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jodamid

An ionic monomeric contrast medium. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
MSH

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jodičnany

Inorganic salts of iodic acid (HIO3).
MSH

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jodidperoxidasa

A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.
MSH

Human thyroid peroxidase protein (933 aa, ~103 kDa isoform) is encoded by the human thyroid peroxidase (TPO) gene. This protein is the primary enzyme involved in thyroid hormone synthesis.
NCI

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jodidy

Inorganic binary compounds of iodine or the I- ion.
MSH

Iodine ion requiring removal of one electron to return to its elemental state.
NCI

A salt or ester of mineral iodine. Iodide salts are mild reducing agents and many react with oxygen to give iodine.
NCI

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jod

A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
MSH

nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90; it is a nutritionally essential element and is especially important in thyroid hormone synthesis; in solution, it has anti-infective properties and is used topically.
CSP

An element that is necessary for the body to make thyroid hormone. It is found in shellfish and iodized salt.
NCI

An element with atomic symbol I, atomic number 53, and atomic weight of 126.90.
NCI

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jod – isotopy

Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.
MSH

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jod – radioisotopy

Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
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jodipamid

A water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
MSH

A tri-iodinated benzoate derivative and ionic dimeric contrast agent used in diagnostic imaging. When administered in vivo, iodipamide is removed from the liver and secreted into the biliary tract. Like other organic iodine compounds, this agent blocks x-rays and appears opaque on x-ray film; thereby it enhances the visibility of the bile ducts and gallbladder during cholangiography and cholecystography procedures.
NCI

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jodovaný olej

A preparation of oil that contains covalently bound IODINE. It is commonly used as a RADIOCONTRAST AGENT and as a suspension medium for CHEMOTHERAPEUTIC AGENTS.
MSH

A form of poppy seed oil that contains iodine. Ethiodized oil is given by injection and builds up in the blood and lymph vessels in tumors. It is used for imaging (taking pictures) of the salivary glands and the lymph system. It is also being studied in the imaging of other organs such as the liver, lung, stomach, and thyroid. It is a type of diagnostic imaging agent.
NCI

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jodacetamid

An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
MSH

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jodacetáty

Iodinated derivatives of acetic acid. Iodoacetates are commonly used as alkylating sulfhydryl reagents and enzyme inhibitors in biochemical research.
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jodbenzoany

Benzoic acid esters or salts substituted with one or more iodine atoms.
MSH

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jodchlorhydroxychin

A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
MSH

An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors.
NCI

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kyselina jodohipurová

An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.
MSH

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jodofory

Complexes of iodine and non-ionic SURFACE-ACTIVE AGENTS acting as carrier and solubilizing agent for the iodine in water. Iodophors usually enhance bactericidal activity of iodine, reduce vapor pressure and odor, minimize staining, and allow wide dilution with water. (From Merck Index, 11th ed)
MSH

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jodpyracetát

An ionic monomeric contrast medium that was formerly used for a variety of diagnostic procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
MSH

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jodpyridony

Iodinated pyridine derivatives that are often used as contrast media.
MSH

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monojodtyrosin

A product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.
MSH

product from the iodination of tyrosine; in the biosynthesis of thyroid hormones, tyrosine is first iodized to monoiodotyrosine.
CSP

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kyselina joglykamová

A radiopaque medium. It is a mixture of its meglumine and sodium salts and is used to visualize the biliary tract.
MSH

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johexol

An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
MSH

An X-ray contrast medium containing iohexol in various concentrations, from 140 to 350 milligrams of iodine per milliliter.
NCI

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iontové kanály – gating

The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
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iontové kanály

Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.
MSH

molecule-sized pores in biomembranes that permit the passage of hydrophilic solutes such as inorganic ions, and the proteins that form such pores and control their permeability.
CSP

A transmembrane pore that presents a hydrophilic channel for ions to cross a lipid bilayer down their electrochemical gradients. Some degree of ion specificity is usually observed and typically a million ions per second may flow. Channels may be permanently open, like the potassium leak channel or they may be voltage gated, like the sodium channel or ligand gated like the acetylcholine receptor. (On-line Medical Dictionary)
NCI

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ionty – výměna

Reversible chemical reaction between a solid, often one of the ION EXCHANGE RESINS, and a fluid whereby ions may be exchanged from one substance to another. This technique is used in water purification, in research, and in industry.
MSH

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iontoměniče

High molecular weight, insoluble polymers which contain functional groups that are capable of undergoing exchange reactions (ION EXCHANGE) with either cations or anions.
MSH

A chromatographic separation material for clinical use is a device accessory (e.g., ion exchange absorbents, ion exchagne resins, and ion papers) intended for use in ion exchange chromatography, a procedure in which a compound is separated from a solution.
SPN

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ionomycin

A divalent calcium ionophore that is widely used as a tool to investigate the role of intracellular calcium in cellular processes.
MSH

a polyether ionophore.
CSP

A polyether antibiotic isolated from Streptomyces conglobatus sp. nov. Trejo with antineoplastic activity. Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis. In addition, this agent is used to investigate the role of intracellular calcium in cellular processes. (NCI)
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ionofory

Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes.
MSH

molecule that allows ions to cross lipid bilayers; there are two classes: carriers and channels; carriers, like valinomycin, form cage like structures around specific ions, diffusing freely through the hydrophobic regions of the bilayer; channels, like gramicidin, form continuous aqueous pores through the bilayer, allowing ions to diffuse through.
CSP

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ionty

An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
MSH

atom or radical having an electrical charge owing to the loss or gain of one or more electrons; substances that form ions are called electrolytes.
CSP

a charged particle
CHV

An atom or a molecule that has a positive or negative electrical charge. Examples are sodium, potassium, calcium, chloride, and phosphate. These ions help move nutrients into cells, help move waste out of cells, and help nerves, muscles, the heart, and the brain work the way they should.
NCI

An atom or molecule having a positive or negative charge owing to the loss or gain of one or more electrons.
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iontoforéza

Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.
MSH

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jopamidol

A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.
MSH

An organic iodine compound and used as a non-ionic water soluble radiographic contrast medium. Iopamidol blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iopamidol is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iopamidol. (NCI05)
NCI

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kyselina jopanová

Radiopaque medium used as diagnostic aid.
MSH

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