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hydroxylace

Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
MSH

adding a hydroxyl group to a compound in a new position.
CSP

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hydroxylysin

A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.
MSH

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benzoáty hydroxyrtuťnaté

Hydroxylated benzoic acid derivatives that contain mercury. Some of these are used as sulfhydryl reagents in biochemical studies.
MSH

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hydroxymethylglutaryl-CoA-reduktasy

Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
MSH

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hydroxymethylglutaryl-CoA-synthasa

An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.
MSH

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hydroxyfenylazouracil

Inhibitor of DNA replication in gram-positive bacteria.
MSH

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hydroxyprogesterony

Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.
MSH

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hydroxyprolin

A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
MSH

C5H9NO3; amino acid derived from proline, found in collagen and gelatin.
CSP

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hydroxyprostaglandindehydrogenasy

Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.
MSH

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hydroxychinoliny

The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.
MSH

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hydroxysteroiddehydrogenasy

Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.
MSH

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hydroxysteroidy

steroids in which one or more hydroxy groups have been substituted for hydrogen atoms either within the ring skeleton or on any of the side chains.
CSP

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hydroxytestosterony

17 beta-Hydroxy-4-androsten-3-ones. Testosterone derivatives formed by the substitution of one or more hydroxyl groups in any position.
MSH

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hydroxytryptofol

5-Hydroxy-indole-3-ethanol.
MSH

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hydroxymočovina

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
MSH

ribonucleotide reductase inhibitor which thereby lowers intracellular dNTP pools and slows DNA replication and repair; used as antineoplastic, cell devision inhibitor, and possible chemotherapy for sickle cell anemia.
CSP

An anticancer drug that belongs to the family of drugs called antimetabolites.
NCI

A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40685&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40685&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C560″ NCI Thesaurus)
PDQ

A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)
NCI

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hydroxyzin

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
MSH

a kind of antihistamine and mild anti-anxiety drug
CHV

A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine`s antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
NCI

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hygiena

The science dealing with the establishment and maintenance of health in the individual and the group. It includes the conditions and practices conducive to health. (Webster, 3d ed)
MSH

The science of health, and the practice of cleanliness that promotes good health and well-being.
NCI

The science concerned with the prevention of illness and maintenance of health.
NCI

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hygromycin B

Aminoglycoside produced by Streptomyces hygroscopicus. It is used as an anthelmintic against swine infections by large roundworms, nodular worms, and whipworms.
MSH

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Hylobates

A genus of the family HYLOBATIDAE consisting of six species. The members of this genus inhabit rain forests in southeast Asia. They are arboreal and differ from other anthropoids in the great length of their arms and very slender bodies and limbs. Their major means of locomotion is by swinging from branch to branch by their arms. Hylobates means dweller in the trees. Some authors refer to Symphalangus and Nomascus as Hylobates. The six genera include: H. concolor (crested or black gibbon), H. hoolock (Hoolock gibbon), H. klossii (Kloss`s gibbon; dwarf siamang), H. lar (common gibbon), H. pileatus (pileated gibbon), and H. syndactylus (siamang). H. lar is also known as H. agilis (lar gibbon), H. moloch (agile gibbon), and H. muelleri (silvery gibbon).
MSH

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hymekromon

A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.
MSH

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hymenolepiáza

Infection with tapeworms of the genus Hymenolepis.
MSH

A parasitic infection caused by tapeworms. Most infected individuals do not have symptoms. When symptoms appear, they include diarrhea, abdominal pain, restlessness, and irritability.
NCI

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Hymenolepis

A genus of small tapeworms of birds and mammals.
MSH

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Hymenoptera

order of insects, including bees, wasps, and ants, characterized by high development of social or colonial behavior and usually by locked pairs of membranous wings.
CSP

An extensive order of highly specialized insects including bees, wasps, and ants.
MSH

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os hyoideum

A mobile U-shaped bone that lies in the anterior part of the neck at the level of the third CERVICAL VERTEBRAE. The hyoid bone is suspended from the processes of the TEMPORAL BONES by ligaments, and is firmly bound to the THYROID CARTILAGE by muscles.
MSH

A U-shaped bone supporting the tongue. This bone is located at the base of the tongue and is suspended from the tips of the styloid processes of the temporal bones by the stylohyoid ligaments. (NCI)
NCI

A U-shaped bone supporting the tongue. This bone is located at the base of the tongue and is suspended from the tips of the styloid processes of the temporal bones by the stylohyoid ligaments.
NCI

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hyperaldosteronismus

A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
MSH

abnormality of electrolyte function caused by excessive secretion of aldosterone by the adrenal cortex.
CSP

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hyperalgezie

An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
MSH

excessive sensitivity to painful stimuli.
CSP

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hyperbarická oxygenace

The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.
MSH

therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures; considered effective treatment for air and gas embolisims, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc.
CSP

The use of a pressurized chamber for the delivery of oxygen in higher concentrations for therapeutic benefit. Useful in the treatment of severe burns, peripheral vascular disease, carbon monoxide poisoning and decompression illness. (from On-line Medical Dictionary)
NCI

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hyperbilirubinémie

A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.
MSH

pathologic process consisting of an abnormal increase in the amount of bilirubin in the circulating blood, which may result in jaundice.
CSP

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hyperbilirubinémie dědičná

Inborn errors of bilirubin metabolism resulting in excessive amounts of bilirubin in the circulating blood, either because of increased bilirubin production or because of delayed clearance of bilirubin from the blood.
MSH

An inherited disorder affecting the metabolism of bilirubin. It results in increased levels of bilirubin in the blood. Representative examples of this condition include Gilbert syndrome and Crigler-Najjar syndrome.
NCI

inborn errors of bilirubin metabolism resulting in excessive amounts of bilirubin in the circulating blood, either because of increased bilirubin production or because of delayed clearance of bilirubin from the blood.
CSP

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hyperkalcémie

Abnormally high level of calcium in the blood.
MSH

abnormally high level of calcium in the blood; manifestations include fatigability, muscle weakness, depression, anorexia, nausea, and constipation.
CSP

Higher than normal levels of calcium in the blood. Some types of cancer increase the risk of hypercalcemia.
NCI

A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium in blood.
NCI

high level of calcium in the blood
CHV

Abnormally high concentration of calcium in the peripheral blood.
NCI

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