds free heme and other porphyrins.
CSP

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reaktivní hemofagocytární syndrom

Proliferation of HISTIOCYTES in response to viral, bacterial, fungal, or parasitic infections.
MSH

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hemofilie A

The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
MSH

classic hemophilia resulting from a deficiency of factor VIII; an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
CSP

An inherited deficiency of coagulation factor VIII characterized by the tendency to spontaneous or exaggerated post-traumatic hemorrhage. Inherited as an x-linked recessive disease, hemophilia A is the most common hemophilia, occurring in approximately 1 in 10,000 male births.
NCI

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hemopneumotorax

Collection of air and blood in the pleural cavity.
MSH

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HEMOPTISIA

Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.
MSH

Coughing or spitting up blood from the respiratory tract.
NCI

Coughing up blood from the respiratory tract.
NCI

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hemoragie

Bleeding or escape of blood from a vessel.
MSH

escape of blood from the vessels; bleeding.
CSP

In medicine, loss of blood from damaged blood vessels. A hemorrhage may be internal or external, and usually involves a lot of bleeding in a short time.
NCI

The flow of blood from a ruptured blood vessel.
NCI

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hemoragické poruchy

spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (vascular hemostatic disorders).
CSP

Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
MSH

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hemoragická nemoc novorozenců

self-limited hemorrhagic disorder of the first days of life, caused by a deficiency of the vitamin K-dependent blood coagulation factors II, VII, IX, and X.
CSP

Neonatal nasogastric or intracranial hemorrhage caused by vitamin K deficiency.
MSH

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virus Junin

A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. The disease is characterized by congestion, edema, generalized lymphadenopathy and hemorrhagic necrosis and is sometimes fatal.
MSH

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