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Recombinant Interferon-gamma

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
NCI

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interferonové induktory

Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.
MSH

agents that promote the production and release of interferons; they include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C; viruses, bacteria, and protozoa have been also known to induce interferons.
CSP

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interferon typ I

Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
MSH

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interferon gama

activates NK cells, cytotoxic T cells, endothelial cells, and macrophages; stimulates LAK activity; costimulates B cell proliferation; inhibits T cell proliferation; implicated in aberrant expression of MHC II antigens leading to autoimmune disease.
CSP

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
MSH

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40469&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40469&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C583″ NCI Thesaurus)
PDQ

The gamma or immune IFNs are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized. They are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)
NCI

Interferon gamma (IFNg) is produced by activated T cells and is an important immunoregulatory molecule, particularly in allergic diseases.
NCI

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interferony

Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
MSH

a group of proteins elaborated by infected host cells that protect noninfected cells from viral infection.
CSP

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interinstitucionální vztahy

The interactions between representatives of institutions, agencies, or organizations.
MSH

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vnitřní vybavení a bytové zařízení

The planning of the furnishings and decorations of an architectural interior.
MSH

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interleukin-1beta

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
MSH

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes and activated macrophages, endogenous mature IL-1 is generated through proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent promotes angiogenesis, fibroblast proliferation, and neutrophil chemotaxis; it also regulates the functions of lymphocytes and epithelial cells and is involved in the `acute phase response` to infection. Check for “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40793&idtype=1″ active clinical trials or “http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40793&idtype=1&closed=1″ closed clinical trials using this agent. (“http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C585″ NCI Thesaurus)
PDQ

Interleukin-1 (endogenous pyrogen), produced primarily by monocytes, is an important pro-inflammatory cytokine that mediates the acute phase host response. The biologic activities of IL1 are properties of a protein derived from a larger precursor. Inflammation causes induction of COX2, leading to release of prostanoids, which sensitize peripheral nociceptor terminals and produce local pain hypersensitivity. Inflammation also generates sensitivity in neighboring tissue, muscle and joint pain, fever, lethargy, and anorexia. COX2 induction in regions of the CNS is mediated by IL1B. Interleukin-1-beta also stimulates bone resorption. IL1RN is a competitive inhibitor of IL1B. Mature IL1-beta levels are a sensitive and specific indicator of caspase-1 activation. (from OMIM 147720 and NCI)
NCI

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interleukin-1

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
MSH

macrophage produced interleukin that induces the production of interleukin 2 by T cells that have been stimulated by antigen or mitogen; at least two types, alpha and beta, exist; interleukin 1 or a similar protein is also produced by epithelial cells and stimulates fibroblast proliferation and release of proteolytic enzymes and prostaglandins in inflammatory processes.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-1 is made mainly by one type of white blood cell, the macrophage, and helps another type of white blood cell, the lymphocyte, fight infections. It also helps leukocytes pass through blood vessel walls to sites of infection and causes fever by affecting areas of the brain that control body temperature. There are two forms of IL-1, alpha and beta, which act the same. IL-1 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. IL-1 is a type of cytokine.
NCI

Human interleukin-1 protein (271 aa, 31 kD precursor) is encoded by the human interleukin-1 (IL1) gene. This soluble protein is produced primarily by monocytes and macrophages. It activates and potentiates T-lymphocyte responses to mitogens or antigens. This protein is also capable of replacing macrophage requirements for T-cell activation
NCI

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interleukin-2

A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
MSH

interleukin 2 is produced by T cells in response to antigenic or mitogenic stimulation and the signal carried by interleukin 1; it stimulates the proliferation of T cells bearing specific receptors for interleukin 2, expressed by antigenically stimulated T cells; it also seems to induce production of interferon gamma, and is used as an anticancer agent in a wide variety of solid malignant tumors.
CSP

Encoded by human IL2 Gene, Interleukin-2 is a secreted cytokine important for proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2 expression in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling expression of a single gene. Targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role in the immune response to antigenic stimuli. (From LocusLink)
NCI

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interleukin-3

A multilineage cell growth factor secreted by LYMPHOCYTES; EPITHELIAL CELLS; and ASTROCYTES which stimulates clonal proliferation and differentiation of various types of blood and tissue cells.
MSH

lymphokine produced by antigen or mitogen activated T lymphocytes which stimulates proliferation of hematopoietic as well as lymphoid stem cells; a colony stimulating factor for bone marrow progenitor cells; supports growth and differentiation of early hematopoieteic and lymphoid stem cells as well as that of more mature hematopoietic cells, including granulocytes, macrophages and mast cells.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-3 is made mainly by a type of T lymphocyte. It increases the number of blood cells made by the bone marrow. IL-3 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. IL-3 is a type of cytokine.
NCI

A group of proteins that causes blood cells to grow and mature.
NCI

Human interleukin-3 (152 aa, 17 kDa precursor) is encoded by the human interleukin-3 (IL3) gene. This protein is a potent growth-promoting cytokine that enhances the ability of the immune system to fight tumor cells. IL-3 supports proliferation of many hematopoietic cell types. It is involved in cell growth, differentiation and apoptosis in addition to possessing neurotrophic activity. Abnormalities in this protein may be associated with neurologic disorders.
NCI

Endogenous growth factors which promote the development of blood cells.
NCI

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interleukin-4

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
MSH

lymphokine produced by antigen or mitogen activated T lymphocytes that enhances the ability of B lymphocytes to present antigen, primes B lymphocytes to proliferate in response to anti-Ig and lipopolysaccharide, and regulates the production of IgG and IgE by B lymphocytes; it also acts as a growth factor for T lymphocytes and as a maturation factor for mast cells.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-4 is made by a type of T lymphocyte. It causes B lymphocytes to increase and to make antibodies and also increases the production of T lymphocytes. Interleukin-4 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-4 is a type of cytokine.
NCI

Human interleukin-4 protein (153 aa, 17.5 kDa precursor) is encoded by the human interleukin-4 (IL4) gene. Two isoforms of this protein are expressed by activated T cells. This protein is a pleiotropic soluble cytokine that is a ligand for the interleukin 4 receptor. This receptor-ligand interaction induces expression of MHC II and Fc receptors on B-cells, causing proliferation and differentiation of these cells.
NCI

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interleukin-5

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
MSH

lymphokine produced by antigen or mitogen activated T lymphocytes that acts as a differentiation factor for B lymphocytes and eosinophils and increases the production of IgA by B lymphocytes.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-5 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and increases the number of eosinophils. IL-5 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. It is a type of cytokine.
NCI

Human interleukin-5 protein (134 aa, 15 kDa precursor) is encoded by the human interleukin-5 (IL5) gene. This cytokine acts as a growth and differentiation factor for eosinophils and induces terminal differentiation of B-cells which become Ig-secreting cells. It is thought to play a pivotal role in the pathogenesis of asthma. Elevated levels of this protein have been detected in both asthma and hypereosinophilic syndromes.
NCI

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interleukin-6

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
MSH

cytokine produced by antigen or mitogen activated T lymphocytes, fibroblasts and macrophages that serves as a differentiation factor for lymphocytes and stimulates immunoglobulin production by B lymphocytes; it also innitiates the cell cycle in primitive hematopoietic cells in vitro.
CSP

Interleukin-6 (IL-6), a glycoprotein produced by activated T-cells and a variety of other cells, induces the production of IgM by B-cells and can be used to replace feeder cells for the growth and maintenance of B-cell hybridomas in vitro.
NCI

Produced by T-cells, monocytes, fibroblasts, and many other cells, Interleukin 6 stimulates the growth of hybridomas and plasmacytomas, as well as the growth and differentiation of B-cells. Il6 increases synthesis and secretion of immunoglobulins by B-lymphocytes. The biologic significance of IL6 lies in the fact that it is induced under conditions in which IFN-beta 1 is not induced, as in metabolically stressed cells. Its induction by IL1 and TNF suggests that it may play a role as an autocrine mediator of these cytokines in inflammation and acute phase responses, as well as regulate cell proliferation. In addition to its antiviral activity, IL6 elicits an acute phase response in liver cells and is identical to hepatocyte stimulatory factor. (from OMIM 147620 and NCI)
NCI

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interleukin-7

A cytokine produced by bone marrow stromal cells that promotes the growth of B-LYMPHOCYTE precursors and is co-mitogenic with INTERLEUKIN-2 for mature T-LYMPHOCYTE activation.
MSH

produced by epithelial and mesangial stromal cells; serves as a differentiation factor for B cell early development; also supports growth of some thymocytes and T lymphocytes.
CSP

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-7 is made by cells that cover and support organs, glands, and other structures in the body. It causes the growth of T lymphocytes and B lymphocytes. IL-7 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. IL-7 is a type of cytokine.
NCI

Encoded by human IL7 Gene, Interleukin-7 is an important cytokine for B and T cell development. This cytokine and HGF form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is a cofactor for V(D)J rearrangement of T cell receptor beta (TCRB) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may be a regulatory factor for intestinal mucosal lymphocytes. Studies in mice suggest that IL7 plays an essential role in lymphoid cell survival. (From LocusLink)
NCI

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interleukiny

Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.
MSH

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. ILs regulate immune responses. ILs made in the laboratory are used as biological response modifiers to boost the immune system in cancer therapy. An interleukin is a type of cytokine.
NCI

Interleukin is the generic name for a group of well-characterized cytokines that are produced by leukocytes and other cell types. They have a broad spectrum of functional activities that regulate the activities and capabilities of a wide variety of cell types. They are particularly important as members of the cytokine networks that regulate inflammatory and immune responses.
NCI

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pečovatelské domovy se zprostředkovatelskou péčí

Institutions which provide health-related care and services to individuals who do not require the degree of care which hospitals or skilled nursing facilities provide, but because of their physical or mental condition require care and services above the level of room and board.
MSH

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proteiny intermediálních filament

Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.
MSH

Protein that primarily constitutes an intermediate filament which provide strength or anchorage of other cellular structures. Examples: keratin, vimentin, desmin.
UWDA

Encoded by Intermediate Filament Genes, diverse Intermediate Filament Proteins (including keratin filaments, neurofilaments, desmin, and vimentin) form polymeric structural cytoplasmic filaments, intermediate in diameter (8-10 nanometer) between actin microfilaments and microtubules, that comprise part of the cytoskeleton of most eukaryotic cells. (NCI)
NCI

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intermediální filamenta

Cytoplasmic filaments intermediate in diameter (about 10 nanometers) between the microfilaments and the microtubules. They may be composed of any of a number of different proteins and form a ring around the cell nucleus.
MSH

cytoplasmic filament intermediate in diameter (about 10 nanometers) between the microfilaments and the microtubules; may be composed of any of a number of different proteins and form a ring around the cell nucleus.
CSP

A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732 “Oxford Dictionary of Biochemistry and Molecular Biology”]
GO

A class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 8-10 nm in thickness and comprise part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are intermediate in thickness between actin filaments and microtubules.
NCI

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intermitentní klaudikace

A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
MSH

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intermitentní explozivní porucha

A disorder characterized by recurrent episodes of serious assaultive acts or destruction of property due to a failure to resist aggressive impulses; the degree of aggression during these episodes is grossly out of proportion to any psychosocial provocation. The aggressive episodes are not etiologically linked to another mental disorder, a general medical condition, or substance use.
NCI

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dýchání s přerušovaným přetlakem

Application of positive pressure to the inspiratory phase of spontaneous respiration.
MSH

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ventilace umělá s přerušovaným přetlakem

Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.
MSH

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arteria thoracica interna-arteria coronaria – anastomóza

Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
MSH

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vnitřní lékařství

A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
MSH

A medical specialty concerned with the diagnosis of diseases of the internal organs and non-surgical treatments.
NCI

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interní-externí kontrola

Personality construct referring to an individual`s perception of the locus of events as determined internally by his or her own behavior versus fate, luck, or external forces. (ERIC Thesaurus, 1996).
MSH

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mezinárodní agentury

International organizations which provide health-related or other cooperative services.
MSH

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mezinárodní spolupráce

The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
MSH

interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
CSP

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Mezinárodní rada sester

An international professional organization composed of one association per country for the purpose of improving and developing nursing`s contribution to the promotion of health and care of the sick.
MSH

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mezinárodní vzdělávací výměna

The exchange of students or professional personnel between countries done under the auspices of an organization for the purpose of further education.
MSH

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