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Herpesviridae – infekce

infection by a member of the Herpesviridae family, a family of enveloped, linear, double-stranded DNA viruses; occurs in a wide variety of animals.
CSP

Virus diseases caused by the HERPESVIRIDAE.
MSH

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herpesvirus 2 saimiriine

produces malignant lymphomata in marmosets and owl monkeys with lymphocytosis and reticular cell invasion of the viscera.
CSP

A virus in the family herpesviridae and the type species of rhadinovirus. It is an enveloped virus with a genome consisting of a single segment of double-stranded DNA that is approximately 112kb in length. It normally infects squirrel monkeys, where it creates a persistent infection.
NCI

The type species of RHADINOVIRUS, in the subfamily GAMMAHERPESVIRINAE, isolated from squirrel monkeys. It produces malignant lymphomas (LYMPHOMA, MALIGNANT) in inoculated marmosets or owl monkeys.
MSH

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herpesvirus opic B

A species of SIMPLEXVIRUS that causes vesicular lesions of the mouth in monkeys. When the virus is transmitted to man it causes an acute encephalitis or encephalomyelitis, which is nearly always fatal.
MSH

virus which naturally infects Asiatic monkeys; causes vesicular lesions of the tongue and lips, acute encephalitis, and almost always death in humans.
CSP

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herpesvirus 6 lidský

The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren`s syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.
MSH

species of Roseolovirus isolated from patients with AIDS and other lymphoproliferative disorders; it appears to alter NK cell activity; HHV-6 is the cause of exanthema subitum and has been implicated in encephalitis.
CSP

A human herpesvirus that has been found in certain lymphoproliferative disorders, replicates in a number of different types of leukocytes, and is associated with the childhood disease roseola (exanthema subitum). (On-line Medical Dictionary)
NCI

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hesperidin

A flavanone glycoside found in CITRUS fruit peels.
MSH

A flavonoid comprised of the flavanone hesperetin and the disaccharide rutinose.
NCI

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heterochromatin

The portion of chromosome material that remains condensed and is transcriptionally inactive during INTERPHASE.
MSH

regions of the genome that are permanently in a highly condensed condition and are not genetically expressed.
CSP

A compact and highly condensed form of chromatin. [GOC:elh]
GO

A tightly packed area of chromatin that may function to protect chromosome integrity and regulate gene expression.
NCI

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heterocyklické sloučeniny

Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh`s Chemical Dictionary, 5th ed)
MSH

ring compounds having atoms other than carbon in their nuclei.
CSP

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heterocyklické sloučeniny monocyklické

A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
MSH

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heterocyklické sloučeniny bicyklické

A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
MSH

A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic. (MeSH)
NCI

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heterocyklické sloučeniny tricyklické

A class of organic compounds containing three ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic
MSH

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heterocyklické sloučeniny tetra- a více cyklické

A class of organic compounds containing four or more ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
MSH

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heterocyklické sloučeniny – jádro s vnitřním můstkem

A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
MSH

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heterocyklické oxidy

Oxides of a ring compound having atoms other than carbon in its ring.
MSH

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heterogenita

Made up of elements or ingredients that are not alike.
NCI

The quality or state of consisting of elements that are not of the same kind or nature.
NCI

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Heterophyidae

A family of intestinal flukes of the class Trematoda which occurs in animals and man. Some of the genera are Heterophyes, Metagonimus, Cryptocotyle, Stellantchasmus, and Euryhelmis.
MSH

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heterosexualita

The sexual attraction or relationship between members of the opposite SEX.
MSH

A sexual attraction to members of the opposite sex. (WordNet)
NCI

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heterozygot

An individual having different alleles at one or more loci regarding a specific character.
MSH

having different alleles at one or more loci in homologous chromosome segments.
CSP

Having two different allelic forms of a gene, one inherited from each parent, on each of the two homologous chromosomes.
NCI

Occurs when the two alleles at a particular gene locus are different. A heterozygous genotype may include one normal allele and one mutation, or two different mutations. The latter is called a compound heterozygote.
NCI

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heterozygot – detekce

Identification of genetic carriers for a given trait.
MSH

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hexachlorbenzen

An agricultural fungicide and seed treatment agent.
MSH

agricultural fungicide and seed treatment agent.
CSP

A stable, white, crystalline chlorinated hydrocarbon that emits very toxic fumes of carbon monoxide, carbon dioxide, hydrochloric acid and other chlorinated compounds when heated to decomposition. Hexachlorobenzene was used as a fungicide and was also used as a chemical intermediate in the manufacture of dyes, synthesis of organic chemicals, rubber and in wood preservation. Prolonged oral exposure to this substance results in a liver disease with associated skin lesions. Hexachlorobenzene is reasonably anticipated to be a human carcinogen based on association between thyroid, liver and kidney cancer and oral exposure in animals. (NCI05)
NCI

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hexachlorofen

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
MSH

A chlorinated bisphenol antiseptic agent with bacteriostatic activity. Hexachlorophene is used topically in soaps, creams and dermatological preparations and is active against gram-positive organisms, but much less effective against gram-negative organisms. (NCI05)
NCI

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hexadimethrin

A synthetic polymer which agglutinates red blood cells. It is used as a heparin antagonist.
MSH

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hexamethoniové sloučeniny

Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.
MSH

compounds containing the hexamethylenebis (trimethylammonium) cation; members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.
CSP

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hexamethylmelamin

A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
MSH

An anticancer drug that belongs to the family of drugs called alkylating agents.
NCI

A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39475&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39475&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C544″ NCI Thesaurus)
PDQ

A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)
NCI

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hexany

Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.
MSH

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hexanony

6-carbon straight-chain or branched ketones.
MSH

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hexestrol

A synthetic estrogen that has been used as a hormonal antineoplastic agent.
MSH

A synthetic hydrogenated derivative of diethylstilbestrol (DES). Hexestrol exhibits strong affinity for estrogen receptors that are overexpressed in some types of cancers. When conjugated with a neoplastic drug, hexestrol may selectively concentrate the cytotoxic agent in estrogen receptor-rich tumors. This agent may also be mutagenic. (NCI04)
NCI

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hexetidin

A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
MSH

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hexobarbital

A barbiturate that is effective as a hypnotic and sedative.
MSH

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hexobendin

A potent vasoactive agent that dilates cerebral and coronary arteries, but slightly constricts femoral arteries, without any effects on heart rate, blood pressure or cardiac output.
MSH

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hexokinasa

An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
MSH

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